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Sulf2 sulfatase 2 [ Mus musculus (house mouse) ]

Gene ID: 72043, updated on 5-Mar-2024

Summary

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Official Symbol
Sulf2provided by MGI
Official Full Name
sulfatase 2provided by MGI
Primary source
MGI:MGI:1919293
See related
Ensembl:ENSMUSG00000006800 AllianceGenome:MGI:1919293
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MSulf-2; mKIAA1247; 2010004N24Rik
Summary
Enables N-acetylglucosamine-6-sulfatase activity. Involved in several processes, including esophagus smooth muscle contraction; glomerular filtration; and skeletal system development. Acts upstream of or within several processes, including liver regeneration; positive regulation of canonical Wnt signaling pathway; and regulation of hepatocyte proliferation. Located in plasma membrane. Is expressed in several structures, including embryo mesenchyme; genitourinary system; limb; nervous system; and sensory organ. Orthologous to human SULF2 (sulfatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 145.3), limb E14.5 (RPKM 91.2) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H3; 2 86.31 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165915819..165997603, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (166073899..166155683, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06372 Neighboring gene STARR-seq mESC enhancer starr_06373 Neighboring gene pluripotency associated transcript 29 Neighboring gene STARR-seq mESC enhancer starr_06376 Neighboring gene STARR-positive B cell enhancer mm9_chr2:165837827-165838127 Neighboring gene nuclear receptor coactivator 3 Neighboring gene VISTA enhancer mm1346 Neighboring gene predicted gene, 52534 Neighboring gene STARR-seq mESC enhancer starr_06387 Neighboring gene predicted gene, 30320 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:166010050-166010233 Neighboring gene STARR-seq mESC enhancer starr_06391 Neighboring gene predicted gene, 30536

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockout of sulfatase 2 is associated with decreased steatohepatitis and fibrosis in a mouse model of nonalcoholic fatty liver disease. Kim TH, et al. Am J Physiol Gastrointest Liver Physiol, 2020 Sep 1. PMID 32683952, Free PMC Article
  2. Transcriptional Induction of Periostin by a Sulfatase 2-TGFβ1-SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma. Chen G, et al. Cancer Res, 2017 Feb 1. PMID 27872089, Free PMC Article
  3. Type 2 diabetes in mice induces hepatic overexpression of sulfatase 2, a novel factor that suppresses uptake of remnant lipoproteins. Chen K, et al. Hepatology, 2010 Dec. PMID 21049473, Free PMC Article
  4. Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma. Lai JP, et al. Hepatology, 2008 Apr. PMID 18318435, Free PMC Article
  5. Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches. Kerever A, et al. Glycobiology, 2021 Dec 18. PMID 34324645

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.
    Title: SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.
  2. Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches.
    Title: Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches.
  3. ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration.
    Title: ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration.
  4. Knockout of sulfatase 2 is associated with decreased steatohepatitis and fibrosis in a mouse model of nonalcoholic fatty liver disease.
    Title: Knockout of sulfatase 2 is associated with decreased steatohepatitis and fibrosis in a mouse model of nonalcoholic fatty liver disease.
  5. The extracellular sulfatase SULF2 promotes liver tumorigenesis by stimulating assembly of a promoter-looping GLI1-STAT3 transcriptional complex.
    Title: The extracellular sulfatase SULF2 promotes liver tumorigenesis by stimulating assembly of a promoter-looping GLI1-STAT3 transcriptional complex.
  6. At initiation of gliogenesis in mouse, Sulf2 is expressed in ventral neural progenitors of the embryonic spinal cord, including in Olig2-expressing cells of the pMN domain. We found that sulf2 deletion, while not affecting oligodendrocyte precursor cells production, impairs generation of a previously unknown Olig2-expressing pMN-derived cell subtype that does not upregulate Sox10, PDGFRalpha or Olig1.
    Title: Sulfatase 2 promotes generation of a spinal cord astrocyte subtype that stands out through the expression of Olig2.
  7. Shh signaling requires the coordinated activity of Sulf1 and Sulf2 in order to reach that threshold in the mouse ventral spinal cord
    Title: Sulfatase 2 Modulates Fate Change from Motor Neurons to Oligodendrocyte Precursor Cells through Coordinated Regulation of Shh Signaling with Sulfatase 1.
  8. sulfate 6-O-endosulfatase 2 expression in type II alveolar epithelial cells plays a protective role in epithelial injury, inflammation and mortality
    Title: Epithelial Deletion of Sulf2 Exacerbates Bleomycin-Induced Lung Injury, Inflammation, and Mortality.
  9. Sulf1 and Sulf2 play indispensable roles to maintain glomerular integrity and protective roles in diabetic nephropathy, probably by growth factor modulation.
    Title: Heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, regulate glomerular integrity by modulating growth factor signaling.
  10. Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, in the avian and mammalian inner ear suggests a role for sulfation during inner ear development.
    Title: Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, in the avian and mammalian inner ear suggests a role for sulfation during inner ear development.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylglucosamine-6-sulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylglucosamine-6-sulfatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables N-acetylglucosamine-6-sulfatase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables arylsulfatase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosaminoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sulfuric ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bone development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chondrocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic skeletal system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in esophagus smooth muscle contraction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glial cell-derived neurotrophic factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glomerular basement membrane development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glomerular basement membrane development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glomerular filtration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in heparan sulfate proteoglycan metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heparan sulfate proteoglycan metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heparan sulfate proteoglycan metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in innervation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in kidney development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within liver regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endothelin production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vascular endothelial growth factor production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of vascular endothelial growth factor production IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of hepatocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sulfur compound metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
extracellular sulfatase Sulf-2
Names
N-acetylglucosamine-6-sulfatase
arylsulfatase
NP_001239507.1
NP_001239508.1
NP_001342548.1
NP_082348.2
XP_006500272.1
XP_006500274.1
XP_030107960.1
XP_030107961.1
XP_036018478.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252578.1 → NP_001239507.1  extracellular sulfatase Sulf-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001239507.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 4 all encode the same isoform (1).
    Source sequence(s)
    AL589873
    Consensus CDS
    CCDS17086.1
    UniProtKB/Swiss-Prot
    B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2
    UniProtKB/TrEMBL
    Q6ZPV3
    Related
    ENSMUSP00000085405.4, ENSMUST00000088086.4
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533 → 666
    DUF3740; Sulfatase protein
    cl23718
    Location:754 → 803
    ALP_like; alkaline phosphatases and sulfatases

