Tppp tubulin polymerization promoting protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tpppprovided by MGI
Official Full Name: tubulin polymerization promoting proteinprovided by MGI
Primary source: MGI:MGI:1920198
See related: Ensembl:ENSMUSG00000021573 AllianceGenome:MGI:1920198
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TPPP/p25; 2900041A09Rik
Summary: Predicted to enable several functions, including GTPase activity; magnesium ion binding activity; and protein homodimerization activity. Involved in microtubule polymerization; nervous system development; and positive regulation of myelination. Located in cytoplasm and nucleus. Colocalizes with microtubule. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and nasal cavity epithelium. Orthologous to human TPPP (tubulin polymerization promoting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 75.7), frontal lobe adult (RPKM 53.9) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C1; 13 40.15 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (74157538..74183872)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (74009419..74035753)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In vivo impact of tubulin polymerization promoting protein (Tppp) knockout to the airway inflammatory response.
Title: In vivo impact of tubulin polymerization promoting protein (Tppp) knockout to the airway inflammatory response.
Multiple system atrophy-associated oligodendroglial protein p25alpha stimulates formation of novel alpha-synuclein strain with enhanced neurodegenerative potential.
Title: Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential.
These results demonstrate that TPPP on Golgi outposts are important for local microtubule nucleation and myelin sheath elongation.
Title: The Golgi Outpost Protein TPPP Nucleates Microtubules and Is Critical for Myelination.
The present study provides additional support for roles for TPPP in the etiology of depression following early adversity.
Title: The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect.
These results support an essential role for TPPP/p25 in oligodendrocyte differentiation likely via rearrangement of the microtubule system during the process elongation prior to the onset of myelination.
Title: Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation.
A pathway was discovered by which p25 and cdk5 increases the amyloidogenic processing of amyloid precursor protein.
Title: Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing.
LIMK1 phosphorylation of p25 blocks p25 activity, thus promoting microtubule disassembly.
Title: The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ilk (e-PCR), detects polymorphism
- UniSTS:527395

AI849835 (e-PCR)
- UniSTS:180564

AA511515 (e-PCR), detects polymorphism
- UniSTS:143010

D13Mit8.1 (e-PCR), detects polymorphism
- UniSTS:127176

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule nucleator activity	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in astral microtubule organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in microtubule bundle formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule bundle formation	ISO Inferred from Sequence Orthology more info
involved_in microtubule nucleation by microtubule organizing center	ISO Inferred from Sequence Orthology more info
involved_in microtubule polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in myelin assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myelin assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tubulin deacetylation	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein polymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with microtubule	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with microtubule	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule bundle	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in postsynaptic Golgi apparatus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tubulin polymerization-promoting protein

Names: 25 kDa brain-specific protein; brain-specific protein p25 alpha; p25-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.