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Rnf139 ring finger protein 139 [ Mus musculus (house mouse) ]

Gene ID: 75841, updated on 23-Jun-2021

Summary

Official Symbol
Rnf139provided by MGI
Official Full Name
ring finger protein 139provided by MGI
Primary source
MGI:MGI:1923091
See related
Ensembl:ENSMUSG00000037075
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930555P18Rik
Expression
Broad expression in testis adult (RPKM 73.5), liver E14 (RPKM 11.8) and 24 other tissues See more
Orthologs
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Genomic context

See Rnf139 in Genome Data Viewer
Location:
15; 15 D1
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58760975..58774239)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58889229..58902390)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (58720784..58733945)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 12 Neighboring gene predicted gene, 36509 Neighboring gene TatD DNase domain containing 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 Neighboring gene MTSS I-BAR domain containing 1 Neighboring gene RIKEN cDNA 4930544F09 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-like protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ER to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein processing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Derlin-1 retrotranslocation complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF139
Names
RING-type E3 ubiquitin transferase RNF139
translocation in renal carcinoma on chromosome 8 protein
NP_780435.1
XP_017172276.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175226.4NP_780435.1  E3 ubiquitin-protein ligase RNF139

    See identical proteins and their annotated locations for NP_780435.1

    Status: VALIDATED

    Source sequence(s)
    AK029069, AK033506, CJ180442
    Consensus CDS
    CCDS27494.1
    UniProtKB/Swiss-Prot
    Q7TMV1
    UniProtKB/TrEMBL
    A0A0R4J0K8
    Related
    ENSMUSP00000046467.7, ENSMUST00000036904.7
    Conserved Domains (3) summary
    cd00162
    Location:547589
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam12678
    Location:544586
    zf-rbx1; RING-H2 zinc finger
    pfam13705
    Location:19516
    TRC8_N; TRC8 N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    58760975..58774239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316787.3XP_017172276.1  E3 ubiquitin-protein ligase RNF139 isoform X1

    Conserved Domains (2) summary
    cd16683
    Location:465506
    RING-H2_RNF139; RING finger, H2 subclass, found in RING finger protein 139 (RNF139) and similar proteins
    pfam13705
    Location:5436
    TRC8_N; TRC8 N-terminal domain
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