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ZNF726 zinc finger protein 726 [ Homo sapiens (human) ]

Gene ID: 730087, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF726provided by HGNC
Official Full Name
zinc finger protein 726provided by HGNC
Primary source
HGNC:HGNC:32462
See related
Ensembl:ENSG00000213967 AllianceGenome:HGNC:32462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF92P3
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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Location:
19p12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (23914886..23944714)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (24060450..24090278)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (24097688..24127516)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA 2 Neighboring gene uncharacterized LOC124904677 Neighboring gene zinc finger protein 726 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:24078454-24078954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:24078955-24079455 Neighboring gene uncharacterized LOC100505851 Neighboring gene RNA, 28S ribosomal pseudogene Neighboring gene Sharpr-MPRA regulatory regions 11764 and 11751 Neighboring gene Sharpr-MPRA regulatory region 3900

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A scan for positively selected genes in the genomes of humans and chimpanzees. Nielsen R, et al. PLoS Biol, 2005 Jun. PMID 15869325, Free PMC Article
  2. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. Oshikawa M, et al. Invest Ophthalmol Vis Sci, 2011 Aug 22. PMID 21697133
  3. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Martin TD, et al. Cell Rep, 2017 Jul 11. PMID 28700943, Free PMC Article
  4. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 726
Names
zinc finger protein 92 pseudogene 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001244038.2 → NP_001230967.1  zinc finger protein 726 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC011503, CN359557
    Consensus CDS
    CCDS59372.1
    UniProtKB/Swiss-Prot
    A6NNF4, M0R0X8, Q86Y87
    Related
    ENSP00000471516.1, ENST00000594466.6
    Conserved Domains (3) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:186 → 612
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:371 → 391
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001348687.2 → NP_001335616.1  zinc finger protein 726 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB593087, AC011503, CN359557
    Consensus CDS
    CCDS86738.1
    UniProtKB/TrEMBL
    F1T0F3, J3KNQ9
    Related
    ENSP00000461349.1, ENST00000575986.1
    Conserved Domains (1) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box

  3. NM_001348688.2 → NP_001335617.1  zinc finger protein 726 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC011503
    Consensus CDS
    CCDS54241.1
    UniProtKB/TrEMBL
    E9PLI7
    Related
    ENSP00000433319.2, ENST00000525354.6

  4. NM_001348689.2 → NP_001335618.1  zinc finger protein 726 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC011503
    Consensus CDS
    CCDS86739.1
    UniProtKB/TrEMBL
    A0A8I5GK09
    Related
    ENSP00000432583.2, ENST00000531821.6
    Conserved Domains (1) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    23914886..23944714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    24060450..24090278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001190829.1: Suppressed sequence

    Description
    NM_001190829.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NNF4.5 GenPept UniProtKB/Swiss-Prot:A6NNF4

Gene LinkOut

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