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Fggy FGGY carbohydrate kinase domain containing [ Mus musculus (house mouse) ]

Gene ID: 75578, updated on 21-Apr-2024

Summary

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Official Symbol
Fggyprovided by MGI
Official Full Name
FGGY carbohydrate kinase domain containingprovided by MGI
Primary source
MGI:MGI:1922828
See related
Ensembl:ENSMUSG00000028573 AllianceGenome:MGI:1922828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310009E04Rik
Summary
Predicted to enable D-ribulokinase activity. Predicted to be involved in carbohydrate phosphorylation; neuron cellular homeostasis; and pentose metabolic process. Predicted to act upstream of or within phosphorylation. Is expressed in liver lobe; metanephros; and olfactory epithelium. Orthologous to human FGGY (FGGY carbohydrate kinase domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 11.8), liver adult (RPKM 8.7) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 C5; 4 43.83 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (95445717..95815176)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (95557480..95926939)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1032 Neighboring gene predicted gene, 25004 Neighboring gene predicted gene, 40206 Neighboring gene STARR-seq mESC enhancer starr_10810 Neighboring gene STARR-seq mESC enhancer starr_10811 Neighboring gene STARR-seq mESC enhancer starr_10812 Neighboring gene STARR-seq mESC enhancer starr_10813 Neighboring gene STARR-seq mESC enhancer starr_10814 Neighboring gene RIKEN cDNA 9530080O11 gene Neighboring gene STARR-positive B cell enhancer ABC_E1647 Neighboring gene STARR-seq mESC enhancer starr_10816 Neighboring gene hook microtubule tethering protein 1 Neighboring gene STARR-seq mESC enhancer starr_10817 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 13 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FGGY carbohydrate kinase domain containing is expressed and alternatively spliced in skeletal muscle and attenuates MAP kinase and Akt signaling. Smith AL, et al. Gene, 2021 Oct 20. PMID 34280510
  2. Prenatal Exposure to Bisphenol A Disrupts Naturally Occurring Bimodal DNA Methylation at Proximal Promoter of fggy, an Obesity-Relevant Gene Encoding a Carbohydrate Kinase, in Gonadal White Adipose Tissues of CD-1 Mice. Taylor JA, et al. Endocrinology, 2018 Feb 1. PMID 29220483, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FGGY carbohydrate kinase domain containing is expressed and alternatively spliced in skeletal muscle and attenuates MAP kinase and Akt signaling.
    Title: FGGY carbohydrate kinase domain containing is expressed and alternatively spliced in skeletal muscle and attenuates MAP kinase and Akt signaling.
  2. The strength of Fggy mRNA expression significantly correlated with increased whole body weight and gonadal fat weight of males but not females.
    Title: Prenatal Exposure to Bisphenol A Disrupts Naturally Occurring Bimodal DNA Methylation at Proximal Promoter of fggy, an Obesity-Relevant Gene Encoding a Carbohydrate Kinase, in Gonadal White Adipose Tissues of CD-1 Mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC118640, RP23-472I13.1

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-ribulokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-ribulokinase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in pentose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pentose metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
FGGY carbohydrate kinase domain-containing protein
Names
D-ribulokinase FGGY
NP_001106883.1
NP_083623.1
XP_006503524.1
XP_006503531.1
XP_006503535.1
XP_006503537.1
XP_006503539.1
XP_011238935.1
XP_011238937.1
XP_011238938.1
XP_011238939.1
XP_011238941.1
XP_011238945.1
XP_011238946.1
XP_011238947.1
XP_017175919.1
XP_017175920.1
XP_030109730.1
XP_030109731.1
XP_030109732.1
XP_030109733.1
XP_030109734.1
XP_036020408.1
XP_036020409.1
XP_036020410.1
XP_036020411.1
XP_036020412.1
XP_036020413.1
XP_036020414.1
XP_036020415.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113412.1 → NP_001106883.1  FGGY carbohydrate kinase domain-containing protein isoform a

