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Dusp3 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) [ Mus musculus (house mouse) ]

Gene ID: 72349, updated on 23-Jun-2021

Summary

Official Symbol
Dusp3provided by MGI
Official Full Name
dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)provided by MGI
Primary source
MGI:MGI:1919599
See related
Ensembl:ENSMUSG00000003518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
V; VHR; T-DSP; T-DSP11; 2210015O03Rik; 5031436O03Rik
Expression
Ubiquitous expression in lung adult (RPKM 26.0), cortex adult (RPKM 23.2) and 28 other tissues See more
Orthologs
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Genomic context

See Dusp3 in Genome Data Viewer
Location:
11; 11 D
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101861967..101877839, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101971141..101987013, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (101835473..101846084, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930417O22 gene Neighboring gene sclerostin Neighboring gene CFAP97 domain containing 1 Neighboring gene membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MAP kinase phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP kinase phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein serine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to epidermal growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of focal adhesion disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dual specificity protein phosphatase 3
Names
vaccinia H1-related phosphatase
NP_082483.1
XP_006534368.1
XP_006534369.1
XP_030102224.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028207.3NP_082483.1  dual specificity protein phosphatase 3

    See identical proteins and their annotated locations for NP_082483.1

    Status: VALIDATED

    Source sequence(s)
    AK008734, AL591145
    Consensus CDS
    CCDS25482.1
    UniProtKB/Swiss-Prot
    Q9D7X3
    Related
    ENSMUSP00000003612.7, ENSMUST00000003612.13
    Conserved Domains (1) summary
    cd00127
    Location:29174
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    101861967..101877839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534305.3XP_006534368.1  dual specificity protein phosphatase 3 isoform X1

    Conserved Domains (1) summary
    cd14579
    Location:35202
    DUSP3; dual specificity protein phosphatase 3
  2. XM_006534306.2XP_006534369.1  dual specificity protein phosphatase 3 isoform X2

    Conserved Domains (1) summary
    cd14579
    Location:10177
    DUSP3; dual specificity protein phosphatase 3
  3. XM_030246364.2XP_030102224.1  dual specificity protein phosphatase 3 isoform X3

    Conserved Domains (1) summary
    cl28904
    Location:53111
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
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