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TSPY3 testis specific protein Y-linked 3 [ Homo sapiens (human) ]

Gene ID: 728137, updated on 3-Apr-2024

Summary

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Official Symbol
TSPY3provided by HGNC
Official Full Name
testis specific protein Y-linked 3provided by HGNC
Primary source
HGNC:HGNC:33876
See related
Ensembl:ENSG00000228927 AllianceGenome:HGNC:33876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT78; TSPY; TSPY1; TSPY10
Summary
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in sex differentiation. Predicted to be located in cytoplasm. Predicted to be active in chromatin and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 34.5) See more
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Genomic context

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Location:
Yp11.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (9398421..9401217)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (9187133..9189929)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (9236030..9238826)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene testis specific protein Y-linked 7, pseudogene Neighboring gene family with sequence similarity 197 Y-linked member 6 Neighboring gene family with sequence similarity 197 Y-linked member 5 Neighboring gene testis specific protein Y-linked 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  2. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in gonadal mesoderm development IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
testis-specific Y-encoded protein 3
Names
Cancer/testis antigen 78
Testis-specific Y-encoded protein 1
Testis-specific Y-encoded protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077697.2 → NP_001071165.2  testis-specific Y-encoded protein 3

    See identical proteins and their annotated locations for NP_001071165.2

    Status: VALIDATED

    Source sequence(s)
    AC006158
    Consensus CDS
    CCDS48204.1
    UniProtKB/Swiss-Prot
    P0CV98, P0CW01
    UniProtKB/TrEMBL
    Q540R4
    Related
    ENSP00000398163.2, ENST00000457222.6
    Conserved Domains (1) summary
    cl08298
    Location:126 → 288
    NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    9398421..9401217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272742.5 → XP_005272799.1  testis-specific Y-encoded protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005272799.1

    UniProtKB/TrEMBL
    F2Z2I4, Q540R4
    Related
    ENSP00000412988.1, ENST00000424594.1
    Conserved Domains (1) summary
    cl08298
    Location:103 → 273
    NAP; Nucleosome assembly protein (NAP)

  2. XM_011544004.3 → XP_011542306.1  testis-specific Y-encoded protein 3 isoform X2

    Conserved Domains (1) summary
    cl08298
    Location:112 → 223
    NAP; Nucleosome assembly protein (NAP)

RNA

  1. XR_949063.3 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791821.1 Reference GRCh38.p14 PATCHES

    Range
    265650..268446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333418.1 → XP_054189393.1  testis-specific Y-encoded protein 3 isoform X1

    UniProtKB/TrEMBL
    F2Z2I4

  2. XM_054333419.1 → XP_054189394.1  testis-specific Y-encoded protein 3 isoform X2

RNA

  1. XR_008485839.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    9187133..9189929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328327.1 → XP_054184302.1  testis-specific Y-encoded protein 3 isoform X1

    UniProtKB/TrEMBL
    F2Z2I4

  2. XM_054328328.1 → XP_054184303.1  testis-specific Y-encoded protein 3 isoform X2

RNA

  1. XR_008485525.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CV98.1 GenPept UniProtKB/Swiss-Prot:P0CV98

Gene LinkOut

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