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Marchf1 membrane associated ring-CH-type finger 1 [ Mus musculus (house mouse) ]

Gene ID: 72925, updated on 23-Jun-2021

Summary

Official Symbol
Marchf1provided by MGI
Official Full Name
membrane associated ring-CH-type finger 1provided by MGI
Primary source
MGI:MGI:1920175
See related
Ensembl:ENSMUSG00000036469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Marc; March1; BB085186; 2900024D24Rik
Expression
Broad expression in CNS E18 (RPKM 3.6), spleen adult (RPKM 2.6) and 17 other tissues See more
Orthologs
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Genomic context

See Marchf1 in Genome Data Viewer
Location:
8; 8 B3.1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (66070550..66925761)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (65618009..66472841)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (68141939..68995536)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7624 Neighboring gene vault RNA component pseudogene 1 Neighboring gene predicted gene, 23515 Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene predicted gene, 26123 Neighboring gene predicted gene, 24205 Neighboring gene translation machinery associated 16 Neighboring gene transketolase-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MHC protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase MARCHF1
Names
E3 ubiquitin-protein ligase MARCH1
MARCH-I
RING-type E3 ubiquitin transferase MARCH1
RING-type E3 ubiquitin transferase MARCHF1
membrane-associated RING finger protein 1
membrane-associated RING-CH protein I
membrane-associated ring finger (C3HC4) 1
NP_001159844.1
NP_001159847.1
NP_001280713.1
NP_001350052.1
NP_001350053.1
NP_001350054.1
NP_780397.2
XP_006509817.1
XP_006509818.1
XP_011240631.1
XP_017168466.1
XP_017168467.1
XP_030099653.1
XP_030099654.1
XP_036010206.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166372.1NP_001159844.1  E3 ubiquitin-protein ligase MARCHF1 isoform 1

    See identical proteins and their annotated locations for NP_001159844.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate in-frame splice junction in the 3' coding sequence compared to variant 4. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 4. Variants 1 and 6 both encode the same isoform (1).
    Source sequence(s)
    AK137337, BB126406, BB662698, BE686288, BM943350
    Consensus CDS
    CCDS52560.1
    UniProtKB/Swiss-Prot
    Q6NZQ8
    Related
    ENSMUSP00000105884.2, ENSMUST00000110255.8
    Conserved Domains (1) summary
    cd16698
    Location:79130
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  2. NM_001166375.1NP_001159847.1  E3 ubiquitin-protein ligase MARCHF1 isoform 2

    See identical proteins and their annotated locations for NP_001159847.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction in the 3' coding sequence compared to variant 4. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 4.
    Source sequence(s)
    AK137337, AK152592, BB126406, BE686288, BM943350
    Consensus CDS
    CCDS52561.1
    UniProtKB/Swiss-Prot
    Q6NZQ8
    Related
    ENSMUSP00000044070.6, ENSMUST00000039540.12
    Conserved Domains (1) summary
    smart00744
    Location:69117
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  3. NM_001293784.1NP_001280713.1  E3 ubiquitin-protein ligase MARCHF1 isoform 4

    See identical proteins and their annotated locations for NP_001280713.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
    Source sequence(s)
    AC122800, AK086052, BB662698
    Consensus CDS
    CCDS80884.1
    UniProtKB/Swiss-Prot
    Q6NZQ8
    Related
    ENSMUSP00000105887.2, ENSMUST00000110258.8
    Conserved Domains (2) summary
    smart00744
    Location:79127
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
    pfam15245
    Location:40102
    VGLL4; Transcription cofactor vestigial-like protein 4
  4. NM_001363123.1NP_001350052.1  E3 ubiquitin-protein ligase MARCHF1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 4. Variants 3 and 5 both encode the same isoform (3).
    Source sequence(s)
    AC117251, AC122800, AC131655, AC139159, AC140272
    Consensus CDS
    CCDS22333.1
    Related
    ENSMUSP00000072302.7, ENSMUST00000072482.13
    Conserved Domains (1) summary
    cd16698
    Location:75126
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  5. NM_001363124.1NP_001350053.1  E3 ubiquitin-protein ligase MARCHF1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice junction compared to variant 4. Variants 1 and 6 both encode the same isoform (1).
    Source sequence(s)
    AC114634, AC117251, AC122800, AC131655, AC139159, AC140272
    Consensus CDS
    CCDS52560.1
    Conserved Domains (1) summary
    cd16698
    Location:79130
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  6. NM_001363125.1NP_001350054.1  E3 ubiquitin-protein ligase MARCHF1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 4. The resulting isoform (5) differs in the N-terminus and lacks an alternate internal segment compared to isoform 4.
    Source sequence(s)
    AC117251, AC122800, AC131655, AC139159, AC140272
    Conserved Domains (1) summary
    cd16698
    Location:75126
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  7. NM_175188.4NP_780397.2  E3 ubiquitin-protein ligase MARCHF1 isoform 3

    See identical proteins and their annotated locations for NP_780397.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate first exon and lacks an alternate internal exon compared to variant 4. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 4. Variants 3 and 5 both encode the same isoform (3).
    Source sequence(s)
    AK137337, BB126406, BC066008, BE686288, BM943350
    Consensus CDS
    CCDS22333.1
    UniProtKB/Swiss-Prot
    Q6NZQ8
    Related
    ENSMUSP00000105888.2, ENSMUST00000110259.8
    Conserved Domains (1) summary
    cd16698
    Location:75126
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    66070550..66925761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154313.1XP_036010206.1  E3 ubiquitin-protein ligase MARCHF1 isoform X6

    Conserved Domains (1) summary
    cd16698
    Location:75126
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  2. XM_030243793.2XP_030099653.1  E3 ubiquitin-protein ligase MARCHF1 isoform X5

    Conserved Domains (1) summary
    cd16698
    Location:75126
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  3. XM_030243794.2XP_030099654.1  E3 ubiquitin-protein ligase MARCHF1 isoform X5

    Conserved Domains (1) summary
    cd16698
    Location:75126
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  4. XM_017312978.3XP_017168467.1  E3 ubiquitin-protein ligase MARCHF1 isoform X5

    UniProtKB/Swiss-Prot
    Q6NZQ8
    Conserved Domains (1) summary
    cd16698
    Location:75126
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  5. XM_011242329.4XP_011240631.1  E3 ubiquitin-protein ligase MARCHF1 isoform X4

    Related
    ENSMUSP00000096305.5, ENSMUST00000098708.11
    Conserved Domains (1) summary
    cd16698
    Location:102153
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  6. XM_017312977.3XP_017168466.1  E3 ubiquitin-protein ligase MARCHF1 isoform X3

    Related
    ENSMUSP00000136545.2, ENSMUST00000178982.8
    Conserved Domains (1) summary
    cd16698
    Location:102153
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  7. XM_006509754.5XP_006509817.1  E3 ubiquitin-protein ligase MARCHF1 isoform X1

    Conserved Domains (1) summary
    cd16698
    Location:243294
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  8. XM_006509755.3XP_006509818.1  E3 ubiquitin-protein ligase MARCHF1 isoform X2

    Conserved Domains (1) summary
    cd16698
    Location:243294
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
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