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Dppa2 developmental pluripotency associated 2 [ Mus musculus (house mouse) ]

Gene ID: 73703, updated on 5-Mar-2024

Summary

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Official Symbol
Dppa2provided by MGI
Official Full Name
developmental pluripotency associated 2provided by MGI
Primary source
MGI:MGI:2157523
See related
Ensembl:ENSMUSG00000072419 AllianceGenome:MGI:2157523
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D19Mgi18; ECAT15-2; 2410088E07Rik
Summary
Enables chromatin binding activity. Acts upstream of or within several processes, including lung-associated mesenchyme development; positive regulation of stem cell proliferation; and regulation of histone methylation. Located in nucleus. Is expressed in several structures, including early conceptus; gonad; liver; primordial germ cell; and trunk. Orthologous to human DPPA2 (developmental pluripotency associated 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
16 B5; 16 30.75 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (48130637..48139876)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (48310274..48319513)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40940 Neighboring gene STARR-seq mESC enhancer starr_40944 Neighboring gene developmental pluripotency associated 4 Neighboring gene predicted gene 5485 Neighboring gene STARR-seq mESC enhancer starr_40947 Neighboring gene microrchidia 1 Neighboring gene STARR-seq mESC enhancer starr_40948 Neighboring gene STARR-seq mESC enhancer starr_40950 Neighboring gene STARR-seq mESC enhancer starr_40952 Neighboring gene STARR-seq mESC enhancer starr_40956 Neighboring gene predicted gene, 41458

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dppa2 knockdown-induced differentiation and repressed proliferation of mouse embryonic stem cells. Du J, et al. J Biochem, 2010 Feb. PMID 19846433
  2. Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development. Gretarsson KH, et al. Nat Struct Mol Biol, 2020 Aug. PMID 32572256
  3. Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment. Eckersley-Maslin MA, et al. Nat Struct Mol Biol, 2020 Aug. PMID 32572255, Free PMC Article
  4. Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome. Lim PSL, et al. Nat Struct Mol Biol, 2020 Aug. PMID 32572253
  5. DPPA2 and DPPA4 are necessary to establish a 2C-like state in mouse embryonic stem cells. De Iaco A, et al. EMBO Rep, 2019 May. PMID 30948459, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival.
    Title: Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival.
  2. DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development.
    Title: DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development.
  3. Dppa2/4 as a trigger of signaling pathways to promote zygote genome activation by binding to CG-rich region.
    Title: Dppa2/4 as a trigger of signaling pathways to promote zygote genome activation by binding to CG-rich region.
  4. Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development.
    Title: Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development.
  5. Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment.
    Title: Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment.
  6. Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome.
    Title: Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome.
  7. The paralog proteins DPPA2 and DPPA4 as necessary for the activation of Dux and LINE-1 expression in mESCs.
    Title: DPPA2 and DPPA4 are necessary to establish a 2C-like state in mouse embryonic stem cells.
  8. Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency
    Title: Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency.
  9. Dppa2 and Dppa4 directly regulate the 2C-like cell population and associated transcripts, including Dux and the Zscan4 cluster.
    Title: Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program.
  10. a novel long non-coding RNA was found to silence its neighboring gene, Dppa2, in cis through recruiting Dnmt1, Dnmt3a and Dnmt3b
    Title: LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within epigenetic regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lung-associated mesenchyme development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lung-associated mesenchyme development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
developmental pluripotency-associated protein 2
Names
embryonic stem cell-associated transcript 15-2 protein
pluripotent embryonic stem cell-related gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028615.1 → NP_082891.1  developmental pluripotency-associated protein 2

    See identical proteins and their annotated locations for NP_082891.1

    Status: PROVISIONAL

    Source sequence(s)
    AY561246
    Consensus CDS
    CCDS37350.1
    UniProtKB/Swiss-Prot
    Q9CWH0
    UniProtKB/TrEMBL
    B2RQ54
    Related
    ENSMUSP00000110183.4, ENSMUST00000097175.5
    Conserved Domains (3) summary
    smart00513
    Location:91 → 118
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14047
    Location:211 → 277
    DCR; Dppa2/4 conserved region
    pfam14049
    Location:126 → 206
    Dppa2_A; Dppa2/4 conserved region in higher vertebrates

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    48130637..48139876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWH0.1 GenPept UniProtKB/Swiss-Prot:Q9CWH0

Gene LinkOut

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