brca1 breast cancer 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: brca1provided by Xenbase
Official Full Name: breast cancer 1provided by Xenbase
Primary source: Xenbase:XB-GENE-490624
See related: Ensembl:ENSXETG00000024564
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: iris; pscp; brcai; brcc1; rnf53
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	10	NC_030686.2 (19544261..19614820, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	10	NC_030686.1 (16617464..16686888)

Chromosome 10 - NC_030686.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: breast cancer type 1 susceptibility protein

Names: breast and ovarian cancer susceptibility protein; breast cancer 1, early onset

NP_001107963.1

EC 2.3.2.27

XP_012807962.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114491.1 → NP_001107963.1 breast cancer type 1 susceptibility protein

See identical proteins and their annotated locations for NP_001107963.1

Status: PROVISIONAL

Source sequence(s)

BC159159

UniProtKB/TrEMBL

B0JZF7, F6TA60

Related

ENSXETP00000021462.5, ENSXETT00000021462.5

Conserved Domains (4) summary

smart00292
Location:1496 → 1579

BRCT; breast cancer carboxy-terminal domain

cd00162
Location:18 → 64

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00533
Location:1384 → 1459

BRCT; BRCA1 C Terminus (BRCT) domain

pfam12820
Location:345 → 437

BRCT_assoc; Serine-rich domain associated with BRCT

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030686.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

19544261..19614820 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_012952508.3 → XP_012807962.2 breast cancer type 1 susceptibility protein isoform X1

UniProtKB/TrEMBL

A0A6I8PS34, F6TA60

Related

ENSXETP00000063009.3, ENSXETT00000064158.3

Conserved Domains (5) summary

TIGR00599
Location:80 → 186

rad18; DNA repair protein rad18

cd16498
Location:76 → 124

RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

cd17721
Location:1558 → 1655

BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

cd17735
Location:1449 → 1545

BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

pfam12820
Location:408 → 500

BRCT_assoc; Serine-rich domain associated with BRCT