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Foxp4 forkhead box P4 [ Mus musculus (house mouse) ]

Gene ID: 74123, updated on 21-Apr-2024

Summary

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Official Symbol
Foxp4provided by MGI
Official Full Name
forkhead box P4provided by MGI
Primary source
MGI:MGI:1921373
See related
Ensembl:ENSMUSG00000023991 AllianceGenome:MGI:1921373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mFKHLA; 1200010K03Rik; 2310007G05Rik
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within several processes, including embryonic foregut morphogenesis; lung secretory cell differentiation; and negative regulation of lung goblet cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; hindlimb digit mesenchyme; and skeleton. Orthologous to human FOXP4 (forkhead box P4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in stomach adult (RPKM 50.9), colon adult (RPKM 45.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 C; 17 23.99 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48178058..48235401, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47867133..47924632, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25201 Neighboring gene nuclear encoded rRNA 5S 28 Neighboring gene STARR-seq mESC enhancer starr_42731 Neighboring gene STARR-seq mESC enhancer starr_42732 Neighboring gene STARR-seq mESC enhancer starr_42734 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48037747-48037856 Neighboring gene STARR-positive B cell enhancer ABC_E8679 Neighboring gene STARR-positive B cell enhancer ABC_E9170 Neighboring gene macrophage migration inhibitory factor, pseudogene 8 Neighboring gene predicted gene, 29938

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inhibition of Foxp4 Disrupts Cadherin-based Adhesion of Radial Glial Cells, Leading to Abnormal Differentiation and Migration of Cortical Neurons in Mice. Li X, et al. Neurosci Bull, 2023 Jul. PMID 36646976,
  2. FOXP4 differentially controls cold-induced beige adipocyte differentiation and thermogenesis. Wang F, et al. Development, 2022 Apr 1. PMID 35297993
  3. Foxp1 and Foxp4 Deletion Causes the Loss of Follicle Stem Cell Niche and Cyclic Hair Shedding by Inducing Inner Bulge Cell Apoptosis. Yang Q, et al. Stem Cells, 2022 Sep 26. PMID 35759955
  4. The forkhead box transcription factor FoxP4 regulates thermogenic programs in adipocytes. Perie L, et al. J Lipid Res, 2021. PMID 34384787, Free PMC Article
  5. Foxp4 is essential in maintenance of Purkinje cell dendritic arborization in the mouse cerebellum. Tam WY, et al. Neuroscience, 2011 Jan 13. PMID 20951773

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of Foxp4 Disrupts Cadherin-based Adhesion of Radial Glial Cells, Leading to Abnormal Differentiation and Migration of Cortical Neurons in Mice.
    Title: Inhibition of Foxp4 Disrupts Cadherin-based Adhesion of Radial Glial Cells, Leading to Abnormal Differentiation and Migration of Cortical Neurons in Mice.
  2. Foxp1 and Foxp4 Deletion Causes the Loss of Follicle Stem Cell Niche and Cyclic Hair Shedding by Inducing Inner Bulge Cell Apoptosis.
    Title: Foxp1 and Foxp4 Deletion Causes the Loss of Follicle Stem Cell Niche and Cyclic Hair Shedding by Inducing Inner Bulge Cell Apoptosis.
  3. The forkhead box transcription factor FoxP4 regulates thermogenic programs in adipocytes.
    Title: The forkhead box transcription factor FoxP4 regulates thermogenic programs in adipocytes.
  4. Combined loss of all three Foxp1/2/4 family members in the developing anterior foregut endoderm leads to a loss of lung endoderm lineage commitment and subsequent development. Foxp1/2/4 deficient lungs express high levels of transcriptional regulators not normally expressed in developing lung. Ectopic expression of these transcriptional regulators is accompanied by decreased expression of lung restricted transcription.
    Title: Foxp transcription factors suppress a non-pulmonary gene expression program to permit proper lung development.
  5. Collectively, these findings reveal an important role for the FOXP1, 2, and 4 proteins in governing postnatal alpha cell expansion and function.
    Title: The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice.
  6. Foxp1/2/4 may regulate Runx2 during endochondral ossification.
    Title: Foxp1/2/4 regulate endochondral ossification as a suppresser complex.
  7. Loss of Foxp1/4 in the developing lung and in postnatal secretory epithelium leads to ectopic activation of the goblet cell fate program, in part, through de-repression of the protein disulfide isomerase anterior gradient 2 (Agr2).
    Title: Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.
  8. the data of this study revealed a Foxp-based transcriptional mechanism that regulates the integrity and cytoarchitecture of neuroepithelial progenitors
    Title: Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS.
  9. Foxp4 is dispensable for the early Purkinje cell (PC) dendrite outgrowth but is essential for the maintenance of PC dendritic arborization and subsequent association with Bergmann glial fibers.
    Title: Foxp4 is essential in maintenance of Purkinje cell dendritic arborization in the mouse cerebellum.
  10. Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of interleukin-6.
    Title: Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of interleukin-6.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryonic foregut morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lung secretory cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of lung goblet cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of lung goblet cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
forkhead box protein P4
Names
fork head-related protein like A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110824.2 → NP_001104294.1  forkhead box protein P4 isoform 1

