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Rec114 REC114 meiotic recombination protein [ Mus musculus (house mouse) ]

Gene ID: 73673, updated on 5-Mar-2024

Summary

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Official Symbol
Rec114provided by MGI
Official Full Name
REC114 meiotic recombination proteinprovided by MGI
Primary source
MGI:MGI:1920923
See related
Ensembl:ENSMUSG00000074269 AllianceGenome:MGI:1920923
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410076I21Rik; 4930527A11Rik
Summary
Predicted to act upstream of or within DNA recombination and meiotic cell cycle. Is expressed in inner cell mass; ovary; primary oocyte; and secondary oocyte. Orthologous to human REC114 (REC114 meiotic recombination protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 6.3), large intestine adult (RPKM 6.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 B; 9 31.79 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (58560139..58729684, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (58652856..58822706, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene inhibitory synaptic factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E6742 Neighboring gene predicted gene, 53528 Neighboring gene CD276 antigen Neighboring gene STARR-positive B cell enhancer ABC_E1387 Neighboring gene neuroplastin Neighboring gene predicted gene 20620 Neighboring gene STARR-seq mESC enhancer starr_24285 Neighboring gene predicted gene, 21183 Neighboring gene VISTA enhancer mm1997 Neighboring gene STARR-seq mESC enhancer starr_24288 Neighboring gene hyperpolarization-activated, cyclic nucleotide-gated K+ 4 Neighboring gene neogenin Neighboring gene STARR-seq mESC enhancer starr_24289 Neighboring gene STARR-seq mESC enhancer starr_24290 Neighboring gene STARR-seq mESC enhancer starr_24291

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks. Nore A, et al. Nat Commun, 2022 Nov 17. PMID 36396648, Free PMC Article
  2. REC114 Partner ANKRD31 Controls Number, Timing, and Location of Meiotic DNA Breaks. Boekhout M, et al. Mol Cell, 2019 Jun 6. PMID 31003867, Free PMC Article
  3. Causative Mutations and Mechanism of Androgenetic Hydatidiform Moles. Nguyen NMP, et al. Am J Hum Genet, 2018 Nov 1. PMID 30388401, Free PMC Article
  4. Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes. Papanikos F, et al. Mol Cell, 2019 Jun 6. PMID 31000436
  5. Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4. Kumar R, et al. Life Sci Alliance, 2018 Dec. PMID 30569039, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Essential roles of the ANKRD31-REC114 interaction in meiotic recombination and mouse spermatogenesis.
    Title: Essential roles of the ANKRD31-REC114 interaction in meiotic recombination and mouse spermatogenesis.
  2. Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation.
    Title: Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation.
  3. TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks.
    Title: TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks.
  4. A crystal structure defines a pleckstrin homology (PH) domain in REC114 and its direct intermolecular contacts with ANKRD31. In vivo, ANKRD31 stabilizes REC114 association with the PAR and elsewhere. Our findings inform a model in which ANKRD31 is a scaffold anchoring REC114 and other factors to specific genomic locations, thereby regulating DSB formation.
    Title: REC114 Partner ANKRD31 Controls Number, Timing, and Location of Meiotic DNA Breaks.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in meiotic DNA double-strand break formation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in oogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermatogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
meiotic recombination protein REC114

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028598.1 → NP_082874.1  meiotic recombination protein REC114

    See identical proteins and their annotated locations for NP_082874.1

    Status: VALIDATED

    Source sequence(s)
    AK010725, AV474073, BY715467
    Consensus CDS
    CCDS52814.1
    UniProtKB/Swiss-Prot
    Q9CWH4
    Related
    ENSMUSP00000096271.5, ENSMUST00000098674.6
    Conserved Domains (1) summary
    pfam15165
    Location:20 → 254
    REC114-like; Meiotic recombination protein REC114-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    58560139..58729684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155335.1 → XP_036011228.1  meiotic recombination protein REC114 isoform X7

    Conserved Domains (1) summary
    pfam15165
    Location:1 → 195
    REC114-like; Meiotic recombination protein REC114-like

  2. XM_036155336.1 → XP_036011229.1  meiotic recombination protein REC114 isoform X7

    Conserved Domains (1) summary
    pfam15165
    Location:1 → 195
    REC114-like; Meiotic recombination protein REC114-like

  3. XM_036155333.1 → XP_036011226.1  meiotic recombination protein REC114 isoform X4

    Conserved Domains (1) summary
    pfam15165
    Location:20 → 264
    REC114-like; Meiotic recombination protein REC114-like

  4. XM_036155332.1 → XP_036011225.1  meiotic recombination protein REC114 isoform X3

    Conserved Domains (1) summary
    pfam15165
    Location:20 → 266
    REC114-like; Meiotic recombination protein REC114-like

  5. XM_011242822.2 → XP_011241124.1  meiotic recombination protein REC114 isoform X2

    Conserved Domains (1) summary
    pfam15165
    Location:20 → 266
    REC114-like; Meiotic recombination protein REC114-like

  6. XM_011242820.2 → XP_011241122.1  meiotic recombination protein REC114 isoform X1

    Conserved Domains (1) summary
    pfam15165
    Location:20 → 294
    REC114-like; Meiotic recombination protein REC114-like

  7. XM_036155334.1 → XP_036011227.1  meiotic recombination protein REC114 isoform X5

    Conserved Domains (1) summary
    pfam15165
    Location:17 → 228
    REC114-like; Meiotic recombination protein REC114-like

  8. XM_006511491.4 → XP_006511554.1  meiotic recombination protein REC114 isoform X6

    Conserved Domains (1) summary
    pfam15165
    Location:20 → 208
    REC114-like; Meiotic recombination protein REC114-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWH4.1 GenPept UniProtKB/Swiss-Prot:Q9CWH4

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