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Gpcpd1 glycerophosphocholine phosphodiesterase 1 [ Mus musculus (house mouse) ]

Gene ID: 74182, updated on 8-Jul-2021

Summary

Official Symbol
Gpcpd1provided by MGI
Official Full Name
glycerophosphocholine phosphodiesterase 1provided by MGI
Primary source
MGI:MGI:104898
See related
Ensembl:ENSMUSG00000027346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pr; Gde5; Prei4; AU015213; mKIAA1434; 2310004G06Rik; 2310032D16Rik
Expression
Broad expression in cortex adult (RPKM 15.8), frontal lobe adult (RPKM 14.8) and 24 other tissues See more
Orthologs
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Genomic context

See Gpcpd1 in Genome Data Viewer
Location:
2 F2; 2
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (132371002..132420173, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132529082..132578248, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (132354819..132403984, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700026D11 gene Neighboring gene predicted gene 14095 Neighboring gene expressed sequence AU019990 Neighboring gene ribosomal protein L23A, pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables glycerophosphocholine phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glycerophosphocholine phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glycerophosphocholine phosphodiesterase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables glycerophosphodiester phosphodiesterase activity TAS
Traceable Author Statement
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables starch binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in glycerophospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
glycerophosphocholine phosphodiesterase GPCPD1
Names
glycerophosphocholine phosphodiesterase GDE1 homolog
glycerophosphodiester phosphodiesterase 5
preimplantation protein 4
putative glycerophosphocholine phosphodiesterase GPCPD1
putative glycerophosphodiester phosphodiesterase 5
NP_001036137.1
NP_001277979.1
NP_001277980.1
NP_001277981.1
NP_001342577.1
NP_001342578.1
NP_001342579.1
NP_001342580.1
NP_001342581.1
NP_081372.1
NP_083078.3
XP_006500339.1
XP_006500340.1
XP_006500342.1
XP_006500343.1
XP_017174782.1
XP_030107990.1
XP_030107991.1
XP_030107992.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042672.1NP_001036137.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 8. The resulting isoform (3) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 4.
    Source sequence(s)
    AK031658, AK141374, AL807386
    Conserved Domains (3) summary
    cd05814
    Location:4127
    CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
    cd08607
    Location:322613
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    pfam03009
    Location:326613
    GDPD; Glycerophosphoryl diester phosphodiesterase family
  2. NM_001291050.1NP_001277979.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 1

    See identical proteins and their annotated locations for NP_001277979.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks an in-frame exon compared to variant 8. The resulting isoform (1) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 4. Variants 1, 5, 6, 7, and 12 all encode the same isoform (1).
    Source sequence(s)
    AK031658, AW125284
    Consensus CDS
    CCDS71151.1
    UniProtKB/Swiss-Prot
    Q8C0L9
    Conserved Domains (1) summary
    cd08607
    Location:138430
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
  3. NM_001291051.1NP_001277980.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 1

    See identical proteins and their annotated locations for NP_001277980.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks an in-frame exon compared to variant 8. The resulting isoform (1) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 4. Variants 1, 5, 6, 7, and 12 all encode the same isoform (1).
    Source sequence(s)
    AK031658, AK163419, AW125284
    Consensus CDS
    CCDS71151.1
    UniProtKB/Swiss-Prot
    Q8C0L9
    Related
    ENSMUSP00000105763.2, ENSMUST00000110136.8
    Conserved Domains (1) summary
    cd08607
    Location:138430
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
  4. NM_001291052.1NP_001277981.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 1

