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Aopep aminopeptidase O [ Mus musculus (house mouse) ]

Gene ID: 72061, updated on 23-Jun-2021

Summary

Official Symbol
Aopepprovided by MGI
Official Full Name
aminopeptidase Oprovided by MGI
Primary source
MGI:MGI:1919311
See related
Ensembl:ENSMUSG00000021458
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ApO; AP-O; mir-23b; mir-27b; AW742919; mir-24-1; 2010111I01Rik; 2300006M17Rik
Expression
Ubiquitous expression in bladder adult (RPKM 14.3), limb E14.5 (RPKM 9.5) and 28 other tissues See more
Orthologs
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Genomic context

See Aopep in Genome Data Viewer
Location:
13; 13 B3
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (63112707..63473910)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (62964893..63326096)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (63116294..63400964)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38679 Neighboring gene fructose bisphosphatase 1 Neighboring gene predicted gene, 40981 Neighboring gene tubulin, beta 2a, pseudogene 1 Neighboring gene predicted gene, 46422 Neighboring gene predicted gene, 30409 Neighboring gene microRNA 3074-1 Neighboring gene predicted gene, 16907 Neighboring gene microRNA 24-1 Neighboring gene microRNA 23b Neighboring gene microRNA 27b Neighboring gene Fanconi anemia, complementation group C Neighboring gene Ptch1 Hedgehog-responsive enhancers Neighboring gene patched 1 Neighboring gene predicted gene, 30655

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289924.1NP_001276853.1  aminopeptidase O

    See identical proteins and their annotated locations for NP_001276853.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC154382, AK044477, CT009757
    Consensus CDS
    CCDS36699.1
    UniProtKB/Swiss-Prot
    Q8BXQ6
    UniProtKB/TrEMBL
    Q3UQZ7
    Related
    ENSMUSP00000152528.2, ENSMUST00000220863.2
    Conserved Domains (2) summary
    pfam09127
    Location:680821
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:186634
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
  2. NM_001289926.1NP_001276855.1  aminopeptidase O

    See identical proteins and their annotated locations for NP_001276855.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate segment in the 3' UTR. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK044477, AK141931, BX520155, CT009757
    Consensus CDS
    CCDS36699.1
    UniProtKB/Swiss-Prot
    Q8BXQ6
    UniProtKB/TrEMBL
    Q3UQZ7
    Related
    ENSMUSP00000089148.5, ENSMUST00000091560.11
    Conserved Domains (2) summary
    pfam09127
    Location:680821
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:186634
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

RNA

  1. NR_110520.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' structure compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    CT009757
  2. NR_110521.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 3' and 5' structure compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC130827, AK076298, CT009757
    Related
    ENSMUST00000159152.3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    63112707..63473910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_028079.2: Suppressed sequence

    Description
    NM_028079.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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