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VCP valosin containing protein [ Homo sapiens (human) ]

Gene ID: 7415, updated on 28-Nov-2021

Summary

Official Symbol
VCPprovided by HGNC
Official Full Name
valosin containing proteinprovided by HGNC
Primary source
HGNC:HGNC:12666
See related
Ensembl:ENSG00000165280 MIM:601023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p97; TERA; CDC48; FTDALS6
Summary
This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in appendix (RPKM 60.7), thyroid (RPKM 56.9) and 25 other tissues See more
Orthologs
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Genomic context

See VCP in Genome Data Viewer
Location:
9p13.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (35056064..35072625, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35056061..35072622, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene chromosome 9 open reading frame 131 Neighboring gene RNA, 7SL, cytoplasmic 338, pseudogene Neighboring gene FA complementation group G Neighboring gene phosphatidylinositol glycan anchor biosynthesis class O

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with VCP; predicted interaction to be within the endoplasmic reticulum to Golgi transport PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with valosin containing protein (VCP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Vpu vpu A functional ER-associated degradation pathway is required for Vpu-induced tetherin degradation. P97 ATPase (VCP) knockdown partially impairs Vpu-mediated tetherin degradation PubMed
vpu The VCP-UFD1L-NPL4 complex is required for HIV-1 Vpu-induced CD4 degradation in the ER-associated degradation pathway. The ATPase activity of VCP and ubiquitin binding to UFD1L are important for CD4 degradation by Vpu PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: FANCG

Homology

Clone Names

  • MGC8560, MGC131997, MGC148092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP hydrolysis activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ATP hydrolysis activity TAS
Traceable Author Statement
more info
PubMed 
enables BAT3 complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables K48-linked polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
enables MHC class I protein binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables deubiquitinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-like protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-specific protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in ER-associated misfolded protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ER-associated misfolded protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ERAD pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in NADH metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in aggresome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to arsenite ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endoplasmic reticulum stress-induced pre-emptive quality control IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
involved_in endoplasmic reticulum unfolded protein response TAS
Traceable Author Statement
more info
PubMed 
involved_in endosome to lysosome transport via multivesicular body sorting pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of protein localization TAS
Traceable Author Statement
more info
PubMed 
involved_in flavin adenine dinucleotide catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interstrand cross-link repair ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle disassembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ATP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Lys63-specific deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of oxidative phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ubiquitin-specific protease activity IEA
Inferred from Electronic Annotation
more info
 
involved_in proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein-DNA covalent cross-linking repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of aerobic respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of protein localization to chromatin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synapse organization IEA
Inferred from Electronic Annotation
more info
 
involved_in retrograde protein transport, ER to cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retrograde protein transport, ER to cytosol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retrograde protein transport, ER to cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stress granule disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in translesion synthesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of ATPase complex IEA
Inferred from Electronic Annotation
more info
 
part_of Derlin-1 retrotranslocation complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of VCP-NPL4-UFD1 AAA ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of VCP-NPL4-UFD1 AAA ATPase complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of VCP-NPL4-UFD1 AAA ATPase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of VCP-NPL4-UFD1 AAA ATPase complex TAS
Traceable Author Statement
more info
PubMed 
part_of VCP-NSFL1C complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in azurophil granule lumen TAS
Traceable Author Statement
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transitional endoplasmic reticulum ATPase
Names
15S Mg(2+)-ATPase p97 subunit
TER ATPase
NP_001341856.1
NP_001341857.1
NP_009057.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007887.1 RefSeqGene

    Range
    5001..21675
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_657

mRNA and Protein(s)

  1. NM_001354927.2NP_001341856.1  transitional endoplasmic reticulum ATPase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL353795, BU689324
    Related
    ENSP00000392088.2, ENST00000448530.6
    Conserved Domains (1) summary
    TIGR01243
    Location:1719
    CDC48; AAA family ATPase, CDC48 subfamily
  2. NM_001354928.2NP_001341857.1  transitional endoplasmic reticulum ATPase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL353795, BU689324
    Related
    ENSP00000399456.2, ENST00000417448.2
    Conserved Domains (1) summary
    TIGR01243
    Location:1719
    CDC48; AAA family ATPase, CDC48 subfamily
  3. NM_007126.5NP_009057.1  transitional endoplasmic reticulum ATPase isoform 1

    See identical proteins and their annotated locations for NP_009057.1

    Status: REVIEWED

    Source sequence(s)
    BC007562, BC110913, BU689324, DA880782
    Consensus CDS
    CCDS6573.1
    UniProtKB/Swiss-Prot
    P55072
    UniProtKB/TrEMBL
    V9HW80
    Related
    ENSP00000351777.6, ENST00000358901.11
    Conserved Domains (1) summary
    TIGR01243
    Location:25764
    CDC48; AAA family ATPase, CDC48 subfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    35056064..35072625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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