Cnpy3 canopy FGF signaling regulator 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnpy3provided by MGI
Official Full Name: canopy FGF signaling regulator 3provided by MGI
Primary source: MGI:MGI:1919279
See related: Ensembl:ENSMUSG00000023973 AllianceGenome:MGI:1919279
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAG4A; ERDA5; Tnrc5; PRAT4A; 1600025D17Rik; 2410050O22Rik
Summary: This gene encodes a member of the canopy family of proteins. The encoded protein may play a role in the maturation of toll-like receptors. Homozygous knockout mice for this gene show reduced cell surface expression of toll-like receptors and an impaired immune response including reduced production of cytokines in a mouse model of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression: Ubiquitous expression in spleen adult (RPKM 22.5), adrenal adult (RPKM 22.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 22.9 cM; 17 C

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (47046637..47063639, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (46735711..46752713, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel rare variant of CNPY3 from familial NMOSD impairs the TLR-mediated immune response.
Title: A novel rare variant of CNPY3 from familial NMOSD impairs the TLR-mediated immune response.
The SLITRK4-CNPY3 axis promotes liver metastasis of gastric cancer by enhancing the endocytosis and recycling of TrkB in tumour cells.
Title: The SLITRK4-CNPY3 axis promotes liver metastasis of gastric cancer by enhancing the endocytosis and recycling of TrkB in tumour cells.
HuR regulates Paneth cell function by modulating TLR2 localization via posttranscriptional control of CNPY3 expression.
Title: RNA-Binding Protein HuR Regulates Paneth Cell Function by Altering Membrane Localization of TLR2 via Post-transcriptional Control of CNPY3.
association with PRAT4A is required for ligand-induced trafficking of TLR9 to endolysosomes
Title: Regulatory molecules required for nucleotide-sensing Toll-like receptors.
Cell surface expression of TLR5 is dependent on PRAT4A and restricted to neutrophils, classical monocytes and specific DC subsets.
Title: PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells.
Data suggest that CNPY3 interacts with the ATP-sensitive conformation of gp96 to promote substrate loading. Our study has thus established CNPY3 as a TLR-specific cochaperone for gp96.
Title: Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone.
single base mutant associates preferentially with TLR9, and differentially interacts with TLR2, 4 and 9
Title: A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors.
PRAT4A regulates the subcellular distribution and response of multiple toll-like recaptors and is required for both innate and adaptive immune responses
Title: A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses.
PRAT4A is a novel protein associated with toll-like receptor (TLR) 4 that regulates cell surface expression of receptor complex TLR4/MD-2.
Title: A protein associated with toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein canopy homolog 3

Names: canopy 3 homolog; protein associated with Tlr4; protein associated with toll-like receptor 4; trinucleotide repeat-containing gene 5 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305988.1 → NP_001292917.1 protein canopy homolog 3 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AA028507, AK005532, AK085617, BB857917, BY245140

UniProtKB/Swiss-Prot

Q9DAU1

Conserved Domains (1) summary

pfam11938
Location:48 → 165

DUF3456; TLR4 regulator and MIR-interacting MSAP
NM_001305989.1 → NP_001292918.1 protein canopy homolog 3 isoform 3

See identical proteins and their annotated locations for NP_001292918.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an exon in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3 and 4 encode the same isoform (3).

Source sequence(s)

AA028507, AK005532, AK085617, BB857917, BY245140

UniProtKB/Swiss-Prot

Q9DAU1

Conserved Domains (1) summary

pfam11938
Location:1 → 69

DUF3456; TLR4 regulator and MIR-interacting MSAP
NM_001305990.1 → NP_001292919.1 protein canopy homolog 3 isoform 3

See identical proteins and their annotated locations for NP_001292919.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two exons in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1. Variants 3 and 4 encode the same isoform (3).

Source sequence(s)

AK082340, AK085617, BB857917

UniProtKB/Swiss-Prot

Q9DAU1

Conserved Domains (1) summary

pfam11938
Location:1 → 69

DUF3456; TLR4 regulator and MIR-interacting MSAP
NM_028065.4 → NP_082341.1 protein canopy homolog 3 isoform 1 precursor

See identical proteins and their annotated locations for NP_082341.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AA028507, AK005532, AK085617, BB857917, BY245140

Consensus CDS

CCDS28839.1

UniProtKB/Swiss-Prot

Q571I0, Q8BUS5, Q8BUV5, Q8C0C5, Q9DAU1

Related

ENSMUSP00000050309.7, ENSMUST00000059844.13

Conserved Domains (1) summary

pfam11938
Location:48 → 194

DUF3456; TLR4 regulator and MIR-interacting MSAP

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

47046637..47063639 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250060.1 → XP_030105920.1 protein canopy homolog 3 isoform X1

Conserved Domains (1) summary

pfam11938
Location:1 → 69

DUF3456; TLR4 regulator and MIR-interacting MSAP