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Akap13 A kinase (PRKA) anchor protein 13 [ Mus musculus (house mouse) ]

Gene ID: 75547, updated on 23-Jun-2021

Summary

Official Symbol
Akap13provided by MGI
Official Full Name
A kinase (PRKA) anchor protein 13provided by MGI
Primary source
MGI:MGI:2676556
See related
Ensembl:ENSMUSG00000066406
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BRX; LBC; PRO; AKAP; Ht31; PROT; AKAP-13; AKAP-Lbc; PROTO-LB; PROTO-LBC; 1700026G02Rik; 5730522G15Rik; 5830460E08Rik
Expression
Ubiquitous expression in spleen adult (RPKM 15.7), lung adult (RPKM 14.2) and 28 other tissues See more
Orthologs
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Genomic context

See Akap13 in Genome Data Viewer
Location:
7; 7 D1
Exon count:
42
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (75105271..75404357)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (75455526..75754609)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (82600420..82899495)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S28 pseudogene Neighboring gene predicted gene, 46017 Neighboring gene CRISPRi-validated cis-regulatory element for Akap13 Neighboring gene expressed sequence AU020206 Neighboring gene predicted gene, 51489

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MAP-kinase scaffold activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP-kinase scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables cAMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase A binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in nuclear export ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of glucocorticoid mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of sarcomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with actin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
A-kinase anchor protein 13
Names
type II cAMP-dependent protein kinase anchoring protein Ht31

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029332.1NP_083608.1  A-kinase anchor protein 13

    Status: VALIDATED

    Source sequence(s)
    AC113019, AC158749
    Consensus CDS
    CCDS52276.1
    UniProtKB/Swiss-Prot
    E9Q394
    Related
    ENSMUSP00000129784.2, ENSMUST00000166315.7
    Conserved Domains (6) summary
    cd00160
    Location:19582152
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13392
    Location:21952297
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    pfam00169
    Location:21952295
    PH; PH domain
    pfam02050
    Location:25352645
    FliJ; Flagellar FliJ protein
    cl00040
    Location:17551801
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl02529
    Location:165219
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    75105271..75404357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153520.1XP_036009413.1  A-kinase anchor protein 13 isoform X1

    Conserved Domains (5) summary
    cd00160
    Location:19992193
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:25192674
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13392
    Location:22362338
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cd20878
    Location:17921848
    C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
    NF033909
    Location:11501298
    opacity_OapA; opacity-associated protein OapA
  2. XM_036153522.1XP_036009415.1  A-kinase anchor protein 13 isoform X3

    Conserved Domains (6) summary
    PRK12704
    Location:26162686
    PRK12704; phosphodiesterase; Provisional
    cd00160
    Location:19992193
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:25322673
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13392
    Location:22362338
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cd20878
    Location:17921848
    C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
    NF033909
    Location:11501298
    opacity_OapA; opacity-associated protein OapA
  3. XM_036153521.1XP_036009414.1  A-kinase anchor protein 13 isoform X2

    Conserved Domains (5) summary
    cd00160
    Location:19982192
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:25182673
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13392
    Location:22352337
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cd20878
    Location:17921848
    C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
    NF033909
    Location:11501298
    opacity_OapA; opacity-associated protein OapA
  4. XM_036153523.1XP_036009416.1  A-kinase anchor protein 13 isoform X4

    Conserved Domains (5) summary
    cd00160
    Location:19972191
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:25172672
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13392
    Location:22342336
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cd20878
    Location:17921848
    C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
    NF033909
    Location:11501298
    opacity_OapA; opacity-associated protein OapA
  5. XM_036153525.1XP_036009418.1  A-kinase anchor protein 13 isoform X6

    Conserved Domains (6) summary
    PRK12704
    Location:25952665
    PRK12704; phosphodiesterase; Provisional
    cd00160
    Location:19772171
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:24972652
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13392
    Location:22142316
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cd20878
    Location:17701826
    C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
    NF033909
    Location:11501298
    opacity_OapA; opacity-associated protein OapA
  6. XM_036153526.1XP_036009419.1  A-kinase anchor protein 13 isoform X8

    Conserved Domains (6) summary
    PRK12704
    Location:25932663
    PRK12704; phosphodiesterase; Provisional
    cd00160
    Location:19752169
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:24952650
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13392
    Location:22122314
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cd20878
    Location:17701826
    C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
    NF033909
    Location:11501298
    opacity_OapA; opacity-associated protein OapA
  7. XM_036153524.1XP_036009417.1  A-kinase anchor protein 13 isoform X5

    Conserved Domains (5) summary
    cd00160
    Location:19812175
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:25012656
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13392
    Location:22182320
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cd20878
    Location:17741830
    C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
    NF033909
    Location:11501298
    opacity_OapA; opacity-associated protein OapA
  8. XM_036153527.1XP_036009420.1  A-kinase anchor protein 13 isoform X9

    Conserved Domains (6) summary
    PRK12704
    Location:25772647
    PRK12704; phosphodiesterase; Provisional
    cd00160
    Location:19592153
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:24792634
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13392
    Location:21962298
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cd20878
    Location:17521808
    C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
    NF033909
    Location:11501298
    opacity_OapA; opacity-associated protein OapA
  9. XM_036153528.1XP_036009421.1  A-kinase anchor protein 13 isoform X11

