Kif2c kinesin family member 2C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif2cprovided by MGI
Official Full Name: kinesin family member 2Cprovided by MGI
Primary source: MGI:MGI:1921054
See related: Ensembl:ENSMUSG00000028678 AllianceGenome:MGI:1921054
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MCAK; ESTM5; Knsl6; 4930402F02Rik
Summary: Predicted to enable ATP hydrolysis activity; microtubule motor activity; and microtubule plus-end binding activity. Predicted to be involved in several processes, including attachment of mitotic spindle microtubules to kinetochore; microtubule cytoskeleton organization; and regulation of chromosome segregation. Predicted to act upstream of or within cell division and chromosome segregation. Located in chromosome, centromeric region. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human KIF2C (kinesin family member 2C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 63.2), CNS E11.5 (RPKM 19.8) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D1; 4 53.42 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (117016830..117039821, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (117159633..117182624, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ablation of KIF2C in Purkinje cells impairs metabotropic glutamate receptor trafficking and motor coordination in male mice.
Title: Ablation of KIF2C in Purkinje cells impairs metabotropic glutamate receptor trafficking and motor coordination in male mice.
KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization.
Title: KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization.
Clathrin's adaptor interaction sites are repurposed to stabilize microtubules during mitosis.
Title: Clathrin's adaptor interaction sites are repurposed to stabilize microtubules during mitosis.
PAK1 phosphorylates MCAK and regulates both its localization and function.
Title: Signaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localization.
MCAK appears to possess a unique distribution and function in oocyte maturation.
Title: MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes.
MCAK contributes to chromosome alignment in meiosis I, but is not necessary for preventing chromosome segregation errors.
Title: MCAK regulates chromosome alignment but is not necessary for preventing aneuploidy in mouse oocyte meiosis I.
Shugoshin 2 is necessary for the loading of MCAK at the inner centromere, but is dispensable for the loading of the outer kinetochore proteins BubR1 and CENP-E.
Title: Sequential assembly of centromeric proteins in male mouse meiosis.
Possible functions of MCAK at the inner centromere domain and at the perikinetochoric ring during both meiotic divisions.
Title: A perikinetochoric ring defined by MCAK and Aurora-B as a novel centromere domain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule plus-end binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in establishment or maintenance of microtubule cytoskeleton polarity	ISO Inferred from Sequence Orthology more info
involved_in metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in microtubule plus-end	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in spindle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kinesin-like protein KIF2C

Names: kinesin-like 6; mitotic centromere-associated kinesin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290662.1 → NP_001277591.1 kinesin-like protein KIF2C isoform 2

See identical proteins and their annotated locations for NP_001277591.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK161309, AL671866

Consensus CDS

CCDS71452.1

UniProtKB/TrEMBL

Q3TTL2, Q8BU22

Conserved Domains (1) summary

cd01367
Location:203 → 531

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
NM_134471.4 → NP_608301.3 kinesin-like protein KIF2C isoform 1

See identical proteins and their annotated locations for NP_608301.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK150222, AK161309, CF163926, CK381255, CO798410

Consensus CDS

CCDS18531.1

UniProtKB/Swiss-Prot

A2AE71, Q922S8

UniProtKB/TrEMBL

Q8BU22

Related

ENSMUSP00000064261.3, ENSMUST00000065896.9

Conserved Domains (2) summary

cd01367
Location:254 → 582

KISc_KIF2_like; Kinesin motor domain, KIF2-like group

pfam00225
Location:260 → 583

Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

117016830..117039821 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240621.2 → XP_011238923.1 kinesin-like protein KIF2C isoform X1

See identical proteins and their annotated locations for XP_011238923.1

UniProtKB/TrEMBL

Q8BU22

Conserved Domains (1) summary

cd01367
Location:206 → 534

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
XM_006503435.4 → XP_006503498.1 kinesin-like protein KIF2C isoform X2

See identical proteins and their annotated locations for XP_006503498.1

UniProtKB/TrEMBL

Q3TTL2, Q8BU22

Conserved Domains (1) summary

cd01367
Location:203 → 531

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
XM_017320411.2 → XP_017175900.1 kinesin-like protein KIF2C isoform X1

UniProtKB/TrEMBL

Q8BU22

Conserved Domains (1) summary

cd01367
Location:206 → 534

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
XM_030253838.2 → XP_030109698.1 kinesin-like protein KIF2C isoform X2

UniProtKB/TrEMBL

Q3TTL2, Q8BU22

Conserved Domains (1) summary

cd01367
Location:203 → 531

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
XM_011240620.3 → XP_011238922.1 kinesin-like protein KIF2C isoform X1

See identical proteins and their annotated locations for XP_011238922.1

UniProtKB/TrEMBL

Q8BU22

Conserved Domains (1) summary

cd01367
Location:206 → 534

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
XM_011240622.3 → XP_011238924.1 kinesin-like protein KIF2C isoform X2

See identical proteins and their annotated locations for XP_011238924.1

UniProtKB/TrEMBL

Q3TTL2, Q8BU22

Related

ENSMUSP00000102044.2, ENSMUST00000106436.8

Conserved Domains (1) summary

cd01367
Location:203 → 531

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
XM_006503433.3 → XP_006503496.1 kinesin-like protein KIF2C isoform X1

See identical proteins and their annotated locations for XP_006503496.1

UniProtKB/TrEMBL

Q8BU22

Conserved Domains (1) summary

cd01367
Location:206 → 534

KISc_KIF2_like; Kinesin motor domain, KIF2-like group