Pelp1 proline, glutamic acid and leucine rich protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pelp1provided by MGI
Official Full Name: proline, glutamic acid and leucine rich protein 1provided by MGI
Primary source: MGI:MGI:1922523
See related: Ensembl:ENSMUSG00000018921 AllianceGenome:MGI:1922523
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MNAR; 4930563C04Rik
Summary: Predicted to enable several functions, including ATPase binding activity; SUMO binding activity; and protein N-terminus binding activity. Predicted to be involved in cellular response to estrogen stimulus and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus; nucleoplasm; and transcriptionally active chromatin. Predicted to be part of MLL1 complex. Is expressed in cerebral cortex; hypothalamus; and midbrain. Orthologous to human PELP1 (proline, glutamate and leucine rich protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 16.4), ovary adult (RPKM 15.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.99 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (70283709..70300862, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (70392881..70410031, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-195-5p is involved in testicular ischemia/reperfusion injury by directly targeting PELP1 and regulating spermatogonia pyroptosis.
Title: MiR-195-5p is involved in testicular ischemia/reperfusion injury by directly targeting PELP1 and regulating spermatogonia pyroptosis.
Recruitment of the protein complex 5FMC to Zbp-89, a zinc-finger transcription factor, affects its sumoylation status and transactivation potential.[5FMC]
Title: Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.
PELP1 is essential for the extranuclear signaling and neuroprotective actions of 17-beta estradiol in the hippocampal CA1 region after global cerebral ischemia.
Title: Proline-, glutamic acid-, and leucine-rich protein 1 mediates estrogen rapid signaling and neuroprotection in the brain.
These results further support the hypothesis that PELP1 deregulation has the potential to promote breast tumorigenesis in vivo and represent a novel model for future investigation into molecular mechanisms of PELP1-mediated tumorigenesis.
Title: PELP1 overexpression in the mouse mammary gland results in the development of hyperplasia and carcinoma.
PELP1 recruits HDAC2 and masks histones using two separate domains
Title: The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains.
Functional study of human homolog.
Title: Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pelp1 (e-PCR), detects polymorphism
- UniSTS:498759

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SUMO binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to estrogen stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MLL1 complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of euchromatin	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proline-, glutamic acid- and leucine-rich protein 1

Names: modulator of non-genomic activity of estrogen receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029231.5 → NP_083507.3 proline-, glutamic acid- and leucine-rich protein 1

See identical proteins and their annotated locations for NP_083507.3

Status: VALIDATED

Source sequence(s)

AL596096

Consensus CDS

CCDS24945.1

UniProtKB/Swiss-Prot

Q5F2E2, Q6PEM0, Q91YM9, Q9DBD5

UniProtKB/TrEMBL

A0A158SIT8

Related

ENSMUSP00000019065.4, ENSMUST00000019065.10

Conserved Domains (2) summary

pfam08166
Location:424 → 475

NUC202; NUC202 domain

pfam08167
Location:83 → 232

RIX1; rRNA processing/ribosome biogenesis