    Conserved Domains (6) summary
    PRK12704
    Location:25752645
    PRK12704; phosphodiesterase; Provisional
    cd00160
    Location:19572151
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:24772632
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13392
    Location:21942296
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cd20878
    Location:17521808
    C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
    NF033909
    Location:11501298
    opacity_OapA; opacity-associated protein OapA
  10. XM_006541256.4XP_006541319.1  A-kinase anchor protein 13 isoform X7

    UniProtKB/TrEMBL
    A0A140LJJ5
    Related
    ENSMUSP00000147237.2, ENSMUST00000207750.2
    Conserved Domains (5) summary
    cd00160
    Location:19762170
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:25532676
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR03835
    Location:450835
    termin_org_DnaJ; terminal organelle assembly protein TopJ
    cd13392
    Location:22132315
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cl00040
    Location:17731819
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  11. XM_006541254.5XP_006541317.1  A-kinase anchor protein 13 isoform X12

    Conserved Domains (5) summary
    cd00160
    Location:19542148
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:25312654
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR03835
    Location:450835
    termin_org_DnaJ; terminal organelle assembly protein TopJ
    cd13392
    Location:21912293
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cl00040
    Location:17511797
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  12. XM_006541253.5XP_006541316.1  A-kinase anchor protein 13 isoform X10

    Conserved Domains (5) summary
    cd00160
    Location:19582152
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:25352658
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR03835
    Location:450835
    termin_org_DnaJ; terminal organelle assembly protein TopJ
    cd13392
    Location:21952297
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cl00040
    Location:17551801
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  13. XM_006541255.5XP_006541318.1  A-kinase anchor protein 13 isoform X13

    UniProtKB/Swiss-Prot
    E9Q394
    Conserved Domains (5) summary
    cd00160
    Location:19362130
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:25132636
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR03835
    Location:450835
    termin_org_DnaJ; terminal organelle assembly protein TopJ
    cd13392
    Location:21732275
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cl00040
    Location:17331779
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  14. XM_030243062.2XP_030098922.1  A-kinase anchor protein 13 isoform X14

    Conserved Domains (5) summary
    cd00160
    Location:19352129
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:25122635
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR03835
    Location:450835
    termin_org_DnaJ; terminal organelle assembly protein TopJ
    cd13392
    Location:21722274
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cl00040
    Location:17331779
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  15. XM_036153529.1XP_036009422.1  A-kinase anchor protein 13 isoform X15

    Conserved Domains (6) summary
    PRK12704
    Location:24092479
    PRK12704; phosphodiesterase; Provisional
    cd00160
    Location:17911985
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:23112466
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13392
    Location:20282130
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cd20878
    Location:15841640
    C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
    NF033909
    Location:9421090
    opacity_OapA; opacity-associated protein OapA
  16. XM_036153530.1XP_036009423.1  A-kinase anchor protein 13 isoform X16

    Conserved Domains (5) summary
    PRK12704
    Location:13101380
    PRK12704; phosphodiesterase; Provisional
    cd00160
    Location:692886
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:12121367
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13392
    Location:9291031
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cd20878
    Location:485541
    C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
  17. XM_006541258.5XP_006541321.1  A-kinase anchor protein 13 isoform X17

    Conserved Domains (4) summary
    cd00160
    Location:669863
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:12461369
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13392
    Location:9061008
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cl00040
    Location:466512
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  18. XM_036153531.1XP_036009424.1  A-kinase anchor protein 13 isoform X18

    Conserved Domains (5) summary
    PRK12704
    Location:12851355
    PRK12704; phosphodiesterase; Provisional
    cd00160
    Location:667861
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:11871342
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13392
    Location:9041006
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cd20878
    Location:462518
    C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
  19. XM_030243065.2XP_030098925.1  A-kinase anchor protein 13 isoform X21

    Conserved Domains (4) summary
    cd00160
    Location:629823
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:12061329
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13392
    Location:866968
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cl00040
    Location:426472
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  20. XM_006541259.5XP_006541322.1  A-kinase anchor protein 13 isoform X19

    Conserved Domains (4) summary
    cd00160
    Location:654848
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:12311354
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13392
    Location:891993
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cl00040
    Location:451497
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  21. XM_036153532.1XP_036009425.1  A-kinase anchor protein 13 isoform X20

    Conserved Domains (5) summary
    PRK12704
    Location:12541324
    PRK12704; phosphodiesterase; Provisional
    cd00160
    Location:636830
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:11561311
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13392
    Location:873975
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cd20878
    Location:429485
    C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
  22. XM_006541260.5XP_006541323.1  A-kinase anchor protein 13 isoform X22

    Conserved Domains (4) summary
    cd00160
    Location:614808
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:11911314
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13392
    Location:851953
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cl00040
    Location:411457
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  23. XM_036153533.1XP_036009426.1  A-kinase anchor protein 13 isoform X23

    Conserved Domains (5) summary
    PRK12704
    Location:12311301
    PRK12704; phosphodiesterase; Provisional
    cd00160
    Location:613807
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02168
    Location:11331288
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd13392
    Location:850952
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cd20878
    Location:407463
    C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
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