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Cds1 CDP-diacylglycerol synthase 1 [ Mus musculus (house mouse) ]

Gene ID: 74596, updated on 5-Mar-2024

Summary

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Official Symbol
Cds1provided by MGI
Official Full Name
CDP-diacylglycerol synthase 1provided by MGI
Primary source
MGI:MGI:1921846
See related
Ensembl:ENSMUSG00000029330 AllianceGenome:MGI:1921846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4833409J18Rik
Summary
Predicted to enable phosphatidate cytidylyltransferase activity. Involved in lipid droplet formation and positive regulation of fat cell differentiation. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human CDS1 (CDP-diacylglycerol synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 48.2), duodenum adult (RPKM 46.8) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 E5; 5 48.93 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (101913001..101971724)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (101765093..101823858)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9430085M18 gene Neighboring gene STARR-seq mESC enhancer starr_13743 Neighboring gene predicted gene, 42134 Neighboring gene STARR-seq mESC enhancer starr_13745 Neighboring gene STARR-positive B cell enhancer mm9_chr5:102222626-102222927 Neighboring gene STARR-seq mESC enhancer starr_13749 Neighboring gene STARR-seq mESC enhancer starr_13750 Neighboring gene STARR-seq mESC enhancer starr_13751 Neighboring gene WD repeat and FYVE domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_13753 Neighboring gene STARR-seq mESC enhancer starr_13754 Neighboring gene predicted gene, 42135 Neighboring gene STARR-seq mESC enhancer starr_13755 Neighboring gene STARR-seq mESC enhancer starr_13758 Neighboring gene predicted gene, 42136

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2. Inglis-Broadgate SL, et al. Gene, 2005 Aug 15. PMID 16023307
  2. CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development. Qi Y, et al. J Lipid Res, 2016 May. PMID 26946540, Free PMC Article
  3. The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. Lykidis A, et al. J Biol Chem, 1997 Dec 26. PMID 9407135
  4. Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene. Volta M, et al. Genomics, 1999 Jan 1. PMID 9889000
  5. FoxP1 orchestration of ASD-relevant signaling pathways in the striatum. Araujo DJ, et al. Genes Dev, 2015 Oct 15. PMID 26494785, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cds1 showed a very restricted expression pattern and was mapped to chromosome 5E3.
    Title: Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidate cytidylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within CDP-diacylglycerol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid droplet formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid droplet formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphatidate cytidylyltransferase 1
Names
CDP-DAG synthase 1
CDP-DG synthase 1
CDP-diglyceride pyrophosphorylase 1
CDP-diglyceride synthase 1
CDS 1
CTP:phosphatidate cytidylyltransferase 1
NP_001404788.1
NP_001404789.1
NP_775546.2
XP_006535326.1
XP_006535327.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417859.1 → NP_001404788.1  phosphatidate cytidylyltransferase 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC121983, AC171108, AC172745

  2. NM_001417860.1 → NP_001404789.1  phosphatidate cytidylyltransferase 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC121983, AC172745

  3. NM_173370.4 → NP_775546.2  phosphatidate cytidylyltransferase 1 isoform a

    See identical proteins and their annotated locations for NP_775546.2

    Status: VALIDATED

    Source sequence(s)
    AC121983, AC171108, AC172745
    Consensus CDS
    CCDS19472.1
    UniProtKB/Swiss-Prot
    P98191, Q8CGZ1
    Related
    ENSMUSP00000031273.9, ENSMUST00000031273.9
    Conserved Domains (1) summary
    cl21502
    Location:123 → 457
    CTP_transf_1; Cytidylyltransferase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    101913001..101971724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535264.3 → XP_006535327.1  phosphatidate cytidylyltransferase 1 isoform X2

    Conserved Domains (1) summary
    cl21502
    Location:123 → 377
    CTP_transf_1; Cytidylyltransferase family

  2. XM_006535263.4 → XP_006535326.1  phosphatidate cytidylyltransferase 1 isoform X1

    Conserved Domains (1) summary
    cl21502
    Location:123 → 400
    CTP_transf_1; Cytidylyltransferase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P98191.2 GenPept UniProtKB/Swiss-Prot:P98191

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