    See identical proteins and their annotated locations for NP_001104294.1

    Status: VALIDATED

    Source sequence(s)
    AC113536, AC164306
    Consensus CDS
    CCDS50137.1
    UniProtKB/TrEMBL
    A0A0R4J161, D3Z726
    Related
    ENSMUSP00000094916.3, ENSMUST00000097311.9
    Conserved Domains (3) summary
    smart00339
    Location:472 → 544
    FH; FORKHEAD
    COG5025
    Location:370 → 565
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:309 → 376
    FOXP-CC; FOXP coiled-coil domain

  2. NM_001110825.2 → NP_001104295.1  forkhead box protein P4 isoform 2

    See identical proteins and their annotated locations for NP_001104295.1

    Status: VALIDATED

    Source sequence(s)
    AC113536, AC164306
    Consensus CDS
    CCDS50136.1
    UniProtKB/TrEMBL
    A0A0R4J1I5, D3Z726
    Related
    ENSMUSP00000108887.2, ENSMUST00000113262.2
    Conserved Domains (2) summary
    pfam00250
    Location:460 → 539
    Forkhead; Forkhead domain
    pfam16159
    Location:309 → 376
    FOXP-CC; FOXP coiled-coil domain

  3. NM_001403969.1 → NP_001390898.1  forkhead box protein P4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113536, AC164306

  4. NM_001403970.1 → NP_001390899.1  forkhead box protein P4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113536, AC164306

  5. NM_028767.3 → NP_083043.2  forkhead box protein P4 isoform 3

    See identical proteins and their annotated locations for NP_083043.2

    Status: VALIDATED

    Source sequence(s)
    AC113536, AC164306
    Consensus CDS
    CCDS50135.1
    UniProtKB/TrEMBL
    D3Z726
    Related
    ENSMUSP00000108890.2, ENSMUST00000113265.8
    Conserved Domains (2) summary
    pfam00250
    Location:459 → 538
    Forkhead; Forkhead domain
    pfam16159
    Location:308 → 375
    FOXP-CC; FOXP coiled-coil domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    48178058..48235401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317686.2 → XP_017173175.1  forkhead box protein P4 isoform X1

    UniProtKB/TrEMBL
    D3Z726
    Conserved Domains (3) summary
    smart00339
    Location:479 → 551
    FH; FORKHEAD
    COG5025
    Location:375 → 572
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:309 → 376
    FOXP-CC; FOXP coiled-coil domain

  2. XM_030250107.1 → XP_030105967.1  forkhead box protein P4 isoform X3

    UniProtKB/TrEMBL
    A0A0R4J161, D3Z726
    Conserved Domains (3) summary
    smart00339
    Location:472 → 544
    FH; FORKHEAD
    COG5025
    Location:370 → 565
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:309 → 376
    FOXP-CC; FOXP coiled-coil domain

  3. XM_017317687.3 → XP_017173176.1  forkhead box protein P4 isoform X1

    UniProtKB/TrEMBL
    D3Z726
    Conserved Domains (3) summary
    smart00339
    Location:479 → 551
    FH; FORKHEAD
    COG5025
    Location:375 → 572
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:309 → 376
    FOXP-CC; FOXP coiled-coil domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBY0.1 GenPept UniProtKB/Swiss-Prot:Q9DBY0

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