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VEGFA vascular endothelial growth factor A [ Homo sapiens (human) ]

Gene ID: 7422, updated on 28-Nov-2021

Summary

Official Symbol
VEGFAprovided by HGNC
Official Full Name
vascular endothelial growth factor Aprovided by HGNC
Primary source
HGNC:HGNC:12680
See related
Ensembl:ENSG00000112715 MIM:192240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VPF; VEGF; MVCD1
Summary
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. The levels of VEGF are increased during infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus promoting inflammation by facilitating recruitment of inflammatory cells, and by increasing the level of angiopoietin II (Ang II), one of two products of the SARS-CoV-2 binding target, angiotensin-converting enzyme 2 (ACE2). In turn, Ang II facilitates the elevation of VEGF, thus forming a vicious cycle in the release of inflammatory cytokines. [provided by RefSeq, Jun 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Expression
Broad expression in thyroid (RPKM 146.9), prostate (RPKM 69.5) and 21 other tissues See more
Orthologs
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Genomic context

See VEGFA in Genome Data Viewer
Location:
6p21.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (43770209..43786487)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43737946..43754224)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA polymerase I and III subunit C Neighboring gene exosome component 8 pseudogene Neighboring gene radial spoke head component 9 Neighboring gene mitochondrial ribosomal protein S18A Neighboring gene Sharpr-MPRA regulatory region 8365 Neighboring gene uncharacterized LOC105375070 Neighboring gene uncharacterized LOC107986598 Neighboring gene uncharacterized LOC105375069

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.
GeneReviews: Not available
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
GeneReviews: Not available
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
GeneReviews: Not available
Discovery and refinement of loci associated with lipid levels.
GeneReviews: Not available
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
GeneReviews: Not available
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
GeneReviews: Not available
Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels.
GeneReviews: Not available
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
GeneReviews: Not available
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
GeneReviews: Not available
Microvascular complications of diabetes 1
MedGen: C2676832 OMIM: 603933 GeneReviews: Not available
Compare labs
New loci associated with kidney function and chronic kidney disease.
GeneReviews: Not available
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
GeneReviews: Not available
Seven new loci associated with age-related macular degeneration.
GeneReviews: Not available
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
GeneReviews: Not available

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2012-04-25)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2012-04-25)

ClinGen Genome Curation PagePubMed

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 modulates expression of the cytokines IL1beta, IL3, IL6, IL10, IL13, IL15, IFNbeta2A, IFNgamma, IFNomega, TNFalpha, VEGF, VEGF B, and LIF in PBMCs and MDMs PubMed
Nef nef HIV-1 Nef synergizes with IL-6 to enhance vascular tube formation, cell proliferation, VEGF expression, and phosphorylated AKT activation in human umbilical vein endothelial cells PubMed
nef HIV-1 Nef increases expression of both VEGF and its transcriptional regulator, hypoxia-inducible factor 2alpha (HIF-2alpha), in a Src kinase-and Stat3-dependent manner PubMed
Tat tat HIV-1 Tat increases permeability of human glomerular endothelial cells by activating Rho-A, pMLC, and c-Src pathways, which involves VEGF-A or FGF-2. PubMed
tat VEGF can compete with HIV-1 Tat chemotactic activity in Kaposi's sarcoma (KS) cells, indicating Tat may cooperate with VEGF in activation of VEGFR-2 on KS precursor spindle and endothelial cells and contribute to the aggressiveness of AIDS-KS lesions PubMed
tat HIV-1 Tat upregulates VEGFA (VEGF) expression in HUVEC and EA.hy926 cells PubMed
tat HIV-1 Tat upregulates members of the PDGF/VEGF growth factor family (PDGFA, VEGFA,VEGFB, VEGFC) in mammary epithelial cells PubMed
tat HIV-1 Tat enhances vIL-6-induced angiogenesis and tumorigenesis of fibroblasts and human endothelial cells, which correlates with upregulation of CD31, CD34, SMA, VEGF, b-FGF, and cyclin D1 expression PubMed
tat HIV-1 Tat enhances Kaposi's sarcoma-associated herpesvirus vIL-6-induced cell proliferation, cellular transformation, vascular tube formation, and VEGF production in tumor cells PubMed
tat HIV-1 Tat inhibits the differentiation of mesenchymal stem cells (MSCs) to endothelial cells by downregulating the expression of VEGF-induced endothelial markers such as Flt-1, KDR and vWF PubMed
tat The chemokine like region of HIV-1 Tat (amino acids 24-51) induces the release of angiogenic factors, including vascular endothelial growth factor (VEGF), an effect linked to Tat induced angiogenesis PubMed
Vpu vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to upregulate expression of profibrogenic markers COL-1, PCT, SMA-1, VEGF, and MMP2, which is inhibited by MIF treatment PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC70609

