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Exoc6b exocyst complex component 6B [ Mus musculus (house mouse) ]

Gene ID: 75914, updated on 11-Apr-2024

Summary

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Official Symbol
Exoc6bprovided by MGI
Official Full Name
exocyst complex component 6Bprovided by MGI
Primary source
MGI:MGI:1923164
See related
Ensembl:ENSMUSG00000033769 AllianceGenome:MGI:1923164
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sec15b; Sec15l2; mKIAA0919; 4930569O18Rik; G430127E12Rik
Summary
Predicted to be involved in Golgi to plasma membrane transport and exocytosis. Predicted to be part of exocyst. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia with joint laxity type 3. Orthologous to human EXOC6B (exocyst complex component 6B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 7.4), cortex adult (RPKM 6.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Exoc6b in Genome Data Viewer
Location:
6 C3; 6 36.55 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (84595468..85046524, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (84618486..85070258, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930504D19 gene Neighboring gene STARR-seq mESC enhancer starr_16484 Neighboring gene STARR-seq mESC enhancer starr_16485 Neighboring gene cytochrome P450, family 26, subfamily b, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_16486 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_16489 Neighboring gene STARR-positive B cell enhancer mm9_chr6:84987737-84988037 Neighboring gene STARR-seq mESC enhancer starr_16492 Neighboring gene predicted gene, 57764 Neighboring gene STARR-seq mESC enhancer starr_16493 Neighboring gene nucleoplasmin 3, pseudogene 1 Neighboring gene predicted gene, 52864 Neighboring gene predicted gene 5878

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A catalogue of genes in mouse embryonal carcinoma F9 cells identified with expressed sequence tags. Nishiguchi S, et al. J Biochem, 1996 Apr. PMID 8743579
  2. Exorcising the exocyst complex. Heider MR, et al. Traffic, 2012 Jul. PMID 22420621, Free PMC Article
  3. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0919

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane fission NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle docking involved in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle tethering involved in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
exocyst complex component 6B
Names
SEC15-like 2
SEC15-like protein 2
exocyst complex component Sec15B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177077.2 → NP_796051.2  exocyst complex component 6B

    See identical proteins and their annotated locations for NP_796051.2

    Status: VALIDATED

    Source sequence(s)
    AC153373, AC153606, AC153994, AC155289, AC155331
    Consensus CDS
    CCDS51824.1
    UniProtKB/Swiss-Prot
    A6H5Z3, Q3UN15
    Related
    ENSMUSP00000125312.2, ENSMUST00000160197.6
    Conserved Domains (1) summary
    pfam04091
    Location:464 → 770
    Sec15; Exocyst complex subunit Sec15-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    84595468..85046524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506729.3 → XP_006506792.1  exocyst complex component 6B isoform X6

    Conserved Domains (1) summary
    pfam04091
    Location:352 → 658
    Sec15; Exocyst complex subunit Sec15-like

  2. XM_006506728.4 → XP_006506791.1  exocyst complex component 6B isoform X2

    Conserved Domains (1) summary
    pfam04091
    Location:464 → 769
    Sec15; Exocyst complex subunit Sec15-like

  3. XM_036152390.1 → XP_036008283.1  exocyst complex component 6B isoform X1

    Conserved Domains (2) summary
    pfam05483
    Location:2 → 266
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam04091
    Location:464 → 770
    Sec15; Exocyst complex subunit Sec15-like

  4. XM_036152391.1 → XP_036008284.1  exocyst complex component 6B isoform X3

    Conserved Domains (2) summary
    pfam05483
    Location:2 → 266
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam04091
    Location:464 → 769
    Sec15; Exocyst complex subunit Sec15-like

  5. XM_036152393.1 → XP_036008286.1  exocyst complex component 6B isoform X5

    Conserved Domains (1) summary
    pfam04091
    Location:352 → 658
    Sec15; Exocyst complex subunit Sec15-like

  6. XM_036152392.1 → XP_036008285.1  exocyst complex component 6B isoform X4

    Conserved Domains (2) summary
    pfam05483
    Location:2 → 266
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam04091
    Location:464 → 732
    Sec15; Exocyst complex subunit Sec15-like

  7. XM_017321822.3 → XP_017177311.1  exocyst complex component 6B isoform X7

    Conserved Domains (1) summary
    pfam04091
    Location:464 → 667
    Sec15; Exocyst complex subunit Sec15-like

  8. XM_011241500.3 → XP_011239802.1  exocyst complex component 6B isoform X8

    Conserved Domains (1) summary
    pfam04091
    Location:464 → 662
    Sec15; Exocyst complex subunit Sec15-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6H5Z3.1 GenPept UniProtKB/Swiss-Prot:A6H5Z3

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