Faim2 Fas apoptotic inhibitory molecule 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Faim2provided by MGI
Official Full Name: Fas apoptotic inhibitory molecule 2provided by MGI
Primary source: MGI:MGI:1919643
See related: Ensembl:ENSMUSG00000023011 AllianceGenome:MGI:1919643
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lfg; Lfg2; NMP25; Nmp35; Tmbim2; 2900002L20Rik
Summary: Involved in cerebellar Purkinje cell differentiation; cerebellar granular layer development; and regulation of neuron apoptotic process. Acts upstream of or within negative regulation of apoptotic signaling pathway; negative regulation of neuron apoptotic process; and response to ischemia. Located in Golgi apparatus; endoplasmic reticulum; and membrane raft. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and white fat. Orthologous to human FAIM2 (Fas apoptotic inhibitory molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 23.5), frontal lobe adult (RPKM 16.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 56.13 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (99394886..99432757, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (99497005..99534880, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Faim2 up-regulation may contribute to the neuroprotective effects of low-dose erythropoietin in transient brain ischemia
Title: Faim2 contributes to neuroprotection by erythropoietin in transient brain ischemia.
that FAIM2 is an intrinsic neuroprotective factor activated by stress in photoreceptors and delays FAS-mediated photoreceptor apoptosis
Title: FAS apoptotic inhibitory molecule 2 is a stress-induced intrinsic neuroprotective factor in the retina.
Increased degeneration of dopaminergic neurons was found in animals with Faim2 deficiency.
Title: Mice lacking Faim2 show increased cell death in the MPTP mouse model of Parkinson disease.
MiR-3202 can promote EC apoptosis in hyperglycemic conditions, which demonstrated that EC apoptosis induced by high-glucose conditions partly depends on miR-3202 targeting FAIM2.
Title: MiR-3202 - Promoted H5V Cell Apoptosis by Directly Targeting Fas Apoptotic Inhibitory Molecule 2 (FAIM2) in High Glucose Condition.
LFG plays a role in protecting T cells from apoptosis during antiviral immune response.
Title: Antiapoptotic Role for Lifeguard in T Cell Mediated Immune Response.
Data suggest Faim2/LFG (lifeguard protein) protects against FasL-/Fas ligand-induced apoptosis by down-regulating calcium release from endoplasmic reticulum in cortical neurons.
Title: Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells.
In Faim2-deficient mice, there was increased hippocampal cell death during acute bacterial meningitis.
Title: Modulation of hippocampal neuroplasticity by Fas/CD95 regulatory protein 2 (Faim2) in the course of bacterial meningitis.
Expression of Faim2 is triggered, at least in part, by Fas-receptor activation and subsequent ERK signaling.
Title: ERK-mediated activation of Fas apoptotic inhibitory molecule 2 (Faim2) prevents apoptosis of 661W cells in a model of detachment-induced photoreceptor cell death.
mechanism of action of LFG as an inhibitor of the Fas pathway and evidence of the neuroprotective role of LFG in cerebellar granule neurons and Purkinje cells in an organotypic cerebellar culture system
Title: Antiapoptotic protein Lifeguard is required for survival and maintenance of Purkinje and granular cells.
This study demonistrated that lack of Faim2 caused an increase in susceptibility to combined oxygen-glucose deprivation in primary neurons as well as in caspase-associated cell death, stroke volume, and neurological impairment after cerebral ischemia.
Title: Fas/CD95 regulatory protein Faim2 is neuroprotective after transient brain ischemia.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI854036 (e-PCR)
- UniSTS:165963

Faim2 (e-PCR), detects polymorphism
- UniSTS:496041

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebellar Purkinje cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebellar Purkinje cell layer development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebellar granular layer development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebellum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to ischemia	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein lifeguard 2

Names: neural membrane protein 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038658.2 → NP_001033747.1 protein lifeguard 2 isoform 2

See identical proteins and their annotated locations for NP_001033747.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AK030513, AK158960, BC072560, CJ283203

Consensus CDS

CCDS88840.1

UniProtKB/Swiss-Prot

Q8K097

Related

ENSMUSP00000155195.2, ENSMUST00000231171.2

Conserved Domains (1) summary

cd10428
Location:81 → 301

LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
NM_028224.4 → NP_082500.2 protein lifeguard 2 isoform 1

See identical proteins and their annotated locations for NP_082500.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK030513, AK158960, BC072560, CJ283203

Consensus CDS

CCDS37203.1

UniProtKB/Swiss-Prot

Q3TY22, Q8K097, Q8K1F6, Q9D6K4

Related

ENSMUSP00000023750.8, ENSMUST00000023750.9

Conserved Domains (1) summary

cd10428
Location:93 → 313

LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

99394886..99432757 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521449.5 → XP_006521512.1 protein lifeguard 2 isoform X1

See identical proteins and their annotated locations for XP_006521512.1

UniProtKB/Swiss-Prot

Q3TY22, Q8K097, Q8K1F6, Q9D6K4

Conserved Domains (1) summary

cd10428
Location:93 → 313

LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis