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Ipo4 importin 4 [ Mus musculus (house mouse) ]

Gene ID: 75751, updated on 23-Jun-2021

Summary

Official Symbol
Ipo4provided by MGI
Official Full Name
importin 4provided by MGI
Primary source
MGI:MGI:1923001
See related
Ensembl:ENSMUSG00000002319
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Imp4a; RanBP4; AA409693; 8430408O15Rik
Expression
Ubiquitous expression in testis adult (RPKM 123.0), ovary adult (RPKM 46.1) and 28 other tissues See more
Orthologs
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Genomic context

See Ipo4 in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
30
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55862857..55873321, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55625400..55635868, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (56244466..56254515, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene interferon regulatory factor 9 Neighboring gene REC8 meiotic recombination protein Neighboring gene transmembrane 9 superfamily member 1 Neighboring gene testis-specific serine kinase 4 Neighboring gene magnesium-dependent phosphatase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC113723

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA replication-dependent nucleosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA replication-independent nucleosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein import into nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ribosome biogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
importin-4
Names
imp4
importin 4a
ran-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360078.1NP_001347007.1  importin-4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK030490, AK147086, BM950244
    Conserved Domains (3) summary
    smart00913
    Location:2490
    IBN_N; Importin-beta N-terminal domain
    COG5215
    Location:353620
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:353381
    HEAT; HEAT repeat [structural motif]
  2. NM_024267.7NP_077229.4  importin-4 isoform 1

    See identical proteins and their annotated locations for NP_077229.4

    Status: VALIDATED

    Source sequence(s)
    AK030490, AK147086
    Consensus CDS
    CCDS27121.1
    UniProtKB/Swiss-Prot
    Q8VI75
    Related
    ENSMUSP00000036555.10, ENSMUST00000047131.16
    Conserved Domains (2) summary
    smart00913
    Location:2490
    IBN_N; Importin-beta N-terminal domain
    sd00044
    Location:353381
    HEAT; HEAT repeat [structural motif]

RNA

  1. NR_153401.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK030490, AK147086, BC085150
    Related
    ENSMUST00000135221.8
  2. NR_153402.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK018399, AK030490, AK147086
    Related
    ENSMUST00000148351.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55862857..55873321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316220.3XP_017171709.1  importin-4 isoform X1

    Conserved Domains (2) summary
    COG5215
    Location:153420
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:153181
    HEAT; HEAT repeat [structural motif]
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