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Gsdmc4 gasdermin C4 [ Mus musculus (house mouse) ]

Gene ID: 74548, updated on 8-Feb-2024

Summary

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Official Symbol
Gsdmc4provided by MGI
Official Full Name
gasdermin C4provided by MGI
Primary source
MGI:MGI:1921798
See related
Ensembl:ENSMUSG00000055748 AllianceGenome:MGI:1921798
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GsdmC-2; 9030605I04Rik
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Predicted to be involved in defense response to bacterium and pyroptosis. Predicted to act upstream of or within programmed cell death. Predicted to be located in cytoplasm. Is expressed in genitourinary system and gut. Orthologous to human GSDMC (gasdermin C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 65.4), large intestine adult (RPKM 35.7) and 2 other tissues See more
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Genomic context

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Location:
15 D1; 15 28.07 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (63762989..63784168, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (63891140..63912319, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene gasdermin C3 Neighboring gene gasdermin C-like 2 Neighboring gene gasdermin C-like, pseudogene Neighboring gene CYFIP related Rac1 interactor B Neighboring gene STARR-seq mESC enhancer starr_38847 Neighboring gene predicted gene, 25628

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Tamura M, et al. Genomics, 2007 May. PMID 17350798
  2. Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression. Grassmeyer J, et al. Dev Biol, 2017 Apr 1. PMID 28215940, Free PMC Article
  3. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
  4. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables wide pore channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within programmed cell death IEA
Inferred from Electronic Annotation
more info
  
involved_in pyroptosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyroptosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
gasdermin-C4
Names
gasderminC-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028992.1 → NP_083268.1  gasdermin-C4

    See identical proteins and their annotated locations for NP_083268.1

    Status: VALIDATED

    Source sequence(s)
    AK018537, AK163061, BY460367
    Consensus CDS
    CCDS49617.1
    UniProtKB/Swiss-Prot
    E9QKJ0, Q3TR54, Q9D326
    UniProtKB/TrEMBL
    A0A679B0N4
    Related
    ENSMUSP00000140269.2, ENSMUST00000188108.7
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 233
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    63762989..63784168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521502.4 → XP_006521565.1  gasdermin-C4 isoform X1

    See identical proteins and their annotated locations for XP_006521565.1

    UniProtKB/Swiss-Prot
    E9QKJ0, Q3TR54, Q9D326
    UniProtKB/TrEMBL
    A0A679B0N4
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 233
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

  2. XM_011245757.3 → XP_011244059.1  gasdermin-C4 isoform X2

    Conserved Domains (2) summary
    pfam04598
    Location:4 → 233
    Gasdermin; Gasdermin family
    pfam17708
    Location:265 → 432
    Gasdermin_C; Gasdermin PUB domain

  3. XM_011245754.3 → XP_011244056.1  gasdermin-C4 isoform X1

    See identical proteins and their annotated locations for XP_011244056.1

    UniProtKB/Swiss-Prot
    E9QKJ0, Q3TR54, Q9D326
    UniProtKB/TrEMBL
    A0A679B0N4
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 233
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

  4. XM_011245755.4 → XP_011244057.1  gasdermin-C4 isoform X1

    See identical proteins and their annotated locations for XP_011244057.1

    UniProtKB/Swiss-Prot
    E9QKJ0, Q3TR54, Q9D326
    UniProtKB/TrEMBL
    A0A679B0N4
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 233
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain

  5. XM_011245756.3 → XP_011244058.1  gasdermin-C4 isoform X1

    See identical proteins and their annotated locations for XP_011244058.1

    UniProtKB/Swiss-Prot
    E9QKJ0, Q3TR54, Q9D326
    UniProtKB/TrEMBL
    A0A679B0N4
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 233
    Gasdermin; Gasdermin family
    pfam17708
    Location:272 → 441
    Gasdermin_C; Gasdermin PUB domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TR54.2 GenPept UniProtKB/Swiss-Prot:Q3TR54

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