    See identical proteins and their annotated locations for NP_001106883.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK009249, AK138439, BX519665, BY073369
    Consensus CDS
    CCDS51233.1
    UniProtKB/Swiss-Prot
    A2AJL3, Q8BUF2, Q8K0F0, Q9D7H0
    UniProtKB/TrEMBL
    A0A8X8M4B3
    Related
    ENSMUSP00000078216.5, ENSMUST00000079223.11
    Conserved Domains (1) summary
    cd07782
    Location:11 → 545
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  2. NM_029347.2 → NP_083623.1  FGGY carbohydrate kinase domain-containing protein isoform b

    See identical proteins and their annotated locations for NP_083623.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' and 3' exon structure compared to variant 1. It encodes isoform b, which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK085534, AL772131, AL844609, BX005293, BY755248, CB953569
    Consensus CDS
    CCDS18365.1
    UniProtKB/TrEMBL
    A0A8X8RHI6
    Related
    ENSMUSP00000043460.5, ENSMUST00000043335.11
    Conserved Domains (1) summary
    cd07782
    Location:11 → 364
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    95445717..95815176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320430.3 → XP_017175919.1  FGGY carbohydrate kinase domain-containing protein isoform X8

    Conserved Domains (1) summary
    cd07782
    Location:11 → 433
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  2. XM_030253871.2 → XP_030109731.1  FGGY carbohydrate kinase domain-containing protein isoform X11

    UniProtKB/TrEMBL
    A0A8X8M4B3
    Conserved Domains (1) summary
    cd07782
    Location:11 → 509
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  3. XM_017320431.1 → XP_017175920.1  FGGY carbohydrate kinase domain-containing protein isoform X20

    Conserved Domains (1) summary
    cd07782
    Location:19 → 406
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  4. XM_006503472.5 → XP_006503535.1  FGGY carbohydrate kinase domain-containing protein isoform X18

    Related
    ENSMUST00000176162.8
    Conserved Domains (1) summary
    cd07782
    Location:11 → 434
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  5. XM_030253872.2 → XP_030109732.1  FGGY carbohydrate kinase domain-containing protein isoform X24

    UniProtKB/TrEMBL
    A0A8X8RHI6
    Conserved Domains (1) summary
    cd07782
    Location:11 → 364
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  6. XM_036164521.1 → XP_036020414.1  FGGY carbohydrate kinase domain-containing protein isoform X22

    Conserved Domains (1) summary
    cd07782
    Location:19 → 420
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  7. XM_030253874.1 → XP_030109734.1  FGGY carbohydrate kinase domain-containing protein isoform X25

    Conserved Domains (1) summary
    cl17037
    Location:2 → 336
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  8. XM_006503474.2 → XP_006503537.1  FGGY carbohydrate kinase domain-containing protein isoform X21

    UniProtKB/TrEMBL
    A2AJL4
    Conserved Domains (1) summary
    cd07782
    Location:1 → 432
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  9. XM_011240644.1 → XP_011238946.1  FGGY carbohydrate kinase domain-containing protein isoform X17

    Conserved Domains (1) summary
    cd07782
    Location:19 → 441
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  10. XM_011240637.2 → XP_011238939.1  FGGY carbohydrate kinase domain-containing protein isoform X7

    UniProtKB/TrEMBL
    A0A8X8M4B3
    Conserved Domains (1) summary
    cd07782
    Location:19 → 517
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  11. XM_011240645.1 → XP_011238947.1  FGGY carbohydrate kinase domain-containing protein isoform X19

    UniProtKB/TrEMBL
    A0A8X8M4B3
    Conserved Domains (1) summary
    cd07782
    Location:19 → 447
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  12. XM_036164515.1 → XP_036020408.1  FGGY carbohydrate kinase domain-containing protein isoform X3

    UniProtKB/TrEMBL
    A0A8X8M4B3
    Conserved Domains (1) summary
    cd07782
    Location:19 → 516
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  13. XM_036164518.1 → XP_036020411.1  FGGY carbohydrate kinase domain-containing protein isoform X12

