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Arhgap12 Rho GTPase activating protein 12 [ Mus musculus (house mouse) ]

Gene ID: 75415, updated on 5-Jan-2022

Summary

Official Symbol
Arhgap12provided by MGI
Official Full Name
Rho GTPase activating protein 12provided by MGI
Primary source
MGI:MGI:1922665
See related
Ensembl:ENSMUSG00000041225
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810011M08Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including negative regulation of small GTPase mediated signal transduction; phagocytosis, engulfment; and regulation of GTPase activity. Predicted to be located in phagocytic cup. Predicted to be active in cytoplasm. Is expressed in bladder; gut; nervous system; sensory organ; and skeleton. Orthologous to human ARHGAP12 (Rho GTPase activating protein 12). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in bladder adult (RPKM 10.7), CNS E14 (RPKM 8.1) and 25 other tissues See more
Orthologs
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Genomic context

See Arhgap12 in Genome Data Viewer
Location:
18; 18 A1
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (6024448..6136102, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (6024448..6136098, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (6024446..6136096, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34804 Neighboring gene predicted gene, 41663 Neighboring gene predicted gene, 41662 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene Neighboring gene predicted gene, 18278 Neighboring gene kinesin family member 5B Neighboring gene predicted gene, 41664 Neighboring gene ribosomal protein L27, pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
 
involved_in morphogenesis of an epithelial sheet ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in phagocytic cup ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 12
Names
rho-type GTPase-activating protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039692.1NP_001034781.1  rho GTPase-activating protein 12 isoform 1

    See identical proteins and their annotated locations for NP_001034781.1

    Status: VALIDATED

    Source sequence(s)
    AC168050, AK031648, AK077063, BC037608
    Consensus CDS
    CCDS37723.1
    UniProtKB/Swiss-Prot
    Q8C0D4
    Related
    ENSMUSP00000138585.2, ENSMUST00000182559.8
    Conserved Domains (6) summary
    cd12070
    Location:1372
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:266296
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:646831
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:457568
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:467566
    PH; PH domain
    pfam16618
    Location:69264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
  2. NM_029277.2NP_083553.2  rho GTPase-activating protein 12 isoform 2

    See identical proteins and their annotated locations for NP_083553.2

    Status: VALIDATED

    Source sequence(s)
    AC168050, AK077063, BC037608
    Consensus CDS
    CCDS37722.1
    UniProtKB/Swiss-Prot
    Q8C0D4
    UniProtKB/TrEMBL
    B2RUJ8
    Related
    ENSMUSP00000076376.6, ENSMUST00000077128.13
    Conserved Domains (6) summary
    cd12070
    Location:1372
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:266296
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:621806
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:432543
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:442541
    PH; PH domain
    pfam16618
    Location:69264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    6024448..6136102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250623.2XP_030106483.1  rho GTPase-activating protein 12 isoform X8

    Conserved Domains (4) summary
    cd12070
    Location:1372
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd04403
    Location:487672
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:298409
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69226
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
  2. XM_036161302.1XP_036017195.1  rho GTPase-activating protein 12 isoform X7

    Conserved Domains (4) summary
    cd12070
    Location:1372
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd04403
    Location:512697
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:323434
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69226
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
  3. XM_017318001.2XP_017173490.1  rho GTPase-activating protein 12 isoform X6

    Conserved Domains (4) summary
    cd12070
    Location:1372
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd04403
    Location:517702
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:328439
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69226
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
  4. XM_006526316.2XP_006526379.1  rho GTPase-activating protein 12 isoform X5

    UniProtKB/TrEMBL
    S4R203
    Related
    ENSMUSP00000138444.2, ENSMUST00000182383.8
    Conserved Domains (6) summary
    cd12070
    Location:1372
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    COG5104
    Location:257362
    PRP40; Splicing factor [RNA processing and modification]
    cd00201
    Location:266296
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:574759
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:385496
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
  5. XM_036161301.1XP_036017194.1  rho GTPase-activating protein 12 isoform X4

    Related
    ENSMUSP00000138496.2, ENSMUST00000182066.8
    Conserved Domains (6) summary
    cd12070
    Location:1372
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    COG5104
    Location:257362
    PRP40; Splicing factor [RNA processing and modification]
    cd00201
    Location:266296
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:599784
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:410521
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
  6. XM_006526315.2XP_006526378.1  rho GTPase-activating protein 12 isoform X3

    UniProtKB/TrEMBL
    A0A0A0MQ95
    Related
    ENSMUSP00000054209.8, ENSMUST00000062584.14
    Conserved Domains (6) summary
    cd12070
    Location:1372
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    COG5104
    Location:257362
    PRP40; Splicing factor [RNA processing and modification]
    cd00201
    Location:266296
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:604789
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:415526
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
  7. XM_011247018.2XP_011245320.1  rho GTPase-activating protein 12 isoform X2

    Conserved Domains (6) summary
    cd12070
    Location:1372
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    COG5104
    Location:257409
    PRP40; Splicing factor [RNA processing and modification]
    cd00201
    Location:266296
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:626811
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:437548
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
  8. XM_006526314.2XP_006526377.1  rho GTPase-activating protein 12 isoform X1

    UniProtKB/TrEMBL
    S4R221
    Related
    ENSMUSP00000138464.2, ENSMUST00000182213.8
    Conserved Domains (6) summary
    cd12070
    Location:1372
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    COG5104
    Location:257409
    PRP40; Splicing factor [RNA processing and modification]
    cd00201
    Location:266296
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:651836
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:462573
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
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