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Snx10 sorting nexin 10 [ Mus musculus (house mouse) ]

Gene ID: 71982, updated on 21-Apr-2024

Summary

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Official Symbol
Snx10provided by MGI
Official Full Name
sorting nexin 10provided by MGI
Primary source
MGI:MGI:1919232
See related
Ensembl:ENSMUSG00000038301 AllianceGenome:MGI:1919232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410004M09Rik
Summary
Predicted to enable 1-phosphatidylinositol binding activity and ATPase binding activity. Involved in osteoclast differentiation. Acts upstream of or within several processes, including bone mineralization involved in bone maturation; bone resorption; and cellular response to leukemia inhibitory factor. Located in several cellular components, including apical cytoplasm; endoplasmic reticulum; and secretory granule. Is expressed in forelimb and humerus cartilage condensation. Used to study autosomal recessive osteopetrosis 8. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 8. Orthologous to human SNX10 (sorting nexin 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 11.5), cortex adult (RPKM 10.9) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B3; 6 24.95 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (51500882..51567659)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (51523900..51590679)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15871 Neighboring gene STARR-seq mESC enhancer starr_15873 Neighboring gene nuclear factor, erythroid derived 2, like 3 Neighboring gene heterogeneous nuclear ribonucleoprotein A2/B1 Neighboring gene STARR-seq mESC enhancer starr_15875 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:51459345-51459528 Neighboring gene STARR-seq mESC enhancer starr_15881 Neighboring gene chromobox 3 Neighboring gene predicted gene, 52883 Neighboring gene predicted gene, 53331 Neighboring gene STARR-seq mESC enhancer starr_15887 Neighboring gene STARR-seq mESC enhancer starr_15888 Neighboring gene STARR-positive B cell enhancer mm9_chr6:51663532-51663833 Neighboring gene predicted gene, 38811 Neighboring gene STARR-seq mESC enhancer starr_15891 Neighboring gene VISTA enhancer mm412 Neighboring gene src family associated phosphoprotein 2 Neighboring gene STARR-seq mESC enhancer starr_15896 Neighboring gene STARR-seq mESC enhancer starr_15897

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation. Bao W, et al. Pharmacol Res, 2021 Jul. PMID 34010669
  2. An SNX10-dependent mechanism downregulates fusion between mature osteoclasts. Barnea-Zohar M, et al. J Cell Sci, 2021 May 1. PMID 33975343, Free PMC Article
  3. Massive osteopetrosis caused by non-functional osteoclasts in R51Q SNX10 mutant mice. Stein M, et al. Bone, 2020 Jul. PMID 32278070
  4. SNX10 mediates alcohol-induced liver injury and steatosis by regulating the activation of chaperone-mediated autophagy. You Y, et al. J Hepatol, 2018 Jul. PMID 29452206
  5. SNX10 promotes phagosome maturation in macrophages and protects mice against Listeria monocytogenes infection. Lou J, et al. Oncotarget, 2017 Aug 15. PMID 28903313, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SNX10 promoted liver IR injury by facilitating macrophage M1 polarization via NLRP3 inflammasome activation.
    Title: SNX10 promoted liver IR injury by facilitating macrophage M1 polarization via NLRP3 inflammasome activation.
  2. Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells.
    Title: Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells.
  3. Long noncoding RNA H19 synergizes with STAT1 to regulate SNX10 in rheumatoid arthritis.
    Title: Long noncoding RNA H19 synergizes with STAT1 to regulate SNX10 in rheumatoid arthritis.
  4. Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation.
    Title: Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation.
  5. An SNX10-dependent mechanism downregulates fusion between mature osteoclasts.
    Title: An SNX10-dependent mechanism downregulates fusion between mature osteoclasts.
  6. Snx10 and PIKfyve are required for lysosome formation in osteoclasts.
    Title: Snx10 and PIKfyve are required for lysosome formation in osteoclasts.
  7. Massive osteopetrosis caused by non-functional osteoclasts in R51Q SNX10 mutant mice.
    Title: Massive osteopetrosis caused by non-functional osteoclasts in R51Q SNX10 mutant mice.
  8. SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC.
    Title: SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC.
  9. FKBP12: A partner of Snx10 required for vesicular trafficking in osteoclasts.
    Title: FKBP12: A partner of Snx10 required for vesicular trafficking in osteoclasts.
  10. this work revealed that SNX10 controls mTOR activation through regulating chaperone-mediated autophagy-dependent amino-acid metabolism.
    Title: Sorting nexin 10 controls mTOR activation through regulating amino-acid metabolism in colorectal cancer.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bone mineralization involved in bone maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within bone remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within bone resorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular homeostasis IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gastric acid secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to cilium ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ruffle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tooth eruption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extrinsic component of endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in secretory granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sorting nexin-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127348.1 → NP_001120820.1  sorting nexin-10 isoform a

