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Neil1 nei endonuclease VIII-like 1 (E. coli) [ Mus musculus (house mouse) ]

Gene ID: 72774, updated on 11-Apr-2024

Summary

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Official Symbol
Neil1provided by MGI
Official Full Name
nei endonuclease VIII-like 1 (E. coli)provided by MGI
Primary source
MGI:MGI:1920024
See related
Ensembl:ENSMUSG00000032298 AllianceGenome:MGI:1920024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NEH1; Nei1; 2810450N13Rik
Summary
Enables DNA N-glycosylase activity and lyase activity. Acts upstream of or within DNA repair. Located in nucleus. Is expressed in ductus deferens; embryo; epididymis; and metanephros. Used to study abdominal obesity-metabolic syndrome and obesity. Orthologous to human NEIL1 (nei like DNA glycosylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 13.5), mammary gland adult (RPKM 5.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 B; 9 30.89 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57050072..57055973, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57142788..57148688, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2700012I20 gene Neighboring gene STARR-positive B cell enhancer ABC_E9329 Neighboring gene STARR-positive B cell enhancer ABC_E711 Neighboring gene transcriptional regulator, SIN3A (yeast) Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56978348-56978531 Neighboring gene STARR-positive B cell enhancer ABC_E3832 Neighboring gene mannosidase, alpha, class 2C, member 1, opposite strand Neighboring gene mannosidase, alpha, class 2C, member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56995851-56996034 Neighboring gene STARR-positive B cell enhancer ABC_E5070 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57006119-57006228 Neighboring gene COMM domain containing 4 Neighboring gene RIKEN cDNA 1700041C23 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Endonuclease VIII-like 1 deficiency impairs survival of newly generated hippocampal neurons and memory performance in young-adult male mice. Kuo YY, et al. Life Sci, 2020 Aug 1. PMID 32437792
  2. NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress. Yang B, et al. Free Radic Biol Med, 2019 Sep. PMID 31175982, Free PMC Article
  3. NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice. Vartanian V, et al. Proc Natl Acad Sci U S A, 2017 Apr 18. PMID 28373545, Free PMC Article
  4. Enhanced sensitivity of Neil1(-/-) mice to chronic UVB exposure. Calkins MJ, et al. DNA Repair (Amst), 2016 Dec. PMID 27818081, Free PMC Article
  5. Loss of NEIL1 causes defects in olfactory function in mice. Canugovi C, et al. Neurobiol Aging, 2015 Feb. PMID 25448603, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1.
    Title: NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1.
  2. NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.
    Title: NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.
  3. DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model.
    Title: DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model.
  4. Enzymatic Hydroxylation and Excision of Extended 5-Methylcytosine Analogues.
    Title: Enzymatic Hydroxylation and Excision of Extended 5-Methylcytosine Analogues.
  5. The DNA glycosylase, Neil1, promotes successful hippocampal neurogenesis and learning and memory in young-adult mice.
    Title: Endonuclease VIII-like 1 deficiency impairs survival of newly generated hippocampal neurons and memory performance in young-adult male mice.
  6. NEIL1 plays an important role in adult mouse neurogenesis and in the resolution of neuroinflammation
    Title: NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress.
  7. Thus, NEIL1 and NEIL2 DNA glycosylases protect mitochondrial DNA against oxidative damage during neural crest differentiation.
    Title: NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress.
  8. Loss of Neil1 expression is associated with hepatocellular carcinoma.
    Title: NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice.
  9. Collectively the data suggest that NEIL1-initiated repair of a subset of ROS-induced DNA base lesions may be insufficient to prevent the initiation of inflammatory pathways during chronic UV exposure in mouse skin.
    Title: Enhanced sensitivity of Neil1(-/-) mice to chronic UVB exposure.
  10. Its loss causes defects in olfactory function.
    Title: Loss of NEIL1 causes defects in olfactory function in mice.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity, hydrolyzing N-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in base-excision repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of nuclease activity ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
endonuclease 8-like 1
Names
DNA glycosylase/AP lyase Neil1
DNA-(apurinic or apyrimidinic site) lyase Neil1
endonuclease VIII
endonuclease VIII-like 1
nei homolog 1
nei-like protein 1
NP_001344338.1
NP_082623.1
XP_006511548.1
XP_006511549.1
XP_006511550.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357409.1 → NP_001344338.1  endonuclease 8-like 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC132406
    UniProtKB/TrEMBL
    Q3U296
    Conserved Domains (3) summary
    pfam09292
    Location:189 → 227
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
    cl03119
    Location:1 → 52
    FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases
    cl26942
    Location:52 → 158
    H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain

  2. NM_028347.3 → NP_082623.1  endonuclease 8-like 1 isoform 1

    See identical proteins and their annotated locations for NP_082623.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC132406, AK013322, BC034873
    Consensus CDS
    CCDS23217.1
    UniProtKB/Swiss-Prot
    Q80V58, Q8K4Q6, Q9CYT9
    Related
    ENSMUSP00000139917.2, ENSMUST00000190245.7
    Conserved Domains (3) summary
    TIGR00577
    Location:52 → 221
    fpg; DNA-formamidopyrimidine glycosylase
    pfam09292
    Location:252 → 290
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
    cl03119
    Location:1 → 127
    FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases

RNA

  1. NR_151685.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC132406

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    57050072..57055973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511485.5 → XP_006511548.1  endonuclease 8-like 1 isoform X1

    See identical proteins and their annotated locations for XP_006511548.1

    UniProtKB/Swiss-Prot
    Q80V58, Q8K4Q6, Q9CYT9
    Conserved Domains (3) summary
    TIGR00577
    Location:52 → 221
    fpg; DNA-formamidopyrimidine glycosylase
    pfam09292
    Location:252 → 290
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
    cl03119
    Location:1 → 127
    FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases

  2. XM_006511487.5 → XP_006511550.1  endonuclease 8-like 1 isoform X2

    Conserved Domains (2) summary
    pfam09292
    Location:212 → 250
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
    cl03119
    Location:1 → 127
    FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases

  3. XM_006511486.4 → XP_006511549.1  endonuclease 8-like 1 isoform X1

    See identical proteins and their annotated locations for XP_006511549.1

    UniProtKB/Swiss-Prot
    Q80V58, Q8K4Q6, Q9CYT9
    Related
    ENSMUSP00000034842.5, ENSMUST00000034842.5
    Conserved Domains (3) summary
    TIGR00577
    Location:52 → 221
    fpg; DNA-formamidopyrimidine glycosylase
    pfam09292
    Location:252 → 290
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
    cl03119
    Location:1 → 127
    FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases

RNA

  1. XR_003948020.2 RNA Sequence

  2. XR_003948019.2 RNA Sequence

  3. XR_379461.5 RNA Sequence

  4. XR_004935575.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4Q6.3 GenPept UniProtKB/Swiss-Prot:Q8K4Q6

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