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Matcap1 microtubule associated tyrosine carboxypeptidase 1 [ Mus musculus (house mouse) ]

Gene ID: 74356, updated on 5-Mar-2024

Summary

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Official Symbol
Matcap1provided by MGI
Official Full Name
microtubule associated tyrosine carboxypeptidase 1provided by MGI
Primary source
MGI:MGI:1921606
See related
Ensembl:ENSMUSG00000014837 AllianceGenome:MGI:1921606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MATCAP; Kiaa0895l; 4931428F04Rik
Summary
Orthologous to human KIAA0895L (KIAA0895 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 28.7), whole brain E14.5 (RPKM 27.0) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 D3; 8 53.04 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106007041..106016160, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105280409..105289528, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8260 Neighboring gene F-box and leucine-rich repeat protein 8 Neighboring gene heat shock transcription factor 4 Neighboring gene nucleolar protein 3 (apoptosis repressor with CARD domain) Neighboring gene STARR-positive B cell enhancer ABC_E1768 Neighboring gene STARR-positive B cell enhancer ABC_E3797 Neighboring gene uncharacterized LOC102636360 Neighboring gene exocyst complex component 3-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:107822735-107822970 Neighboring gene E2F transcription factor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Posttranslational modification of microtubules by the MATCAP detyrosinase. Landskron L, et al. Science, 2022 May 20. PMID 35482892
  2. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Keegan CE, et al. Hum Mol Genet, 2005 Jan 1. PMID 15537664
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables tubulin-tyrosine carboxypeptidase ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
microtubule-associated tyrosine carboxypeptidase
NP_001159866.1
NP_083164.1
XP_006531496.1
XP_017168480.1
XP_036010229.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166394.1 → NP_001159866.1  microtubule-associated tyrosine carboxypeptidase

    See identical proteins and their annotated locations for NP_001159866.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK016481, BC043046, CJ064766
    Consensus CDS
    CCDS22596.1
    UniProtKB/Swiss-Prot
    Q810A5, Q9D4J6
    Related
    ENSMUSP00000014981.7, ENSMUST00000014981.8
    Conserved Domains (1) summary
    cl06858
    Location:233 → 424
    DUF1704; Domain of unknown function (DUF1704)

  2. NM_028888.2 → NP_083164.1  microtubule-associated tyrosine carboxypeptidase

    See identical proteins and their annotated locations for NP_083164.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC043046, CJ064766
    Consensus CDS
    CCDS22596.1
    UniProtKB/Swiss-Prot
    Q810A5, Q9D4J6
    Related
    ENSMUSP00000128530.2, ENSMUST00000171788.8
    Conserved Domains (1) summary
    cl06858
    Location:233 → 424
    DUF1704; Domain of unknown function (DUF1704)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106007041..106016160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154336.1 → XP_036010229.1  microtubule-associated tyrosine carboxypeptidase isoform X1

    Conserved Domains (1) summary
    cl06858
    Location:263 → 454
    DUF1704; Domain of unknown function (DUF1704)

  2. XM_017312991.3 → XP_017168480.1  microtubule-associated tyrosine carboxypeptidase isoform X1

    Conserved Domains (1) summary
    cl06858
    Location:263 → 454
    DUF1704; Domain of unknown function (DUF1704)

  3. XM_006531433.4 → XP_006531496.1  microtubule-associated tyrosine carboxypeptidase isoform X2

    See identical proteins and their annotated locations for XP_006531496.1

    UniProtKB/Swiss-Prot
    Q810A5, Q9D4J6
    Related
    ENSMUSP00000148836.2, ENSMUST00000212219.2
    Conserved Domains (1) summary
    cl06858
    Location:233 → 424
    DUF1704; Domain of unknown function (DUF1704)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q810A5.1 GenPept UniProtKB/Swiss-Prot:Q810A5

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