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chemoattractant activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemoattractant activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables extracellular matrix binding IC
Inferred by Curator
more info
PubMed 
enables fibronectin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heparin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables platelet-derived growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables receptor ligand activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables receptor ligand activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables vascular endothelial growth factor receptor 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vascular endothelial growth factor receptor 1 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables vascular endothelial growth factor receptor 2 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vascular endothelial growth factor receptor 2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables vascular endothelial growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vascular endothelial growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in VEGF-activated neuropilin signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in activation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in artery morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in camera-type eye morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cardiac muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cardiac vascular smooth muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular stress response to acid chemical IDA
Inferred from Direct Assay
more info
PubMed 
involved_in commissural neuron axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in coronary artery morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in coronary vein morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dopaminergic neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endothelial cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in eye photoreceptor cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heart morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in in utero embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in induction of positive chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in induction of positive chemotaxis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in kidney development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lactation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lung development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lymph vessel morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in macrophage differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mammary gland alveolus development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mesoderm development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in monocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in motor neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of adherens junction organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of blood-brain barrier permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell-cell adhesion mediated by cadherin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of establishment of endothelial barrier IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in outflow tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ovarian follicle development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of CREB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of axon extension involved in axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of branching involved in ureteric bud morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration involved in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cellular component movement IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of leukocyte migration TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of mast cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of neuroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of p38MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase C signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase D signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of retinal ganglion cell axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription from RNA polymerase II promoter in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of trophoblast cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in positive regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular permeability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in post-embryonic camera-type eye development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in primitive erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of nitric oxide mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of retinal ganglion cell axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in surfactant homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in tube formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vascular endothelial growth factor receptor-2 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular endothelial growth factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vascular endothelial growth factor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasculogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular matrix NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in platelet alpha granule lumen TAS
Traceable Author Statement
more info
 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vascular endothelial growth factor A
Names
vascular endothelial growth factor A121
vascular endothelial growth factor A165
vascular permeability factor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008732.1 RefSeqGene

    Range
    4996..21272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025366.3NP_001020537.2  vascular endothelial growth factor A isoform a

    Status: REVIEWED

    Source sequence(s)
    AF024710, BF700556, BM661679, BU153227, CN256173, DA237741, S85192
    Consensus CDS
    CCDS34457.1
    UniProtKB/Swiss-Prot
    P15692
    UniProtKB/TrEMBL
    A0A087WUD8
    Related
    ENSP00000361125.5, ENST00000372055.9
    Conserved Domains (2) summary
    smart00141
    Location:230312
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:364412
    VEGF_C; VEGF heparin-binding domain
  2. NM_001025367.3NP_001020538.2  vascular endothelial growth factor A isoform c

    Status: REVIEWED

    Source sequence(s)
    AF024710, AJ010438, BF700556, BM661679, BU153227, CN256173, DA237741
    Consensus CDS
    CCDS47433.1
    UniProtKB/Swiss-Prot
    P15692
    Related
    ENSP00000389864.4, ENST00000413642.8
    Conserved Domains (2) summary
    smart00141
    Location:230312
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:341389
    VEGF_C; VEGF heparin-binding domain
  3. NM_001025368.3NP_001020539.2  vascular endothelial growth factor A isoform d

    Status: REVIEWED

    Source sequence(s)
    AB021221, AF024710, BF700556, BM661679, BU153227, CN256173, DA237741
    Consensus CDS
    CCDS34458.1
    UniProtKB/Swiss-Prot
    P15692
    UniProtKB/TrEMBL
    A0A087X0B2
    Related
    ENSP00000361137.4, ENST00000372067.8
    Conserved Domains (2) summary
    smart00141
    Location:230312
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:318371
    VEGF_C; VEGF heparin-binding domain
  4. NM_001025369.3NP_001020540.2  vascular endothelial growth factor A isoform e