    Conserved Domains (1) summary
    cd07782
    Location:19 → 441
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  14. XM_011240636.2 → XP_011238938.1  FGGY carbohydrate kinase domain-containing protein isoform X4

    UniProtKB/TrEMBL
    A0A8X8M4B3
    Conserved Domains (1) summary
    cd07782
    Location:19 → 515
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  15. XM_036164516.1 → XP_036020409.1  FGGY carbohydrate kinase domain-containing protein isoform X6

    Conserved Domains (1) summary
    cd07782
    Location:19 → 441
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  16. XM_036164517.1 → XP_036020410.1  FGGY carbohydrate kinase domain-containing protein isoform X10

    UniProtKB/TrEMBL
    A0A8X8M4B3
    Conserved Domains (1) summary
    cd07782
    Location:19 → 513
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  17. XM_036164519.1 → XP_036020412.1  FGGY carbohydrate kinase domain-containing protein isoform X13

    Conserved Domains (1) summary
    cd07782
    Location:19 → 441
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  18. XM_011240635.1 → XP_011238937.1  FGGY carbohydrate kinase domain-containing protein isoform X5

    UniProtKB/TrEMBL
    A0A8X8M4B3
    Conserved Domains (1) summary
    cd07782
    Location:19 → 513
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  19. XM_006503468.4 → XP_006503531.1  FGGY carbohydrate kinase domain-containing protein isoform X14

    Conserved Domains (1) summary
    cd07782
    Location:19 → 441
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  20. XM_036164520.1 → XP_036020413.1  FGGY carbohydrate kinase domain-containing protein isoform X16

    Conserved Domains (1) summary
    cd07782
    Location:19 → 441
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  21. XM_011240639.4 → XP_011238941.1  FGGY carbohydrate kinase domain-containing protein isoform X9

    UniProtKB/TrEMBL
    A0A8X8M4B3
    Conserved Domains (1) summary
    cd07782
    Location:19 → 514
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  22. XM_011240643.2 → XP_011238945.1  FGGY carbohydrate kinase domain-containing protein isoform X15

    Conserved Domains (1) summary
    cd07782
    Location:19 → 442
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  23. XM_036164522.1 → XP_036020415.1  FGGY carbohydrate kinase domain-containing protein isoform X23

    UniProtKB/TrEMBL
    A0A8X8RHI6
    Conserved Domains (1) summary
    cd07782
    Location:19 → 372
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  24. XM_011240633.2 → XP_011238935.1  FGGY carbohydrate kinase domain-containing protein isoform X1

    UniProtKB/TrEMBL
    A0A8X8M4B3
    Conserved Domains (1) summary
    cd07782
    Location:19 → 553
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  25. XM_006503461.4 → XP_006503524.1  FGGY carbohydrate kinase domain-containing protein isoform X2

    See identical proteins and their annotated locations for XP_006503524.1

    UniProtKB/Swiss-Prot
    A2AJL3, Q8BUF2, Q8K0F0, Q9D7H0
    UniProtKB/TrEMBL
    A0A8X8M4B3
    Conserved Domains (1) summary
    cd07782
    Location:11 → 545
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  26. XM_030253873.2 → XP_030109733.1  FGGY carbohydrate kinase domain-containing protein isoform X25

    Conserved Domains (1) summary
    cl17037
    Location:2 → 336
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  27. XM_030253870.2 → XP_030109730.1  FGGY carbohydrate kinase domain-containing protein isoform X11

    UniProtKB/TrEMBL
    A0A8X8M4B3
    Conserved Domains (1) summary
    cd07782
    Location:11 → 509
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

  28. XM_006503476.1 → XP_006503539.1  FGGY carbohydrate kinase domain-containing protein isoform X26

    See identical proteins and their annotated locations for XP_006503539.1

    UniProtKB/Swiss-Prot
    A2AJL3
    Conserved Domains (1) summary
    cl17037
    Location:1 → 245
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AJL3.1 GenPept UniProtKB/Swiss-Prot:A2AJL3

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