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Dcaf6 DDB1 and CUL4 associated factor 6 [ Mus musculus (house mouse) ]

Gene ID: 74106, updated on 23-Jun-2021

Summary

Official Symbol
Dcaf6provided by MGI
Official Full Name
DDB1 and CUL4 associated factor 6provided by MGI
Primary source
MGI:MGI:1921356
See related
Ensembl:ENSMUSG00000026571
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Iqwd; PC32; Iqwd1; PC326; 1200006M05Rik
Expression
Ubiquitous expression in testis adult (RPKM 41.3), cortex adult (RPKM 13.4) and 27 other tissues See more
Orthologs
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Genomic context

See Dcaf6 in Genome Data Viewer
Location:
1; 1 H2.2- H2.3
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165157069..165288475, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165329500..165460906, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (167259631..167390594, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene SFT2 domain containing 2 Neighboring gene TIP41, TOR signalling pathway regulator-like (S. cerevisiae) Neighboring gene G protein-coupled receptor 161 Neighboring gene predicted gene, 24637 Neighboring gene mitochondrial pyruvate carrier 2 Neighboring gene adenylate cyclase 10 Neighboring gene peptidylprolyl isomerase A pseudogene 1_1625.1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DDB1- and CUL4-associated factor 6
Names
IQ motif and WD repeat-containing protein 1
IQ motif and WD repeats 1
NRIP
nuclear receptor interaction protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028759.1NP_083035.1  DDB1- and CUL4-associated factor 6

    See identical proteins and their annotated locations for NP_083035.1

    Status: VALIDATED

    Source sequence(s)
    AC116374, AC162789
    Consensus CDS
    CCDS48424.1
    UniProtKB/Swiss-Prot
    Q9DC22
    Related
    ENSMUSP00000027856.8, ENSMUST00000027856.13
    Conserved Domains (3) summary
    COG2319
    Location:42281
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:5592
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:43292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    165157069..165288475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243204.1XP_030099064.1  DDB1- and CUL4-associated factor 6 isoform X7

    Conserved Domains (2) summary
    sd00039
    Location:4899
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_036153945.1XP_036009838.1  DDB1- and CUL4-associated factor 6 isoform X8

    Conserved Domains (1) summary
    cl29593
    Location:599658
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_036153915.1XP_036009808.1  DDB1- and CUL4-associated factor 6 isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:5592
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:43292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_036153926.1XP_036009819.1  DDB1- and CUL4-associated factor 6 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:5592
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:43292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_036153932.1XP_036009825.1  DDB1- and CUL4-associated factor 6 isoform X5

    Conserved Domains (2) summary
    sd00039
    Location:5592
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:43292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_036153933.1XP_036009826.1  DDB1- and CUL4-associated factor 6 isoform X6

    Conserved Domains (2) summary
    sd00039
    Location:4899
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. XM_036153936.1XP_036009829.1  DDB1- and CUL4-associated factor 6 isoform X6

    Conserved Domains (2) summary
    sd00039
    Location:4899
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. XM_006497004.3XP_006497067.1  DDB1- and CUL4-associated factor 6 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:5592
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:43292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  9. XM_006497005.3XP_006497068.1  DDB1- and CUL4-associated factor 6 isoform X4

    Conserved Domains (2) summary
    sd00039
    Location:5592
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:43292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  10. XM_006497008.3XP_006497071.1  DDB1- and CUL4-associated factor 6 isoform X9

    Conserved Domains (2) summary
    sd00039
    Location:5592
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:43292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  11. XM_036153948.1XP_036009841.1  DDB1- and CUL4-associated factor 6 isoform X9

    Conserved Domains (2) summary
    sd00039
    Location:5592
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:43292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_004934804.1 RNA Sequence

  2. XR_004934805.1 RNA Sequence

  3. XR_373618.3 RNA Sequence

  4. XR_004934806.1 RNA Sequence

  5. XR_001778389.3 RNA Sequence

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