    See identical proteins and their annotated locations for NP_001020540.2

    Status: REVIEWED

    Source sequence(s)
    AF024710, AF091352, BF700556, BM661679, BU153227, CN256173, DA237741
    Consensus CDS
    CCDS47435.1
    UniProtKB/Swiss-Prot
    P15692
    Related
    ENSP00000388663.3, ENST00000417285.7
    Conserved Domains (2) summary
    smart00141
    Location:230312
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:318353
    VEGF_C; VEGF heparin-binding domain
  5. NM_001025370.3NP_001020541.2  vascular endothelial growth factor A isoform f

    Status: REVIEWED

    Source sequence(s)
    AF024710, AF214570, BF700556, BM661679, BU153227, CN256173, DA237741
    Consensus CDS
    CCDS47434.1
    UniProtKB/Swiss-Prot
    P15692
    UniProtKB/TrEMBL
    A0A087WTP4
    Related
    ENSP00000361134.5, ENST00000372064.9
    Conserved Domains (1) summary
    smart00141
    Location:230312
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  6. NM_001033756.3NP_001028928.1  vascular endothelial growth factor A isoform g

    See identical proteins and their annotated locations for NP_001028928.1

    Status: REVIEWED

    Source sequence(s)
    AF024710, AF430806, BF700556, BM661679, BU153227, CN256173, DA237741
    Consensus CDS
    CCDS47432.1
    UniProtKB/Swiss-Prot
    P15692
    UniProtKB/TrEMBL
    A0A087X1L1
    Related
    ENSP00000421561.2, ENST00000482630.7
    Conserved Domains (2) summary
    smart00141
    Location:230312
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:318365
    VEGF_C; VEGF heparin-binding domain
  7. NM_001171622.2NP_001165093.1  vascular endothelial growth factor A isoform h

    Status: REVIEWED

    Source sequence(s)
    AF024710, BF700556, BM661679, BU153227, CN256173, DA237741, DQ229900
    Consensus CDS
    CCDS55007.1
    UniProtKB/Swiss-Prot
    P15692
    Related
    ENSP00000317598.7, ENST00000324450.11
    Conserved Domains (1) summary
    smart00141
    Location:230311
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  8. NM_001171623.2NP_001165094.1  vascular endothelial growth factor A isoform i precursor

    See identical proteins and their annotated locations for NP_001165094.1

    Status: REVIEWED

    Source sequence(s)
    AL136131
    Consensus CDS
    CCDS55010.1
    UniProtKB/Swiss-Prot
    P15692
    UniProtKB/TrEMBL
    A0A024RD33
    Related
    ENSP00000430479.1, ENST00000523873.5
    Conserved Domains (2) summary
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:184232
    VEGF_C; VEGF heparin-binding domain
  9. NM_001171624.2NP_001165095.1  vascular endothelial growth factor A isoform j precursor

    See identical proteins and their annotated locations for NP_001165095.1

    Status: REVIEWED

    Source sequence(s)
    AL136131
    Consensus CDS
    CCDS55009.1
    UniProtKB/Swiss-Prot
    P15692
    UniProtKB/TrEMBL
    A0A024RD37
    Related
    ENSP00000428321.1, ENST00000520948.5
    Conserved Domains (2) summary
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:167215
    VEGF_C; VEGF heparin-binding domain
  10. NM_001171625.2NP_001165096.1  vascular endothelial growth factor A isoform k precursor

    See identical proteins and their annotated locations for NP_001165096.1

    Status: REVIEWED

    Source sequence(s)
    AL136131
    Consensus CDS
    CCDS55008.1
    UniProtKB/Swiss-Prot
    P15692
    Related
    ENSP00000430829.1, ENST00000518689.5
    Conserved Domains (2) summary
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:161209
    VEGF_C; VEGF heparin-binding domain
  11. NM_001171626.2NP_001165097.1  vascular endothelial growth factor A isoform VEGF-A precursor

    See identical proteins and their annotated locations for NP_001165097.1

    Status: REVIEWED

    Source sequence(s)
    AL136131
    Consensus CDS
    CCDS55012.1
    UniProtKB/Swiss-Prot
    P15692
    UniProtKB/TrEMBL
    A0A0Y0IMM4
    Related
    ENSP00000429643.1, ENST00000523950.5
    Conserved Domains (2) summary
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:143191
    VEGF_C; VEGF heparin-binding domain
  12. NM_001171627.2NP_001165098.1  vascular endothelial growth factor A isoform m precursor

