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tagln transgelin [ Danio rerio (zebrafish) ]

Gene ID: 751758, updated on 27-Mar-2024

Summary

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Official Symbol
taglnprovided by ZNC
Official Full Name
transgelinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-1
See related
Ensembl:ENSDARG00000045408 AllianceGenome:ZFIN:ZDB-GENE-070912-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:153186
Summary
Predicted to be active in cytoskeleton. Is expressed in several structures, including artery; gut; hematopoietic stem cell; smooth muscle; and swim bladder bud. Orthologous to human TAGLN (transgelin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 15
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (543744..551220, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (582941..590374, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene finTRIM family, member 86 Neighboring gene proprotein convertase subtilisin/kexin type 7 Neighboring gene cerebellin 18 Neighboring gene cerebellin 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Phylogeny informs ontogeny: a proposed common theme in the arterial pole of the vertebrate heart. Grimes AC, et al. Evol Dev, 2010 Nov-Dec. PMID 21040422, Free PMC Article
  2. Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish. Chhabria K, et al. Dis Model Mech, 2019 Sep 25. PMID 31481433, Free PMC Article
  3. Characterization of zebrafish intestinal smooth muscle development using a novel sm22α-b promoter. Seiler C, et al. Dev Dyn, 2010 Nov. PMID 20882680, Free PMC Article
  4. Characterization of vascular mural cells during zebrafish development. Santoro MM, et al. Mech Dev, 2009 Aug-Sep. PMID 19539756, Free PMC Article
  5. The long Filamin-A isoform is required for intestinal development and motility: implications for chronic intestinal pseudo-obstruction. Zada A, et al. Hum Mol Genet, 2023 Jan 1. PMID 35981053, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC153186

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transgelin
Names
sm22
sm22alpha-b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045467.1 → NP_001038932.1  transgelin

    See identical proteins and their annotated locations for NP_001038932.1

    Status: PROVISIONAL

    Source sequence(s)
    BC122180
    UniProtKB/TrEMBL
    A0A8M1NAQ5, Q0P4B4
    Related
    ENSDARP00000066773.4, ENSDART00000066774.7
    Conserved Domains (3) summary
    COG5199
    Location:14 → 186
    SCP1; Calponin [Cytoskeleton]
    pfam00307
    Location:30 → 130
    CH; Calponin homology (CH) domain
    pfam00402
    Location:172 → 195
    Calponin; Calponin family repeat

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    543744..551220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021481469.1 → XP_021337144.1  transgelin isoform X1

    UniProtKB/TrEMBL
    A0A8M9QHD6
    Conserved Domains (1) summary
    cl27700
    Location:21 → 193
    Calponin; Calponin family repeat
Nucleotide Protein Strain
Heading Accession and Version

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