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Tmem135 transmembrane protein 135 [ Mus musculus (house mouse) ]

Gene ID: 72759, updated on 21-Apr-2024

Summary

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Official Symbol
Tmem135provided by MGI
Official Full Name
transmembrane protein 135provided by MGI
Primary source
MGI:MGI:1920009
See related
Ensembl:ENSMUSG00000039428 AllianceGenome:MGI:1920009
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PMP52; 2810439K08Rik
Summary
Involved in regulation of mitochondrial fission. Acts upstream of or within response to cold and response to food. Located in lipid droplet; mitochondrion; and peroxisome. Orthologous to human TMEM135 (transmembrane protein 135). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 32.4), subcutaneous fat pad adult (RPKM 19.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 D3; 7 49.32 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (88789230..89053911, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (89140022..89404703, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19485 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 6240 Neighboring gene STARR-seq mESC enhancer starr_19487 Neighboring gene STARR-positive B cell enhancer ABC_E11359 Neighboring gene STARR-positive B cell enhancer ABC_E10449 Neighboring gene STARR-seq mESC enhancer starr_19488 Neighboring gene STARR-positive B cell enhancer ABC_E4946 Neighboring gene STARR-seq mESC enhancer starr_19489 Neighboring gene STARR-seq mESC enhancer starr_19490 Neighboring gene expressed sequence AI314278 Neighboring gene frizzled class receptor 4 Neighboring gene serine protease 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups. Landowski M, et al. Sci Rep, 2022 Jan 14. PMID 35031662, Free PMC Article
  2. Modulation of Tmem135 Leads to Retinal Pigmented Epithelium Pathologies in Mice. Landowski M, et al. Invest Ophthalmol Vis Sci, 2020 Oct 1. PMID 33064130, Free PMC Article
  3. Metabolic alterations caused by the mutation and overexpression of the Tmem135 gene. Lee WH, et al. Exp Biol Med (Maywood), 2020 Nov. PMID 32515224, Free PMC Article
  4. Results from screening over 9000 mutation-bearing mice for defects in the electroretinogram and appearance of the fundus. Pinto LH, et al. Vision Res, 2004 Dec. PMID 15536001, Free PMC Article
  5. Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies. Lee WH, et al. Elife, 2016 Nov 15. PMID 27863209, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM135 maintains the equilibrium of osteogenesis and adipogenesis by regulating mitochondrial dynamics.
    Title: TMEM135 maintains the equilibrium of osteogenesis and adipogenesis by regulating mitochondrial dynamics.
  2. TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis.
    Title: TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis.
  3. Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism.
    Title: Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism.
  4. A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups.
    Title: A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups.
  5. Modulation of Tmem135 Leads to Retinal Pigmented Epithelium Pathologies in Mice.
    Title: Modulation of Tmem135 Leads to Retinal Pigmented Epithelium Pathologies in Mice.
  6. Metabolic alterations caused by the mutation and overexpression of the Tmem135 gene.
    Title: Metabolic alterations caused by the mutation and overexpression of the Tmem135 gene.
  7. The authors observed localization of TMEM135 on mitochondria, and imbalance of mitochondrial fission and fusion in mutant Tmem135 as well as Tmem135 overexpressing cells, indicating that TMEM135 is involved in the regulation of mitochondrial dynamics.
    Title: Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies.
  8. TMEM135 integrates biological processes involving fat metabolism and energy expenditure in both the worm (invertebrates) and in mammalian organisms
    Title: Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within determination of adult lifespan ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peroxisome organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of oxidative phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cold IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to cold ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within response to food IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to food ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within retinal pigment epithelium development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 135
Names
peroxisomal membrane protein 52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360745.1 → NP_001347674.1  transmembrane protein 135 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC116659, AC122386, AC123844
    Conserved Domains (1) summary
    pfam02466
    Location:160 → 212
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

  2. NM_001360746.1 → NP_001347675.1  transmembrane protein 135 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' end and lacks an alternate exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC116326, AC116659, AC122386, AC123844
    Conserved Domains (1) summary
    pfam02466
    Location:160 → 212
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

  3. NM_028343.5 → NP_082619.3  transmembrane protein 135 isoform a

    See identical proteins and their annotated locations for NP_082619.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC116659, AC122386, AK013269
    Consensus CDS
    CCDS21440.1
    UniProtKB/Swiss-Prot
    Q8BSY5, Q8CCZ6, Q8CE78, Q9CYV5
    Related
    ENSMUSP00000042783.4, ENSMUST00000041968.11
    Conserved Domains (2) summary
    pfam02466
    Location:249 → 338
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
    pfam15982
    Location:9 → 142
    TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    88789230..89053911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241911.2 → XP_011240213.1  transmembrane protein 135 isoform X2

    Conserved Domains (2) summary
    pfam02466
    Location:280 → 332
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
    pfam15982
    Location:29 → 123
    TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135

  2. XM_036153464.1 → XP_036009357.1  transmembrane protein 135 isoform X3

    Conserved Domains (1) summary
    pfam02466
    Location:171 → 223
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

  3. XM_030243017.2 → XP_030098877.1  transmembrane protein 135 isoform X3

    Conserved Domains (1) summary
    pfam02466
    Location:171 → 223
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

  4. XM_036153466.1 → XP_036009359.1  transmembrane protein 135 isoform X5

    Conserved Domains (1) summary
    pfam02466
    Location:160 → 212
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

  5. XM_036153465.1 → XP_036009358.1  transmembrane protein 135 isoform X4

    Conserved Domains (1) summary
    pfam02466
    Location:164 → 216
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

  6. XM_030243016.2 → XP_030098876.1  transmembrane protein 135 isoform X1

    Conserved Domains (2) summary
    pfam02466
    Location:384 → 436
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
    pfam15982
    Location:130 → 227
    TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135

  7. XM_030243018.2 → XP_030098878.1  transmembrane protein 135 isoform X6

    Conserved Domains (1) summary
    pfam15982
    Location:130 → 227
    TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CYV5.1 GenPept UniProtKB/Swiss-Prot:Q9CYV5

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