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Rassf6 Ras association (RalGDS/AF-6) domain family member 6 [ Mus musculus (house mouse) ]

Gene ID: 73246, updated on 25-Jan-2022

Summary

Official Symbol
Rassf6provided by MGI
Official Full Name
Ras association (RalGDS/AF-6) domain family member 6provided by MGI
Primary source
MGI:MGI:1920496
See related
Ensembl:ENSMUSG00000029370 AllianceGenome:MGI:1920496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1600016B17Rik
Summary
Involved in regulation of apoptotic process. Acts upstream of or within positive regulation of apoptotic process. Is expressed in gut; liver lobe; urinary system; and vibrissa. Orthologous to human RASSF6 (Ras association domain family member 6). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in placenta adult (RPKM 6.2), colon adult (RPKM 3.6) and 15 other tissues See more
Orthologs
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Genomic context

See Rassf6 in Genome Data Viewer
Location:
5; 5 E1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (90750935..90788594, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (90603076..90640734, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (91032102..91069513, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger, BED domain containing 4 pseudogene Neighboring gene albumin superfamily member 1 Neighboring gene predicted gene, 42109 Neighboring gene predicted gene, 36084 Neighboring gene chemokine (C-X-C motif) ligand 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
ras association domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310656.1NP_001297585.1  ras association domain-containing protein 6 isoform 2

    See identical proteins and their annotated locations for NP_001297585.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK132288, BY792116
    Consensus CDS
    CCDS80327.1
    UniProtKB/Swiss-Prot
    Q80UQ2
    Related
    ENSMUSP00000144337.2, ENSMUST00000202784.4
    Conserved Domains (2) summary
    pfam16517
    Location:278316
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl00155
    Location:178264
    UBQ; Ubiquitin-like proteins
  2. NM_028478.3NP_082754.2  ras association domain-containing protein 6 isoform 1

    See identical proteins and their annotated locations for NP_082754.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC135240
    Consensus CDS
    CCDS39142.1
    UniProtKB/TrEMBL
    G3X8Z9
    Related
    ENSMUSP00000031317.7, ENSMUST00000031317.10
    Conserved Domains (2) summary
    pfam16517
    Location:291329
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:191277
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    90750935..90788594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249579.4XP_011247881.1  ras association domain-containing protein 6 isoform X5

    See identical proteins and their annotated locations for XP_011247881.1

    Conserved Domains (1) summary
    cl28922
    Location:38124
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  2. XM_036165544.1XP_036021437.1  ras association domain-containing protein 6 isoform X5

    Conserved Domains (1) summary
    cl28922
    Location:38124
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  3. XM_006535246.5XP_006535309.1  ras association domain-containing protein 6 isoform X3

    See identical proteins and their annotated locations for XP_006535309.1

    UniProtKB/TrEMBL
    G3X8Z9
    Related
    ENSMUSP00000144532.2, ENSMUST00000202704.4
    Conserved Domains (2) summary
    pfam16517
    Location:291329
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:191277
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  4. XM_006535247.5XP_006535310.1  ras association domain-containing protein 6 isoform X3

    See identical proteins and their annotated locations for XP_006535310.1

    UniProtKB/TrEMBL
    G3X8Z9
    Conserved Domains (2) summary
    pfam16517
    Location:291329
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:191277
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  5. XM_006535245.4XP_006535308.1  ras association domain-containing protein 6 isoform X3

    See identical proteins and their annotated locations for XP_006535308.1

    UniProtKB/TrEMBL
    G3X8Z9
    Conserved Domains (2) summary
    pfam16517
    Location:291329
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:191277
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  6. XM_006535244.4XP_006535307.1  ras association domain-containing protein 6 isoform X2

    Conserved Domains (2) summary
    pfam16517
    Location:307345
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:207293
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  7. XM_006535241.3XP_006535304.1  ras association domain-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006535304.1

    Conserved Domains (2) summary
    pfam16517
    Location:320358
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:220306
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  8. XM_006535249.4XP_006535312.1  ras association domain-containing protein 6 isoform X4

    Conserved Domains (2) summary
    pfam16517
    Location:233271
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:133219
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  9. XM_006535243.5XP_006535306.1  ras association domain-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006535306.1

    Conserved Domains (2) summary
    pfam16517
    Location:320358
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:220306
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  10. XM_006535242.5XP_006535305.1  ras association domain-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006535305.1

    Conserved Domains (2) summary
    pfam16517
    Location:320358
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:220306
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RNA

  1. XR_001784751.2 RNA Sequence

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