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ZFY zinc finger protein Y-linked [ Homo sapiens (human) ]

Gene ID: 7544, updated on 5-Mar-2024

Summary

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Official Symbol
ZFYprovided by HGNC
Official Full Name
zinc finger protein Y-linkedprovided by HGNC
Primary source
HGNC:HGNC:12870
See related
Ensembl:ENSG00000067646 MIM:490000; AllianceGenome:HGNC:12870
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF911
Summary
This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [provided by RefSeq, Jul 2008]
Annotation information
Note: This gene is annotated on the Y chromosome of the reference genome and HuRef assemblies but is annotated on the X chromosome of the Celera assembly (as gene LOC100130829 and model XM_001713692.1). [18 Feb 2009]
Expression
Broad expression in testis (RPKM 3.4), prostate (RPKM 3.2) and 20 other tissues See more
Orthologs
all
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Genomic context

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Location:
Yp11.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (2935381..2982506)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (2611525..2659668)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (2803422..2850547)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene heat shock transcription factor Y-linked 3, pseudogene Neighboring gene nucleosome assembly protein 1 like 1 pseudogene 2 Neighboring gene ZFY antisense RNA 1 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 41 Neighboring gene long intergenic non-protein coding RNA 278 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:2956017-2956558

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Onset of sex differentiation: dialog between genes and cells. Merchant-Larios H, et al. Arch Med Res, 2001 Nov-Dec. PMID 11750730
  2. Three thousand years of questioning sex determination. Mittwoch U. Cytogenet Cell Genet, 2000. PMID 11173854
  3. Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans. Erlandsson R, et al. Mol Biol Evol, 2000 May. PMID 10779541
  4. ZFY gene expression and retention in human prostate adenocarcinoma. Tricoli JV, et al. Genes Chromosomes Cancer, 1993 Feb. PMID 7680890
  5. The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues. Lau YF, et al. Am J Hum Genet, 1989 Dec. PMID 2511751, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.
    Title: Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.
  2. Studies identified a major testis-specific ZFY transcript that encodes a protein with the same short acidic domain.
    Title: Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC138710

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger Y-chromosomal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008113.1 RefSeqGene

    Range
    4877..52002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145275.2 → NP_001138747.1  zinc finger Y-chromosomal protein isoform 2

    See identical proteins and their annotated locations for NP_001138747.1

    Status: REVIEWED

    Source sequence(s)
    AC006157
    Consensus CDS
    CCDS48201.1
    UniProtKB/TrEMBL
    B7ZKJ5
    Related
    ENSP00000393908.1, ENST00000449237.4
    Conserved Domains (5) summary
    COG5048
    Location:462 → 599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:409 → 429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam04704
    Location:45 → 329
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam00096
    Location:638 → 660
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:481 → 505
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001145276.2 → NP_001138748.1  zinc finger Y-chromosomal protein isoform 3

    See identical proteins and their annotated locations for NP_001138748.1

    Status: REVIEWED

    Source sequence(s)
    AC006157
    Consensus CDS
    CCDS48200.1
    UniProtKB/TrEMBL
    Q8WXB7
    Related
    ENSP00000485605.1, ENST00000625061.3
    Conserved Domains (5) summary
    COG5048
    Location:348 → 485
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:295 → 315
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam04704
    Location:22 → 215
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:367 → 389
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:232 → 248
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  3. NM_001369702.1 → NP_001356631.1  zinc finger Y-chromosomal protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC006157
    Consensus CDS
    CCDS14774.1
    UniProtKB/Swiss-Prot
    B4DVF7, P08048, Q14021, Q15558, Q1RME9, Q24JR0, Q96TF3
    Related
    ENSP00000372525.1, ENST00000383052.5
    Conserved Domains (5) summary
    COG5048
    Location:539 → 676
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486 → 506
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam04704
    Location:71 → 406
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam00096
    Location:715 → 737
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:558 → 582
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001369703.1 → NP_001356632.1  zinc finger Y-chromosomal protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC006157
    Conserved Domains (5) summary
    COG5048
    Location:513 → 650
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:460 → 480
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam04704
    Location:45 → 380
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam00096
    Location:689 → 711
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:532 → 556
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001369704.1 → NP_001356633.1  zinc finger Y-chromosomal protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC006157
    Conserved Domains (5) summary
    COG5048
    Location:513 → 650
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:460 → 480
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam04704
    Location:45 → 380
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam00096
    Location:689 → 711
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:532 → 556
    zf-H2C2_2; Zinc-finger double domain