    See identical proteins and their annotated locations for NP_001277981.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and lacks an in-frame exon compared to variant 8. The resulting isoform (1) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 4. Variants 1, 5, 6, 7, and 12 all encode the same isoform (1).
    Source sequence(s)
    AK031658, AL807386, AW125284
    Consensus CDS
    CCDS71151.1
    UniProtKB/Swiss-Prot
    Q8C0L9
    Conserved Domains (1) summary
    cd08607
    Location:138430
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
  5. NM_001355648.1NP_001342577.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and coding sequence and lacks an in-frame exon compared to variant 8. The resulting isoform (1) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 4. Variants 1, 5, 6, 7, and 12 all encode the same isoform (1).
    Source sequence(s)
    AL807386
    Consensus CDS
    CCDS71151.1
    Conserved Domains (1) summary
    cd08607
    Location:138430
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
  6. NM_001355649.1NP_001342578.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) represents the longest transcript and encodes the longest isoform (4). Variants 8 and 9 both encode isoform 4.
    Source sequence(s)
    AL807386
    Conserved Domains (2) summary
    cd05814
    Location:4127
    CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
    cd08607
    Location:322621
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
  7. NM_001355650.1NP_001342579.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 8. Variants 8 and 9 both encode the same isoform (4).
    Source sequence(s)
    AL807386
    Conserved Domains (2) summary
    cd05814
    Location:4127
    CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
    cd08607
    Location:322621
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
  8. NM_001355651.1NP_001342580.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) lacks an alternate in-frame exon compared to variant 8. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 4. Variants 2 and 10 both encode the same isoform (2).
    Source sequence(s)
    AL807386
    Consensus CDS
    CCDS38246.1
    Related
    ENSMUSP00000105769.2, ENSMUST00000110142.8
    Conserved Domains (2) summary
    cd05814
    Location:4127
    CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
    cd08607
    Location:322614
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
  9. NM_001355652.1NP_001342581.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and coding sequence compared to variant 8. The resulting isoform (5) is shorter at the N-terminus compared to isoform 4.
    Source sequence(s)
    AL807386
    Conserved Domains (1) summary
    cd08607
    Location:138437
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
  10. NM_027096.2NP_081372.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 1

    See identical proteins and their annotated locations for NP_081372.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence and lacks an in-frame exon compared to variant 8. The resulting isoform (1) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 4. Variants 1, 5, 6, 7, and 12 all encode the same isoform (1).
    Source sequence(s)
    AK031658, AK050318, AW125284, BC033408
    Consensus CDS
    CCDS71151.1
    UniProtKB/Swiss-Prot
    Q8C0L9
    Conserved Domains (1) summary
    cd08607
    Location:138430
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
  11. NM_028802.3NP_083078.3  glycerophosphocholine phosphodiesterase GPCPD1 isoform 2

    See identical proteins and their annotated locations for NP_083078.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 8. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 4. Variants 2 and 10 both encode the same isoform (2).
    Source sequence(s)
    AK030645, AK031658, AK050318, AW125284
    Consensus CDS
    CCDS38246.1
    UniProtKB/Swiss-Prot
    Q8C0L9
    Related
    ENSMUSP00000062221.6, ENSMUST00000060955.12
    Conserved Domains (2) summary
    cd05814
    Location:4127
    CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
    cd08607
    Location:322614
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    132371002..132420173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500276.5XP_006500339.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X1

    See identical proteins and their annotated locations for XP_006500339.1

    Conserved Domains (1) summary
    cd08607
    Location:138437
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
  2. XM_030252132.1XP_030107992.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X2

    Conserved Domains (1) summary
    cd08607
    Location:138430
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
  3. XM_030252130.1XP_030107990.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X1

    Conserved Domains (1) summary
    cd08607
    Location:138437
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
  4. XM_006500280.4XP_006500343.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X1

    See identical proteins and their annotated locations for XP_006500343.1

    Conserved Domains (1) summary
    cd08607
    Location:138437
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
  5. XM_006500279.4XP_006500342.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X1

    See identical proteins and their annotated locations for XP_006500342.1

    Conserved Domains (1) summary
    cd08607
    Location:138437
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
  6. XM_030252131.2XP_030107991.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X1

    Conserved Domains (1) summary
    cd08607
    Location:138437
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
  7. XM_006500277.5XP_006500340.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X1

    See identical proteins and their annotated locations for XP_006500340.1

    Conserved Domains (1) summary
    cd08607
    Location:138437
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
  8. XM_017319293.3XP_017174782.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X1

    Conserved Domains (1) summary
    cd08607
    Location:138437
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins

RNA

  1. XR_003953728.2 RNA Sequence

  2. XR_003953727.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001042671.1: Suppressed sequence

    Description
    NM_001042671.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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