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Spock3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3 [ Mus musculus (house mouse) ]

Gene ID: 72902, updated on 17-Aug-2021

Summary

Official Symbol
Spock3provided by MGI
Official Full Name
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3provided by MGI
Primary source
MGI:MGI:1920152
See related
Ensembl:ENSMUSG00000054162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI428471; mKIAA4039; 2900045C01Rik
Expression
Biased expression in cerebellum adult (RPKM 13.8), cortex adult (RPKM 11.3) and 7 other tissues See more
Orthologs
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Genomic context

See Spock3 in Genome Data Viewer
Location:
8; 8 B3.1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (63404034..63810135)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (62951000..63357101)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (65430243..65835895)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 22324 Neighboring gene predicted gene, 24236 Neighboring gene methylthioadenosine phosphorylase pseudogene Neighboring gene predicted gene, 35368

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • KIAA4039

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables glycosaminoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metalloendopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252620.1NP_001239549.1  testican-3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001239549.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (1).
    Source sequence(s)
    AC122404, AC122455, AC132473, BC017601
    Consensus CDS
    CCDS22326.1
    UniProtKB/Swiss-Prot
    Q8BKV0
    Related
    ENSMUSP00000113683.2, ENSMUST00000118003.8
    Conserved Domains (4) summary
    smart00280
    Location:140183
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:316380
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:200317
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam10591
    Location:199306
    SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
  2. NM_001252621.1NP_001239550.1  testican-3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001239550.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 3 and 4 both encode the same isoform (2).
    Source sequence(s)
    AK049843, BC017601
    Consensus CDS
    CCDS57622.1
    UniProtKB/Swiss-Prot
    Q8BKV0
    Related
    ENSMUSP00000113797.2, ENSMUST00000117377.8
    Conserved Domains (3) summary
    cd00191
    Location:313377
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam07648
    Location:139180
    Kazal_2; Kazal-type serine protease inhibitor domain
    cd16239
    Location:198310
    EFh_SPARC_TICN3; EF-hand, extracellular calcium-binding (EC) motif, found in testican-3 (TICN3)
  3. NM_001361918.1NP_001348847.1  testican-3 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 3 and 4 both encode the same isoform (2).
    Source sequence(s)
    AC122404, AC122455, AC132473
    Consensus CDS
    CCDS57622.1
    Conserved Domains (3) summary
    cd00191
    Location:313377
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam07648
    Location:139180
    Kazal_2; Kazal-type serine protease inhibitor domain
    cd16239
    Location:198310
    EFh_SPARC_TICN3; EF-hand, extracellular calcium-binding (EC) motif, found in testican-3 (TICN3)
  4. NM_023689.3NP_076178.1  testican-3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_076178.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 both encode the same isoform (1).
    Source sequence(s)
    AC122404, AK220280, BC017601
    Consensus CDS
    CCDS22326.1
    UniProtKB/Swiss-Prot
    Q8BKV0
    UniProtKB/TrEMBL
    Q571A9
    Related
    ENSMUSP00000112930.2, ENSMUST00000119068.8
    Conserved Domains (4) summary
    smart00280
    Location:140183
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:316380
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:200317
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam10591
    Location:199306
    SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    63404034..63810135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509517.3XP_006509580.1  testican-3 isoform X2

    Conserved Domains (3) summary
    cd00191
    Location:329393
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd16239
    Location:214326
    EFh_SPARC_TICN3; EF-hand, extracellular calcium-binding (EC) motif, found in testican-3 (TICN3)
    pfam07648
    Location:150198
    Kazal_2; Kazal-type serine protease inhibitor domain
  2. XM_006509516.3XP_006509579.1  testican-3 isoform X1

    Conserved Domains (3) summary
    cd00191
    Location:332396
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd16239
    Location:217329
    EFh_SPARC_TICN3; EF-hand, extracellular calcium-binding (EC) motif, found in testican-3 (TICN3)
    pfam07648
    Location:153201
    Kazal_2; Kazal-type serine protease inhibitor domain
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