P2ry13 purinergic receptor P2Y, G-protein coupled 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: P2ry13provided by MGI
Official Full Name: purinergic receptor P2Y, G-protein coupled 13provided by MGI
Primary source: MGI:MGI:1921441
See related: Ensembl:ENSMUSG00000036362 AllianceGenome:MGI:1921441
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GPCR1; GPR94; Gpr86; P2Y13; SP174; P2yr13; 2010001L06Rik
Summary: Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Acts upstream of or within cellular response to organic cyclic compound. Located in endoplasmic reticulum. Is expressed in immune system; intestine; male reproductive gland or organ; and skin. Orthologous to human P2RY13 (purinergic receptor P2Y13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 7.3), cortex adult (RPKM 4.6) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 D; 3 29.01 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (59115313..59118303, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (59207892..59210882, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting the P2Y13 Receptor Suppresses IL-33 and HMGB1 Release and Ameliorates Experimental Asthma.
Title: Targeting the P2Y(13) Receptor Suppresses IL-33 and HMGB1 Release and Ameliorates Experimental Asthma.
Nucleotide transmitters ATP and ADP mediate intercellular calcium wave communication via P2Y12/P2Y13 receptors among BV-2 microglia.
Title: Nucleotide transmitters ATP and ADP mediate intercellular calcium wave communication via P2Y12/13 receptors among BV-2 microglia.
Conclude that, at motor nerve terminals, the Gi/o protein-coupled P2Y receptors implicated in presynaptic inhibition of spontaneous and evoked acetylcholine release are of the subtype P2Y13. This study provides new insights into the types of purinergic receptors that contribute to the fine-tuning of cholinergic transmission at mammalian neuromuscular junction.
Title: P2Y13 receptors mediate presynaptic inhibition of acetylcholine release induced by adenine nucleotides at the mouse neuromuscular junction.
The P2Y13 receptor protects against atherosclerosis, primarily through its role in hepatobiliary reverse cholesterol transport
Title: Increased atherosclerosis in P2Y13/apolipoprotein E double-knockout mice: contribution of P2Y13 to reverse cholesterol transport.
P2Y13 receptor activation is crucial in mediating the high-fat-diet and palmitic acid-induced myenteric neuronal loss.
Title: The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss.
Up-regulation of HDL-cholesterol metabolism via activation of the P2Y13R using agonists could promote reverse cholesterol transport and promote inhibition of atherosclerosis progression in mice.
Title: P2Y13 receptor regulates HDL metabolism and atherosclerosis in vivo.
Findings indicate that the P2Y13 R plays an important role in the balance of osteoblast and adipocyte terminal differentiation of bone marrow progenitors.
Title: Role of the P2Y13 receptor in the differentiation of bone marrow stromal cells into osteoblasts and adipocytes.
P2Y13 receptor regulates phosphate metabolism and FGF-23 secretion with effects on skeletal development
Title: The P2Y13 receptor regulates phosphate metabolism and FGF-23 secretion with effects on skeletal development.
The regulation of P2Y13-R expression and provided evidence that P2Y13-R is tightly regulated by constitutive ubiquitination in the ER, and subsequent proteasome degradation.
Title: Role of the ubiquitin-proteasome system in the regulation of P2Y13 receptor expression: impact on hepatic HDL uptake.
The P2Y13 receptor regulates extracellular ATP metabolism and the osteogenic response to mechanical loading.
Title: The P2Y13 receptor regulates extracellular ATP metabolism and the osteogenic response to mechanical loading.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled purinergic nucleotide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled purinergic nucleotide receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of adenylate cyclase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: P2Y purinoceptor 13

Names: G protein-coupled receptor 68; G protein-coupled receptor 86; Vpurinergic receptor P2Y, G-protein coupled 13; purinergic receptor P2Y13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.