  2. NM_001252579.1 → NP_001239508.1  extracellular sulfatase Sulf-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate upstream start codon compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK034712, AL589873, CF736722
    UniProtKB/TrEMBL
    Q6ZPV3
    Conserved Domains (4) summary
    COG3119
    Location:76 → 420
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:573 → 699
    DUF3740; Sulfatase protein
    cd16147
    Location:76 → 418
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:787 → 836
    ALP_like; alkaline phosphatases and sulfatases

  3. NM_001355619.1 → NP_001342548.1  extracellular sulfatase Sulf-2 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (1).
    Source sequence(s)
    AL589873
    Consensus CDS
    CCDS17086.1
    UniProtKB/Swiss-Prot
    B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2
    UniProtKB/TrEMBL
    Q6ZPV3
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533 → 666
    DUF3740; Sulfatase protein
    cl23718
    Location:754 → 803
    ALP_like; alkaline phosphatases and sulfatases

  4. NM_028072.5 → NP_082348.2  extracellular sulfatase Sulf-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_082348.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (1).
    Source sequence(s)
    AK036685, AL589873, CF736722
    Consensus CDS
    CCDS17086.1
    UniProtKB/Swiss-Prot
    B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2
    UniProtKB/TrEMBL
    Q6ZPV3
    Related
    ENSMUSP00000104872.3, ENSMUST00000109249.9
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533 → 666
    DUF3740; Sulfatase protein
    cl23718
    Location:754 → 803
    ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    165915819..165997603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500209.5 → XP_006500272.1  extracellular sulfatase Sulf-2 isoform X1

    See identical proteins and their annotated locations for XP_006500272.1

    UniProtKB/Swiss-Prot
    B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2
    UniProtKB/TrEMBL
    Q6ZPV3
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533 → 666
    DUF3740; Sulfatase protein
    cl23718
    Location:754 → 803
    ALP_like; alkaline phosphatases and sulfatases

  2. XM_006500211.4 → XP_006500274.1  extracellular sulfatase Sulf-2 isoform X1

    See identical proteins and their annotated locations for XP_006500274.1

    UniProtKB/Swiss-Prot
    B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2
    UniProtKB/TrEMBL
    Q6ZPV3
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533 → 666
    DUF3740; Sulfatase protein
    cl23718
    Location:754 → 803
    ALP_like; alkaline phosphatases and sulfatases

  3. XM_030252100.1 → XP_030107960.1  extracellular sulfatase Sulf-2 isoform X1

    UniProtKB/Swiss-Prot
    B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2
    UniProtKB/TrEMBL
    Q6ZPV3
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533 → 666
    DUF3740; Sulfatase protein
    cl23718
    Location:754 → 803
    ALP_like; alkaline phosphatases and sulfatases

  4. XM_036162585.1 → XP_036018478.1  extracellular sulfatase Sulf-2 isoform X1

    UniProtKB/Swiss-Prot
    B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2
    UniProtKB/TrEMBL
    Q6ZPV3
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533 → 666
    DUF3740; Sulfatase protein
    cl23718
    Location:754 → 803
    ALP_like; alkaline phosphatases and sulfatases

  5. XM_030252101.1 → XP_030107961.1  extracellular sulfatase Sulf-2 isoform X1

    UniProtKB/Swiss-Prot
    B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2
    UniProtKB/TrEMBL
    Q6ZPV3
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533 → 666
    DUF3740; Sulfatase protein
    cl23718
    Location:754 → 803
    ALP_like; alkaline phosphatases and sulfatases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CFG0.2 GenPept UniProtKB/Swiss-Prot:Q8CFG0

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