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Hhatl hedgehog acyltransferase-like [ Mus musculus (house mouse) ]

Gene ID: 74770, updated on 5-Jan-2022

Summary

Official Symbol
Hhatlprovided by MGI
Official Full Name
hedgehog acyltransferase-likeprovided by MGI
Primary source
MGI:MGI:1922020
See related
Ensembl:ENSMUSG00000032523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gup1; Mg56; 1110011D13Rik
Summary
Predicted to enable acyltransferase activity. Involved in negative regulation of N-terminal protein palmitoylation. Located in endoplasmic reticulum. Orthologous to human HHATL (hedgehog acyltransferase like). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in heart adult (RPKM 20.6), mammary gland adult (RPKM 4.7) and 6 other tissues See more
Orthologs
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Genomic context

See Hhatl in Genome Data Viewer
Location:
9; 9 F4
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121613082..121626604, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (121784016..121792507, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (121693134..121701625, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E530011L22 gene Neighboring gene zinc finger protein 651 Neighboring gene kelch-like 40 Neighboring gene coiled-coil domain containing 13 Neighboring gene predicted gene, 51698 Neighboring gene HIG1 domain family, member 1A Neighboring gene predicted gene, 47112

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein-cysteine N-palmitoyltransferase HHAT-like protein
Names
Mitsugumin 56
glycerol uptake/transporter homolog
hedgehog acyltransferase-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029095.2NP_083371.2  protein-cysteine N-palmitoyltransferase HHAT-like protein

    See identical proteins and their annotated locations for NP_083371.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AC165080, AK003605, BY232310, BY290483, BY703867
    Consensus CDS
    CCDS23638.1
    UniProtKB/Swiss-Prot
    Q9D1G3
    Related
    ENSMUSP00000035110.5, ENSMUST00000035110.11
    Conserved Domains (1) summary
    cl00738
    Location:139449
    MBOAT; membrane-bound O-acyltransferase family

RNA

  1. NR_027967.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC165080, AK157924

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    121613082..121626604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155362.1XP_036011255.1  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X2

    Conserved Domains (1) summary
    cl00738
    Location:86235
    MBOAT; membrane-bound O-acyltransferase family
  2. XM_030244689.2XP_030100549.1  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X1

    Conserved Domains (1) summary
    cl00738
    Location:139449
    MBOAT; membrane-bound O-acyltransferase family
  3. XM_006512380.5XP_006512443.1  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X1

    See identical proteins and their annotated locations for XP_006512443.1

    UniProtKB/Swiss-Prot
    Q9D1G3
    Conserved Domains (1) summary
    cl00738
    Location:139449
    MBOAT; membrane-bound O-acyltransferase family
  4. XM_006512379.4XP_006512442.1  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X1

    See identical proteins and their annotated locations for XP_006512442.1

    UniProtKB/Swiss-Prot
    Q9D1G3
    Conserved Domains (1) summary
    cl00738
    Location:139449
    MBOAT; membrane-bound O-acyltransferase family
  5. XM_006512381.4XP_006512444.1  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X1

    See identical proteins and their annotated locations for XP_006512444.1

    UniProtKB/Swiss-Prot
    Q9D1G3
    Related
    ENSMUSP00000131971.2, ENSMUST00000163981.3
    Conserved Domains (1) summary
    cl00738
    Location:139449
    MBOAT; membrane-bound O-acyltransferase family
  6. XM_011243053.2XP_011241355.1  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X2

    Conserved Domains (1) summary
    cl00738
    Location:86235
    MBOAT; membrane-bound O-acyltransferase family
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