U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 [ Mus musculus (house mouse) ]

Gene ID: 72685, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Dnajc6provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C6provided by MGI
Primary source
MGI:MGI:1919935
See related
Ensembl:ENSMUSG00000028528 AllianceGenome:MGI:1919935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0473; 2810027M23Rik
Summary
Predicted to enable clathrin binding activity. Involved in synaptic vesicle uncoating. Acts upstream of or within clathrin coat disassembly and regulation of clathrin-dependent endocytosis. Located in postsynaptic density. Is expressed in genital tubercle of male; gut; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 19A. Orthologous to human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 27.2), cortex adult (RPKM 25.9) and 7 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dnajc6 in Genome Data Viewer
Location:
4 C6; 4 46.89 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (101353751..101499996)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (101496648..101642799)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 0610043K17 gene Neighboring gene STARR-seq mESC enhancer starr_10903 Neighboring gene ribosomal protein L9 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10910 Neighboring gene adenylate kinase 4 Neighboring gene STARR-seq mESC enhancer starr_10915 Neighboring gene predicted gene, 36012 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:101319917-101320026 Neighboring gene STARR-positive B cell enhancer ABC_E2698 Neighboring gene leptin receptor overlapping transcript Neighboring gene STARR-seq mESC enhancer starr_10917 Neighboring gene leptin receptor

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson's disease. Vidyadhara DJ, et al. Cell Rep, 2023 Mar 28. PMID 36920906, Free PMC Article
  2. RMR-Related DNAJC6 Expression Suppresses Adipogenesis in 3T3-L1 Cells. Kim J, et al. Cells, 2022 Apr 13. PMID 35456010, Free PMC Article
  3. Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity. Farsi Z, et al. Elife, 2018 Apr 13. PMID 29652249, Free PMC Article
  4. Endocytosis and clathrin-uncoating defects at synapses of auxilin knockout mice. Yim YI, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20160091, Free PMC Article
  5. Essential role of cyclin-G-associated kinase (Auxilin-2) in developing and mature mice. Lee DW, et al. Mol Biol Cell, 2008 Jul. PMID 18434600, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gene regulation of RMR-related DNAJC6 on adipogenesis and mitochondria function in 3T3-L1 preadipocytes.
    Title: Gene regulation of RMR-related DNAJC6 on adipogenesis and mitochondria function in 3T3-L1 preadipocytes.
  2. RMR-Related DNAJC6 Expression Suppresses Adipogenesis in 3T3-L1 Cells.
    Title: RMR-Related DNAJC6 Expression Suppresses Adipogenesis in 3T3-L1 Cells.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within clathrin coat disassembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within clathrin coat disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin-dependent endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle uncoating IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle uncoating IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle uncoating IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extrinsic component of presynaptic endocytic zone membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in extrinsic component of presynaptic endocytic zone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
putative tyrosine-protein phosphatase auxilin
Names
DnaJ (Hsp40) homolog, subfamily B, member 6
DnaJ (Hsp40) homolog, subfamily C, member 6
auxilin
dnaJ homolog subfamily C member 6
NP_001158055.1
NP_001158056.1
NP_001158057.1
NP_001342108.1
NP_001342109.1
NP_940804.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164583.2 → NP_001158055.1  putative tyrosine-protein phosphatase auxilin isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL845364, BX323551
    Consensus CDS
    CCDS51238.1
    UniProtKB/Swiss-Prot
    Q80TZ3
    Related
    ENSMUSP00000102546.2, ENSMUST00000106933.2
    Conserved Domains (2) summary
    cd06257
    Location:916 → 961
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    pfam10409
    Location:281 → 419
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

  2. NM_001164584.2 → NP_001158056.1  putative tyrosine-protein phosphatase auxilin isoform b

    See identical proteins and their annotated locations for NP_001158056.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (b) with a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AL845364, BX323551
    Consensus CDS
    CCDS51237.1
    UniProtKB/Swiss-Prot
    B1B0B9, Q6P2K9, Q80TZ3, Q8C7L9
    Related
    ENSMUSP00000044251.6, ENSMUST00000038207.12
    Conserved Domains (2) summary
    cd06257
    Location:886 → 931
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    pfam10409
    Location:251 → 389
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

  3. NM_001164585.2 → NP_001158057.1  putative tyrosine-protein phosphatase auxilin isoform c

    See identical proteins and their annotated locations for NP_001158057.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream translational start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3. 4 and 6 encode the same isoform.
    Source sequence(s)
    AL845364, BX323551
    Consensus CDS
    CCDS18395.1
    UniProtKB/Swiss-Prot
    Q80TZ3
    Conserved Domains (3) summary
    cd06257
    Location:848 → 893
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    pfam10409
    Location:213 → 351
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:521 → 752
    Atrophin-1; Atrophin-1 family

  4. NM_001355179.2 → NP_001342108.1  putative tyrosine-protein phosphatase auxilin isoform d

    Status: VALIDATED

    Source sequence(s)
    AL845364, BX323551
    Conserved Domains (3) summary
    cd06257
    Location:889 → 934
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    pfam10409
    Location:254 → 392
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl25496
    Location:536 → 821
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  5. NM_001355180.2 → NP_001342109.1  putative tyrosine-protein phosphatase auxilin isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses a downstream translational start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3. 4 and 6 encode the same isoform.
    Source sequence(s)
    AL845364, BX323551
    Consensus CDS
    CCDS18395.1
    Related
    ENSMUSP00000102542.4, ENSMUST00000106929.10
    Conserved Domains (3) summary
    cd06257
    Location:848 → 893
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    pfam10409
    Location:213 → 351
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:521 → 752
    Atrophin-1; Atrophin-1 family

  6. NM_198412.3 → NP_940804.1  putative tyrosine-protein phosphatase auxilin isoform c

    See identical proteins and their annotated locations for NP_940804.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a segment of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 6 encode the same isoform.
    Source sequence(s)
    AL845364, BX323551
    Consensus CDS
    CCDS18395.1
    UniProtKB/Swiss-Prot
    Q80TZ3
    Related
    ENSMUSP00000102543.2, ENSMUST00000106930.8
    Conserved Domains (3) summary
    cd06257
    Location:848 → 893
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    pfam10409
    Location:213 → 351
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:521 → 752
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    101353751..101499996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TZ3.2 GenPept UniProtKB/Swiss-Prot:Q80TZ3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous