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Tppp tubulin polymerization promoting protein [ Mus musculus (house mouse) ]

Gene ID: 72948, updated on 23-Jun-2021

Summary

Official Symbol
Tpppprovided by MGI
Official Full Name
tubulin polymerization promoting proteinprovided by MGI
Primary source
MGI:MGI:1920198
See related
Ensembl:ENSMUSG00000021573
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI849835; TPPP/p25; 2900041A09Rik
Expression
Biased expression in cortex adult (RPKM 75.7), frontal lobe adult (RPKM 53.9) and 10 other tissues See more
Orthologs
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Genomic context

See Tppp in Genome Data Viewer
Location:
13; 13 C1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (74157538..74183872)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (74009419..74035753)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (74146867..74173201)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger, DHHC domain containing 11 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene predicted gene 15912 Neighboring gene integrin linked kinase pseudogene Neighboring gene centrosomal protein 72 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 3 Neighboring gene predicted gene, 41003

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in astral microtubule organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule nucleation by microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in myelin assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myelin assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in oligodendrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of myelination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with microtubule bundle ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tubulin polymerization-promoting protein
Names
25 kDa brain-specific protein
brain-specific protein p25 alpha
p25-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182839.2NP_878259.1  tubulin polymerization-promoting protein

    See identical proteins and their annotated locations for NP_878259.1

    Status: VALIDATED

    Source sequence(s)
    BC054803, BM898784, BY124320
    Consensus CDS
    CCDS26638.1
    UniProtKB/Swiss-Prot
    Q7TQD2
    UniProtKB/TrEMBL
    Q3URG1
    Related
    ENSMUSP00000022057.9, ENSMUST00000022057.9
    Conserved Domains (1) summary
    pfam05517
    Location:51206
    p25-alpha

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    74157538..74183872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517409.5XP_006517472.1  tubulin polymerization-promoting protein isoform X1

    See identical proteins and their annotated locations for XP_006517472.1

    UniProtKB/Swiss-Prot
    Q7TQD2
    UniProtKB/TrEMBL
    Q3URG1
    Conserved Domains (1) summary
    pfam05517
    Location:51206
    p25-alpha
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