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Palld palladin, cytoskeletal associated protein [ Mus musculus (house mouse) ]

Gene ID: 72333, updated on 23-Jun-2021

Summary

Official Symbol
Palldprovided by MGI
Official Full Name
palladin, cytoskeletal associated proteinprovided by MGI
Primary source
MGI:MGI:1919583
See related
Ensembl:ENSMUSG00000058056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6030492A02; 2410003B16Rik
Expression
Broad expression in bladder adult (RPKM 40.1), ovary adult (RPKM 20.2) and 21 other tissues See more
Orthologs
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Genomic context

See Palld in Genome Data Viewer
Location:
8; 8 B3.1
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (61964465..62355741, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (61511431..61902707, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (63993818..64381487, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene SH3 domain containing ring finger 1 Neighboring gene predicted gene, 53435 Neighboring gene carbonyl reductase 4 Neighboring gene predicted gene, 35254 Neighboring gene predicted gene, 51576 Neighboring gene lysyl-tRNA synthetase pseudogene Neighboring gene RIKEN cDNA 4930512H18 gene Neighboring gene DExD/H box helicase 60

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC150248

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables axon guidance receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in actin filament ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
palladin
Names
90kDa actin-associated protein palladin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081390.2NP_001074859.1  palladin isoform 4

    See identical proteins and their annotated locations for NP_001074859.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) lacks two alternate internal segments and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC121881, AC139846, AC147616
    Consensus CDS
    CCDS40350.1
    UniProtKB/Swiss-Prot
    Q9ET54
    Related
    ENSMUSP00000034057.8, ENSMUST00000034057.14
    Conserved Domains (3) summary
    cd00096
    Location:465542
    Ig; Immunoglobulin domain
    cd05893
    Location:10341108
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:278368
    I-set; Immunoglobulin I-set domain
  2. NM_001293772.2NP_001280701.1  palladin isoform 1

    See identical proteins and their annotated locations for NP_001280701.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC121881, AC139846, AC147616
    Consensus CDS
    CCDS80882.1
    UniProtKB/Swiss-Prot
    Q9ET54
    Related
    ENSMUSP00000112442.2, ENSMUST00000121785.9
    Conserved Domains (2) summary
    cd05893
    Location:12761350
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:278368
    I-set; Immunoglobulin I-set domain
  3. NM_001293773.2NP_001280702.1  palladin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC121881, AC147616
    Consensus CDS
    CCDS80881.1
    UniProtKB/TrEMBL
    K0BWC3
    Related
    ENSMUSP00000113874.2, ENSMUST00000121493.9
    Conserved Domains (3) summary
    cd00096
    Location:76153
    Ig; Immunoglobulin domain
    cd05893
    Location:870944
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:754844
    I-set; Immunoglobulin I-set domain
  4. NM_001293774.2NP_001280703.1  palladin isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC121881
    Consensus CDS
    CCDS80880.1
    UniProtKB/Swiss-Prot
    Q9ET54
    Related
    ENSMUSP00000112374.2, ENSMUST00000121200.9
    Conserved Domains (4) summary
    cd00096
    Location:415418
    Ig; Ig strand A [structural motif]
    cd05892
    Location:514605
    IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
    cd05893
    Location:281372
    IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:415505
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    61964465..62355741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242242.3XP_011240544.1  palladin isoform X1

    See identical proteins and their annotated locations for XP_011240544.1

    UniProtKB/Swiss-Prot
    Q9ET54
    Conserved Domains (2) summary
    cd05893
    Location:12761350
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:278368
    I-set; Immunoglobulin I-set domain
  2. XM_006509503.3XP_006509566.1  palladin isoform X2

    UniProtKB/Swiss-Prot
    Q9ET54
    Conserved Domains (2) summary
    cd05893
    Location:12591333
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:278368
    I-set; Immunoglobulin I-set domain
  3. XM_006509504.4XP_006509567.1  palladin isoform X4

    See identical proteins and their annotated locations for XP_006509567.1

    Conserved Domains (2) summary
    cd05893
    Location:887961
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:771861
    I-set; Immunoglobulin I-set domain
  4. XM_006509505.4XP_006509568.1  palladin isoform X4

    See identical proteins and their annotated locations for XP_006509568.1

    Conserved Domains (2) summary
    cd05893
    Location:887961
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:771861
    I-set; Immunoglobulin I-set domain
  5. XM_006509507.4XP_006509570.1  palladin isoform X5

    See identical proteins and their annotated locations for XP_006509570.1

    Conserved Domains (2) summary
    cd05893
    Location:548622
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:432522
    I-set; Immunoglobulin I-set domain
  6. XM_006509508.5XP_006509571.1  palladin isoform X5

    See identical proteins and their annotated locations for XP_006509571.1

    Conserved Domains (2) summary
    cd05893
    Location:548622
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:432522
    I-set; Immunoglobulin I-set domain
  7. XM_036154308.1XP_036010201.1  palladin isoform X6

    Conserved Domains (4) summary
    cd00096
    Location:415418
    Ig; Ig strand A [structural motif]
    cd05892
    Location:514605
    IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
    cd05893
    Location:281372
    IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:415505
    Ig; Immunoglobulin domain
  8. XM_036154307.1XP_036010200.1  palladin isoform X3

    Conserved Domains (6) summary
    pfam07679
    Location:448545
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:11601163
    Ig; Ig strand A [structural motif]
    cd05892
    Location:12591350
    IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
    cd05893
    Location:10261117
    IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
    cd20972
    Location:277368
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:11601250
    Ig; Immunoglobulin domain
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