    See identical proteins and their annotated locations for NP_001165098.1

    Status: REVIEWED

    Source sequence(s)
    AL136131
    Consensus CDS
    CCDS55011.1
    UniProtKB/Swiss-Prot
    P15692
    Related
    ENSP00000429008.1, ENST00000523125.5
    Conserved Domains (2) summary
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:143173
    VEGF_C; VEGF heparin-binding domain
  13. NM_001171628.2NP_001165099.1  vascular endothelial growth factor A isoform n precursor

    See identical proteins and their annotated locations for NP_001165099.1

    Status: REVIEWED

    Source sequence(s)
    AL136131
    Consensus CDS
    CCDS55014.1
    UniProtKB/Swiss-Prot
    P15692
    Related
    ENSP00000361148.4, ENST00000372077.8
    Conserved Domains (1) summary
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  14. NM_001171629.2NP_001165100.1  vascular endothelial growth factor A isoform o precursor

    See identical proteins and their annotated locations for NP_001165100.1

    Status: REVIEWED

    Source sequence(s)
    AL136131
    Consensus CDS
    CCDS55013.1
    UniProtKB/Swiss-Prot
    P15692
    Related
    ENSP00000430002.1, ENST00000518824.5
    Conserved Domains (2) summary
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:143185
    VEGF_C; VEGF heparin-binding domain
  15. NM_001171630.2NP_001165101.1  vascular endothelial growth factor A isoform p precursor

    See identical proteins and their annotated locations for NP_001165101.1

    Status: REVIEWED

    Source sequence(s)
    AL136131
    Consensus CDS
    CCDS55015.1
    UniProtKB/Swiss-Prot
    P15692
    Related
    ENSP00000409911.2, ENST00000457104.6
    Conserved Domains (1) summary
    smart00141
    Location:50131
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  16. NM_001204384.2NP_001191313.1  vascular endothelial growth factor A isoform q precursor

    See identical proteins and their annotated locations for NP_001191313.1

    Status: REVIEWED

    Source sequence(s)
    AL136131
    UniProtKB/Swiss-Prot
    P15692
    Conserved Domains (1) summary
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  17. NM_001204385.2NP_001191314.1  vascular endothelial growth factor A isoform r

    Status: REVIEWED

    Source sequence(s)
    AL136131, BC065522, M27281
    UniProtKB/Swiss-Prot
    P15692
    Related
    ENSP00000430594.1, ENST00000519767.5
    Conserved Domains (1) summary
    smart00141
    Location:230312
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  18. NM_001287044.2NP_001273973.1  vascular endothelial growth factor A isoform s

    See identical proteins and their annotated locations for NP_001273973.1

    Status: REVIEWED

    Source sequence(s)
    AL136131, BC058855, BC065522, BX442364, HY066915
    Consensus CDS
    CCDS69125.1
    UniProtKB/Swiss-Prot
    P15692
    UniProtKB/TrEMBL
    A2A2V4
    Related
    ENSP00000230480.6, ENST00000230480.10
    Conserved Domains (2) summary
    smart00141
    Location:22104
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:115163
    VEGF_C; VEGF heparin-binding domain
  19. NM_001317010.1NP_001303939.1  vascular endothelial growth factor A isoform VEGF-Ax precursor

    Status: REVIEWED

    Source sequence(s)
    AB021221, AF024710, BF700556, BM661679, BU153227, CN256173, DA237741
    UniProtKB/Swiss-Prot
    P15692
    Conserved Domains (2) summary
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:140191
    VEGF_C; VEGF heparin-binding domain
  20. NM_003376.6NP_003367.4  vascular endothelial growth factor A isoform b

    See identical proteins and their annotated locations for NP_003367.4

    Status: REVIEWED

    Source sequence(s)
    AF024710, BF700556, BM661679, BU153227, CN256173, DA237741, M27281
    Consensus CDS
    CCDS4907.2
    UniProtKB/Swiss-Prot
    P15692
    Related
    ENSP00000388465.3, ENST00000425836.7
    Conserved Domains (2) summary
    smart00141
    Location:230312
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:347395
    VEGF_C; VEGF heparin-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    43770209..43786487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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