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Wasl WASP like actin nucleation promoting factor [ Mus musculus (house mouse) ]

Gene ID: 73178, updated on 5-Jan-2022

Summary

Official Symbol
Waslprovided by MGI
Official Full Name
WASP like actin nucleation promoting factorprovided by MGI
Primary source
MGI:MGI:1920428
See related
Ensembl:ENSMUSG00000029684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
N-WASP; 2900021I12Rik; 3110031I02Rik
Summary
Predicted to enable cytoskeletal protein binding activity and identical protein binding activity. Involved in dendritic spine morphogenesis. Acts upstream of or within several processes, including actin cytoskeleton organization; response to bacterium; and spindle localization. Located in actin cap and lamellipodium. Is expressed in brain; genitourinary system; liver; and spleen. Used to study atopic dermatitis. Orthologous to human WASL (WASP like actin nucleation promoting factor). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in bladder adult (RPKM 16.7), adrenal adult (RPKM 13.4) and 28 other tissues See more
Orthologs
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Genomic context

See Wasl in Genome Data Viewer
Location:
6; 6 A3.1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (24613809..24665185, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (24613810..24664995, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (24563810..24614995, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 15 Neighboring gene leiomodin 2 (cardiac) Neighboring gene hyaluronoglucosaminidase 6 Neighboring gene hyaluronoglucosaminidase 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
 
involved_in actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within actin nucleation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
NOT acts_upstream_of_or_within cell projection assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane invagination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lymphocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of membrane tubulation ISO
Inferred from Sequence Orthology
more info
 
involved_in plasma membrane tubulation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein-containing complex localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell projection assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spindle localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle budding from membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle organization ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle transport along actin filament ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in actin cap IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IC
Inferred by Curator
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neural Wiskott-Aldrich syndrome protein
Names
Wiskott-Aldrich syndrome-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167745.1NP_001161217.1  neural Wiskott-Aldrich syndrome protein isoform 2

    See identical proteins and their annotated locations for NP_001161217.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK014104, BC058642
    Consensus CDS
    CCDS51727.1
    UniProtKB/TrEMBL
    Q6PDL3, Q9CXQ9
    Related
    ENSMUSP00000043968.8, ENSMUST00000041737.8
    Conserved Domains (1) summary
    pfam00568
    Location:28135
    WH1; WH1 domain
  2. NM_028459.2NP_082735.2  neural Wiskott-Aldrich syndrome protein isoform 1

    See identical proteins and their annotated locations for NP_082735.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AJ318416, AK143969, BC058642, CX567238
    Consensus CDS
    CCDS19945.1
    UniProtKB/Swiss-Prot
    Q91YD9
    UniProtKB/TrEMBL
    Q3TXX8, Q6PDL3
    Related
    ENSMUSP00000031695.9, ENSMUST00000031695.15
    Conserved Domains (4) summary
    pfam00568
    Location:28135
    WH1; WH1 domain
    pfam00786
    Location:199256
    PBD; P21-Rho-binding domain
    cd22074
    Location:398424
    WH2_N-WASP_r1; first tandem Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat found in human Neural Wiskott-Aldrich syndrome protein (N-WASP) and related domains
    cd22075
    Location:425449
    WH2_hN-WASP_r2_like; second tandem Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat found in human Neural Wiskott-Aldrich syndrome protein (N-WASP) and related domains

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    24613809..24665185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152346.1XP_036008239.1  neural Wiskott-Aldrich syndrome protein isoform X1

    Conserved Domains (2) summary
    pfam00568
    Location:28135
    WH1; WH1 domain
    pfam00786
    Location:199256
    PBD; P21-Rho-binding domain
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