    See identical proteins and their annotated locations for NP_001120820.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AK028163, AK150878, AK151320, AK166121
    Consensus CDS
    CCDS20136.1
    UniProtKB/Swiss-Prot
    Q8C1E0, Q9CWT3
    UniProtKB/TrEMBL
    Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
    Related
    ENSMUSP00000136974.2, ENSMUST00000179365.8
    Conserved Domains (1) summary
    cd06898
    Location:12 → 109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

  2. NM_001127349.1 → NP_001120821.1  sorting nexin-10 isoform a

    See identical proteins and their annotated locations for NP_001120821.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AK150878, AK151320
    Consensus CDS
    CCDS20136.1
    UniProtKB/Swiss-Prot
    Q8C1E0, Q9CWT3
    UniProtKB/TrEMBL
    Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
    Related
    ENSMUSP00000044165.9, ENSMUST00000049152.15
    Conserved Domains (1) summary
    cd06898
    Location:12 → 109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

  3. NM_001361576.1 → NP_001348505.1  sorting nexin-10 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longer isoform (a). Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AC153877
    Consensus CDS
    CCDS20136.1
    UniProtKB/Swiss-Prot
    Q8C1E0, Q9CWT3
    UniProtKB/TrEMBL
    Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
    Related
    ENSMUSP00000117914.2, ENSMUST00000137212.8
    Conserved Domains (1) summary
    cd06898
    Location:12 → 109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

  4. NM_001361577.1 → NP_001348506.1  sorting nexin-10 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AC153877
    Consensus CDS
    CCDS20136.1
    UniProtKB/Swiss-Prot
    Q8C1E0, Q9CWT3
    UniProtKB/TrEMBL
    Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
    Conserved Domains (1) summary
    cd06898
    Location:12 → 109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

  5. NM_001361578.1 → NP_001348507.1  sorting nexin-10 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AC153877
    Consensus CDS
    CCDS20136.1
    UniProtKB/Swiss-Prot
    Q8C1E0, Q9CWT3
    UniProtKB/TrEMBL
    Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
    Conserved Domains (1) summary
    cd06898
    Location:12 → 109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

  6. NM_001361579.1 → NP_001348508.1  sorting nexin-10 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AC153877
    Consensus CDS
    CCDS20136.1
    UniProtKB/Swiss-Prot
    Q8C1E0, Q9CWT3
    UniProtKB/TrEMBL
    Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
    Conserved Domains (1) summary
    cd06898
    Location:12 → 109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

  7. NM_001361580.1 → NP_001348509.1  sorting nexin-10 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AC153877
    Consensus CDS
    CCDS20136.1
    UniProtKB/Swiss-Prot
    Q8C1E0, Q9CWT3
    UniProtKB/TrEMBL
    Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
    Conserved Domains (1) summary
    cd06898
    Location:12 → 109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

  8. NM_001361581.1 → NP_001348510.1  sorting nexin-10 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AC153877
    Consensus CDS
    CCDS20136.1
    UniProtKB/Swiss-Prot
    Q8C1E0, Q9CWT3
    UniProtKB/TrEMBL
    Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
    Conserved Domains (1) summary
    cd06898
    Location:12 → 109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

  9. NM_001361582.1 → NP_001348511.1  sorting nexin-10 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC153877
    UniProtKB/TrEMBL
    Q3U6V6, Q3U746, Q3UBN7
    Conserved Domains (1) summary
    cl02563
    Location:1 → 69
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  10. NM_028035.4 → NP_082311.3  sorting nexin-10 isoform a

    See identical proteins and their annotated locations for NP_082311.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AK028163, AK150878, AK151320
    Consensus CDS
    CCDS20136.1
    UniProtKB/Swiss-Prot
    Q8C1E0, Q9CWT3
    UniProtKB/TrEMBL
    Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
    Related
    ENSMUSP00000110082.2, ENSMUST00000114439.8
    Conserved Domains (1) summary
    cd06898
    Location:12 → 109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    51500882..51567659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255600.2 → XP_030111460.1  sorting nexin-10 isoform X1

    UniProtKB/Swiss-Prot
    Q8C1E0, Q9CWT3
    UniProtKB/TrEMBL
    Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
    Conserved Domains (1) summary
    cd06898
    Location:12 → 109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

  2. XM_036152314.1 → XP_036008207.1  sorting nexin-10 isoform X2

    UniProtKB/TrEMBL
    Q3U6V6, Q3U746, Q3UBN7
    Conserved Domains (1) summary
    cl02563
    Location:1 → 69
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  3. XM_036152316.1 → XP_036008209.1  sorting nexin-10 isoform X2

    UniProtKB/TrEMBL
    Q3U6V6, Q3U746, Q3UBN7
    Conserved Domains (1) summary
    cl02563
    Location:1 → 69
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  4. XM_011241474.1 → XP_011239776.1  sorting nexin-10 isoform X2

    See identical proteins and their annotated locations for XP_011239776.1

    UniProtKB/TrEMBL
    Q3U6V6, Q3U746, Q3UBN7
    Conserved Domains (1) summary
    cl02563
    Location:1 → 69
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWT3.1 GenPept UniProtKB/Swiss-Prot:Q9CWT3

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