Lin9 lin-9 DREAM MuvB core complex component [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lin9provided by MGI
Official Full Name: lin-9 DREAM MuvB core complex componentprovided by MGI
Primary source: MGI:MGI:1919818
See related: Ensembl:ENSMUSG00000058729 AllianceGenome:MGI:1919818
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TGS; Bara; TGS1; Lin-9; mLin-9; 2700022J23Rik
Summary: Predicted to enable DNA binding activity. Predicted to be involved in regulation of cell cycle; regulation of transcription by RNA polymerase II; and reproduction. Predicted to act upstream of or within DNA biosynthetic process. Predicted to be located in nucleus. Predicted to be part of transcription repressor complex. Predicted to be active in nucleoplasm. Is expressed in telencephalon ventricular layer. Orthologous to human LIN9 (lin-9 DREAM MuvB core complex component). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 4.0), placenta adult (RPKM 3.7) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H4; 1 84.46 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (180468715..180518252)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (180641150..180690687)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nuclear translocation of MTL5 from cytoplasm requires its direct interaction with LIN9 and is essential for male meiosis and fertility.
Title: Nuclear translocation of MTL5 from cytoplasm requires its direct interaction with LIN9 and is essential for male meiosis and fertility.
LIN9 is essential for proliferation and genome stability of ESCs by activating genes with important functions in mitosis and cytokinesis
Title: LIN9, a subunit of the DREAM complex, regulates mitotic gene expression and proliferation of embryonic stem cells.
inactivation of LIN9, a subunit of DREAM, results in premature senescence, which can be overcome by the SV40 large T (LT) antigen
Title: Loss of LIN9, a member of the DREAM complex, cooperates with SV40 large T antigen to induce genomic instability and anchorage-independent growth.
These experiments provide the first direct genetic evidence for the role of LIN9 in development and mitotic gene regulation and they suggest that it may function as a haploinsufficient tumor suppressor.
Title: Lin9, a subunit of the mammalian DREAM complex, is essential for embryonic development, for survival of adult mice, and for tumor suppression.
there is a feedback mechanism between ARF and Mip130/LIN-9 in which either the increase of ARF or the decrease in Mip130/LIN-9
Title: ARF-induced downregulation of Mip130/LIN-9 protein levels mediates a positive feedback that leads to increased expression of p16Ink4a and p19Arf.
Mip130/LIN-9 contributes to the repression of these E2F-regulated genes in G0/G1 in mice.
Title: Deletion of the p107/p130-binding domain of Mip130/LIN-9 bypasses the requirement for CDK4 activity for the dissociation of Mip130/LIN-9 from p107/p130-E2F4 complex.
Lin-9 and B-Myb were both required for transcription of G(2)/M genes such as Cyclin B1 and Survivin.
Title: A Lin-9 complex is recruited by B-Myb to activate transcription of G2/M genes in undifferentiated embryonal carcinoma cells.
The repressor complex that Mip/LIN-9 forms with p107 takes functional precedence over the transcriptional activation linked to the Mip/LIN-9 and B-Myb interaction.
Title: Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct from the Drosophila dREAM complex.
Mip/LIN-9 is required for the expression of B-Myb, and both proteins collaborate in the control of the cell cycle progression via the regulation of S phase and cyclin A, cyclin B, and CDK1
Title: Mip/LIN-9 regulates the expression of B-Myb and the induction of cyclin A, cyclin B, and CDK1.
Mutation of BARA/LIN-9 restores the expression of E2F target genes in CDK4 null Mouse Embryo Fibroblasts, indicating that the wild-type protein plays a role in the expression of genes required for the G1/S transition.
Title: A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234279

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH124322 (e-PCR)
- UniSTS:161144

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in reproductive process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription repressor complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein lin-9 homolog

Names: TUDOR gene similar 1 protein; lin-9 homolog; type I interferon receptor beta chain-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001103182.3 → NP_001096652.3 protein lin-9 homolog

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.

Source sequence(s)

AC167020

Consensus CDS

CCDS48468.2

UniProtKB/Swiss-Prot

Q5TKA0, Q8C735, Q8C9D8

Related

ENSMUSP00000141331.3, ENSMUST00000192561.6

Conserved Domains (1) summary

pfam06584
Location:127 → 231

DIRP

RNA

NR_120498.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC167020, BC088992

Related

ENSMUST00000193892.6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

180468715..180518252

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496988.3 → XP_006497051.1 protein lin-9 homolog isoform X1

See identical proteins and their annotated locations for XP_006497051.1

UniProtKB/TrEMBL

A0A0A6YVZ7

Conserved Domains (1) summary

pfam06584
Location:75 → 179

DIRP
XM_006496987.1 → XP_006497050.1 protein lin-9 homolog isoform X1

See identical proteins and their annotated locations for XP_006497050.1

UniProtKB/TrEMBL

A0A0A6YVZ7

Conserved Domains (1) summary

pfam06584
Location:75 → 179

DIRP

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_175186.4: Suppressed sequence

Description

NM_175186.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.