  6. NM_001369705.1 → NP_001356634.1  zinc finger Y-chromosomal protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC006157
    Conserved Domains (5) summary
    COG5048
    Location:513 → 650
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:460 → 480
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam04704
    Location:45 → 380
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam00096
    Location:689 → 711
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:532 → 556
    zf-H2C2_2; Zinc-finger double domain

  7. NM_001369706.1 → NP_001356635.1  zinc finger Y-chromosomal protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC006157
    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (5) summary
    COG5048
    Location:488 → 625
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:435 → 455
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam04704
    Location:71 → 355
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam00096
    Location:664 → 686
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:507 → 531
    zf-H2C2_2; Zinc-finger double domain

  8. NM_001369707.1 → NP_001356636.1  zinc finger Y-chromosomal protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC006157
    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (5) summary
    COG5048
    Location:488 → 625
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:435 → 455
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam04704
    Location:71 → 355
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam00096
    Location:664 → 686
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:507 → 531
    zf-H2C2_2; Zinc-finger double domain

  9. NM_001369708.1 → NP_001356637.1  zinc finger Y-chromosomal protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC006157
    Consensus CDS
    CCDS48201.1
    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (5) summary
    COG5048
    Location:462 → 599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:409 → 429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam04704
    Location:45 → 329
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam00096
    Location:638 → 660
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:481 → 505
    zf-H2C2_2; Zinc-finger double domain

  10. NM_001369709.1 → NP_001356638.1  zinc finger Y-chromosomal protein isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC006157
    UniProtKB/TrEMBL
    Q8WXB7
    Conserved Domains (5) summary
    COG5048
    Location:297 → 434
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:244 → 264
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam04704
    Location:22 → 164
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:316 → 340
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:181 → 199
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  11. NM_001369710.1 → NP_001356639.1  zinc finger Y-chromosomal protein isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC006157
    UniProtKB/TrEMBL
    Q8WXB7
    Conserved Domains (5) summary
    COG5048
    Location:255 → 392
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:202 → 222
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:233 → 254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam04704
    Location:2 → 122
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    cl19880
    Location:139 → 157
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  12. NM_003411.4 → NP_003402.2  zinc finger Y-chromosomal protein isoform 1

    See identical proteins and their annotated locations for NP_003402.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AC006157, AI469059, AI763177, AL137603, BC114526, M30607
    Consensus CDS
    CCDS14774.1
    UniProtKB/Swiss-Prot
    B4DVF7, P08048, Q14021, Q15558, Q1RME9, Q24JR0, Q96TF3
    Related
    ENSP00000155093.3, ENST00000155093.8
    Conserved Domains (5) summary
    COG5048
    Location:539 → 676
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486 → 506
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam04704
    Location:71 → 406
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam00096
    Location:715 → 737
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:558 → 582
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    2935381..2982506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017030075.2 → XP_016885564.1  zinc finger Y-chromosomal protein isoform X1

    UniProtKB/Swiss-Prot
    B4DVF7, P08048, Q14021, Q15558, Q1RME9, Q24JR0, Q96TF3
    Conserved Domains (5) summary
    COG5048
    Location:539 → 676
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486 → 506
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam04704
    Location:71 → 406
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam00096
    Location:715 → 737
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:558 → 582
    zf-H2C2_2; Zinc-finger double domain

  2. XM_047442758.1 → XP_047298714.1  zinc finger Y-chromosomal protein isoform X1

    UniProtKB/Swiss-Prot
    B4DVF7, P08048, Q14021, Q15558, Q1RME9, Q24JR0, Q96TF3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    2611525..2659668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328361.1 → XP_054184336.1  zinc finger Y-chromosomal protein isoform X1

    UniProtKB/Swiss-Prot
    B4DVF7, P08048, Q14021, Q15558, Q1RME9, Q24JR0, Q96TF3

  2. XM_054328362.1 → XP_054184337.1  zinc finger Y-chromosomal protein isoform X1

    UniProtKB/Swiss-Prot
    B4DVF7, P08048, Q14021, Q15558, Q1RME9, Q24JR0, Q96TF3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08048.3 GenPept UniProtKB/Swiss-Prot:P08048

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