Wipi2 WD repeat domain, phosphoinositide interacting 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wipi2provided by MGI
Official Full Name: WD repeat domain, phosphoinositide interacting 2provided by MGI
Primary source: MGI:MGI:1923831
See related: Ensembl:ENSMUSG00000029578 AllianceGenome:MGI:1923831
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110018O08Rik; 2510001I10Rik
Summary: Enables phosphatidylinositol-3-phosphate binding activity. Acts upstream of or within protein lipidation involved in autophagosome assembly; protein localization to phagophore assembly site; and xenophagy. Located in autophagosome and phagophore assembly site. Is expressed in cranial ganglion; dorsal root ganglion; submandibular gland primordium; telencephalon; and vibrissa epidermal component. Orthologous to human WIPI2 (WD repeat domain, phosphoinositide interacting 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 25.2), adrenal adult (RPKM 22.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 81.53 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (142615269..142655427)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (142629533..142669672)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuronal autophagy declines substantially with age and is rescued by overexpression of WIPI2.
Title: Neuronal autophagy declines substantially with age and is rescued by overexpression of WIPI2.
Importantly, ectopically expressing WIPI2B effectively restored autophagosome biogenesis in aged neurons.
Title: Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-5-phosphate binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy of peroxisome	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in glycophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein lipidation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein lipidation involved in autophagosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to phagophore assembly site	IPI Inferred from Physical Interaction more info	PubMed
involved_in protein localization to phagophore assembly site	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within xenophagy	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of membrane	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in phagophore assembly site	IDA Inferred from Direct Assay more info	PubMed
located_in phagophore assembly site	ISO Inferred from Sequence Orthology more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: WD repeat domain phosphoinositide-interacting protein 2

Names: WIPI-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417864.1 → NP_001404793.1 WD repeat domain phosphoinositide-interacting protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC105987, AC158310
NM_178398.5 → NP_848485.1 WD repeat domain phosphoinositide-interacting protein 2 isoform 1

See identical proteins and their annotated locations for NP_848485.1

Status: VALIDATED

Source sequence(s)

AC105987, AC158310

Consensus CDS

CCDS19828.1

UniProtKB/Swiss-Prot

Q80W47

UniProtKB/TrEMBL

D3YWK1

Related

ENSMUSP00000045201.10, ENSMUST00000036872.16

Conserved Domains (2) summary

COG2319
Location:21 → 272

WD40; WD40 repeat [General function prediction only]

sd00039
Location:143 → 182

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

142615269..142655427

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165568.1 → XP_036021461.1 WD repeat domain phosphoinositide-interacting protein 2 isoform X2

Conserved Domains (2) summary

sd00039
Location:10 → 50

7WD40; WD40 repeat [structural motif]

cl29593
Location:5 → 167

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...