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Npl N-acetylneuraminate pyruvate lyase [ Mus musculus (house mouse) ]

Gene ID: 74091, updated on 25-Jan-2022

Summary

Official Symbol
Nplprovided by MGI
Official Full Name
N-acetylneuraminate pyruvate lyaseprovided by MGI
Primary source
MGI:MGI:1921341
See related
Ensembl:ENSMUSG00000042684 AllianceGenome:MGI:1921341
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610033B02Rik
Summary
Enables N-acetylneuraminate lyase activity. Predicted to be involved in N-acetylneuraminate catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in cytoplasm. Is expressed in 2-cell stage embryo; eye; and nervous system. Orthologous to human NPL (N-acetylneuraminate pyruvate lyase). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in placenta adult (RPKM 95.4), kidney adult (RPKM 16.6) and 1 other tissue See more
Orthologs
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Genomic context

See Npl in Genome Data Viewer
Location:
1; 1 G3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (153378762..153425460, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (153503016..153549714, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (155350146..155396844, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Shc SH2-domain binding protein 1-like Neighboring gene predicted gene, 25588 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 9 Neighboring gene predicted gene 6652 Neighboring gene regulator of G-protein signaling 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylneuraminate lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables N-acetylneuraminate lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables N-acetylneuraminate lyase activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in N-acetylneuraminate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in N-acetylneuraminate catabolic process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
N-acetylneuraminate lyase
Names
N-acetylneuraminic acid aldolase
NALase
sialate lyase
sialate-pyruvate lyase
sialic acid aldolase
sialic acid lyase
NP_083025.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028749.1NP_083025.1  N-acetylneuraminate lyase

    See identical proteins and their annotated locations for NP_083025.1

    Status: PROVISIONAL

    Source sequence(s)
    AK002734
    Consensus CDS
    CCDS15374.1
    UniProtKB/Swiss-Prot
    Q9DCJ9
    Related
    ENSMUSP00000037454.8, ENSMUST00000041874.9
    Conserved Domains (1) summary
    cl21457
    Location:8306
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    153378762..153425460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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