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Rnf19b ring finger protein 19B [ Mus musculus (house mouse) ]

Gene ID: 75234, updated on 5-Mar-2024

Summary

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Official Symbol
Rnf19bprovided by MGI
Official Full Name
ring finger protein 19Bprovided by MGI
Primary source
MGI:MGI:1922484
See related
Ensembl:ENSMUSG00000028793 AllianceGenome:MGI:1922484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ibrdc3; 4930534K13Rik; 4930555L03Rik
Summary
Predicted to enable ubiquitin binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein ligase activity. Acts upstream of or within natural killer cell mediated cytotoxicity. Located in cytolytic granule. Orthologous to human RNF19B (ring finger protein 19B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 168.3), ovary adult (RPKM 52.6) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf19b in Genome Data Viewer
Location:
4 D2.2; 4 62.76 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (128951871..128978319)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129058144..129084526)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E122 Neighboring gene adenylate kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E6222 Neighboring gene STARR-positive B cell enhancer ABC_E7990 Neighboring gene STARR-seq mESC enhancer starr_11473 Neighboring gene RIKEN cDNA 1700086P04 gene Neighboring gene STARR-positive B cell enhancer ABC_E10260 Neighboring gene STARR-positive B cell enhancer ABC_E3516 Neighboring gene transmembrane protein 54 Neighboring gene hippocalcin Neighboring gene STARR-positive B cell enhancer ABC_E4669 Neighboring gene fibronectin type III domain containing 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mice deficient in NKLAM have attenuated inflammatory cytokine production in a Sendai virus pneumonia model. Lawrence DW, et al. PLoS One, 2019. PMID 31539400, Free PMC Article
  2. Reduced inflammation and cytokine production in NKLAM deficient mice during Streptococcus pneumoniae infection. Lawrence DW, et al. PLoS One, 2018. PMID 29518136, Free PMC Article
  3. E3 ubiquitin ligase NKLAM positively regulates macrophage inducible nitric oxide synthase expression. Lawrence DW, et al. Immunobiology, 2015 Jan. PMID 25182373, Free PMC Article
  4. E3 ubiquitin ligase NKLAM is a macrophage phagosome protein and plays a role in bacterial killing. Lawrence DW, et al. Cell Immunol, 2012 Sep. PMID 23085241, Free PMC Article
  5. E3 ubiquitin ligase NKLAM ubiquitinates STAT1 and positively regulates STAT1-mediated transcriptional activity. Lawrence DW, et al. Cell Signal, 2016 Dec. PMID 27570112, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that natural killer lytic-associated molecule (NKLAM/RNF19b) plays a role in regulating the production of pro-inflammatory cytokines during viral infection.
    Title: Mice deficient in NKLAM have attenuated inflammatory cytokine production in a Sendai virus pneumonia model.
  2. E3 ubiquitin ligase NKLAM positively regulates macrophage inducible nitric oxide synthase expression.
    Title: E3 ubiquitin ligase NKLAM positively regulates macrophage inducible nitric oxide synthase expression.
  3. Data show that Natural Killer Lytic-Associated Molecule (NKLAM) is a component of macrophage phagosomes and is involved in macrophage bactericidal functions.
    Title: E3 ubiquitin ligase NKLAM is a macrophage phagosome protein and plays a role in bacterial killing.
  4. support the role for NKLAM in NK function both in vitro and in vivo.
    Title: Impaired NK cytolytic activity and enhanced tumor growth in NK lytic-associated molecule-deficient mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within type II interferon production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytolytic granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytolytic granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF19B
Names
IBR domain containing 3
IBR domain-containing protein 3
natural killer lytic-associated molecule
NP_001355692.1
NP_083495.1
XP_036020406.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368763.1 → NP_001355692.1  E3 ubiquitin-protein ligase RNF19B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606977
    Consensus CDS
    CCDS89829.1
    UniProtKB/Swiss-Prot
    A0AUN9, A2A7Q9, Q7TT05
    Related
    ENSMUSP00000030584.5, ENSMUST00000030584.11
    Conserved Domains (4) summary
    smart00647
    Location:184 → 248
    IBR; In Between Ring fingers
    pfam01485
    Location:280 → 318
    IBR; IBR domain, a half RING-finger domain
    cd16776
    Location:116 → 169
    RING-HC_RBR_RNF19B; RING finger, HC subclass, found in RING finger protein 19B (RNF19B) and similar proteins
    cl00570
    Location:344 → 433
    AzlC; AzlC protein

  2. NM_029219.2 → NP_083495.1  E3 ubiquitin-protein ligase RNF19B isoform 2

    See identical proteins and their annotated locations for NP_083495.1

    Status: VALIDATED

    Source sequence(s)
    AL606977
    Consensus CDS
    CCDS51305.1
    UniProtKB/TrEMBL
    E9Q2L7
    Related
    ENSMUSP00000131373.2, ENSMUST00000168461.8
    Conserved Domains (4) summary
    smart00647
    Location:184 → 248
    IBR; In Between Ring fingers
    pfam01485
    Location:279 → 317
    IBR; IBR domain, a half RING-finger domain
    pfam13639
    Location:116 → 163
    zf-RING_2; Ring finger domain
    cl00570
    Location:343 → 432
    AzlC; AzlC protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    128951871..128978319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164513.1 → XP_036020406.1  E3 ubiquitin-protein ligase RNF19B isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A7Q9.2 GenPept UniProtKB/Swiss-Prot:A2A7Q9

Gene LinkOut

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