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Otud3 OTU domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 73162, updated on 5-Mar-2024

Summary

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Official Symbol
Otud3provided by MGI
Official Full Name
OTU domain containing 3provided by MGI
Primary source
MGI:MGI:1920412
See related
Ensembl:ENSMUSG00000041161 AllianceGenome:MGI:1920412
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3110030K17Rik
Summary
Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and protein stabilization. Predicted to act upstream of or within negative regulation of protein kinase B signaling. Predicted to be located in cytoplasm. Is expressed in axial skeleton; olfactory epithelium; pancreas; and vomeronasal organ. Orthologous to human OTUD3 (OTU deubiquitinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 16.1), colon adult (RPKM 5.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D3; 4 70.57 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138618374..138641322, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138891063..138914026, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13030 Neighboring gene phospholipase A2, group IIE Neighboring gene predicted gene, 18097 Neighboring gene predicted gene, 33011

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity. Zhang Z, et al. Mol Cell, 2020 Jul 16. PMID 32679077
  2. Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses. Cai X, et al. Cell Rep, 2022 Jun 7. PMID 35675783
  3. Deubiquitylase OTUD3 prevents Parkinson's disease through stabilizing iron regulatory protein 2. Jia F, et al. Cell Death Dis, 2022 Apr 30. PMID 35490179, Free PMC Article
  4. Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer. Wang M, et al. Nat Commun, 2021 Dec 1. PMID 34853315, Free PMC Article
  5. Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses. Zhou N, et al. Cell Metab, 2022 Jul 5. PMID 35675826

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deubiquitylase OTUD3 prevents Parkinson's disease through stabilizing iron regulatory protein 2.
    Title: Deubiquitylase OTUD3 prevents Parkinson's disease through stabilizing iron regulatory protein 2.
  2. Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses.
    Title: Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses.
  3. Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses.
    Title: Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses.
  4. Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer.
    Title: Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer.
  5. Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity.
    Title: Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity.
  6. Knockdown of OTUD3 results in a decrease in the level of GRP78 protein, suppression of cell growth and migration, and tumorigenesis in lung cancer.
    Title: The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein K11-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein K11-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein K11-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K27-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein K27-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein K48-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein K6-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein K6-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein K6-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein stabilization ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
OTU domain-containing protein 3
NP_001364018.1
NP_001364019.1
NP_001364020.1
NP_082729.1
XP_017175895.1
XP_017175896.1
XP_017175897.1
XP_030109689.1
XP_030109690.1
XP_036020376.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377089.1 → NP_001364018.1  OTU domain-containing protein 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL929473
    Conserved Domains (1) summary
    cl19932
    Location:70 → 182
    OTU; OTU-like cysteine protease

  2. NM_001377090.1 → NP_001364019.1  OTU domain-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL929473
    Conserved Domains (1) summary
    PRK10811
    Location:178 → 258
    rne; ribonuclease E; Reviewed

  3. NM_001377091.1 → NP_001364020.1  OTU domain-containing protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL929473
    Conserved Domains (1) summary
    PRK10811
    Location:86 → 166
    rne; ribonuclease E; Reviewed

  4. NM_028453.2 → NP_082729.1  OTU domain-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_082729.1

    Status: VALIDATED

    Source sequence(s)
    AL929473
    Consensus CDS
    CCDS51337.1
    UniProtKB/Swiss-Prot
    B1AZ99
    Related
    ENSMUSP00000095441.4, ENSMUST00000097830.4
    Conserved Domains (1) summary
    cl19932
    Location:70 → 182
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    138618374..138641322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320408.3 → XP_017175897.1  OTU domain-containing protein 3 isoform X2

    Conserved Domains (1) summary
    PRK10811
    Location:174 → 254
    rne; ribonuclease E; Reviewed

  2. XM_030253829.2 → XP_030109689.1  OTU domain-containing protein 3 isoform X2

    Conserved Domains (1) summary
    PRK10811
    Location:174 → 254
    rne; ribonuclease E; Reviewed

  3. XM_017320406.3 → XP_017175895.1  OTU domain-containing protein 3 isoform X1

    Conserved Domains (1) summary
    PRK10811
    Location:225 → 305
    rne; ribonuclease E; Reviewed

  4. XM_036164483.1 → XP_036020376.1  OTU domain-containing protein 3 isoform X3

    Conserved Domains (1) summary
    PRK10811
    Location:127 → 207
    rne; ribonuclease E; Reviewed

  5. XM_030253830.2 → XP_030109690.1  OTU domain-containing protein 3 isoform X3

    Conserved Domains (1) summary
    PRK10811
    Location:127 → 207
    rne; ribonuclease E; Reviewed

  6. XM_017320407.3 → XP_017175896.1  OTU domain-containing protein 3 isoform X1

    Conserved Domains (1) summary
    PRK10811
    Location:225 → 305
    rne; ribonuclease E; Reviewed
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1AZ99.1 GenPept UniProtKB/Swiss-Prot:B1AZ99

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