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ZNF45 zinc finger protein 45 [ Homo sapiens (human) ]

Gene ID: 7596, updated on 11-Apr-2024

Summary

Official Symbol
ZNF45provided by HGNC
Official Full Name
zinc finger protein 45provided by HGNC
Primary source
HGNC:HGNC:13111
See related
Ensembl:ENSG00000124459 MIM:194554; AllianceGenome:HGNC:13111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX5; ZNF13
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 3.8), ovary (RPKM 3.8) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

Location:
19q13.31
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43912624..43935282, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46735535..46758192, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44416776..44439434, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 404 Neighboring gene uncharacterized LOC100505715 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14745 Neighboring gene ZNF45 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14747 Neighboring gene zinc finger protein 221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10732 Neighboring gene zinc finger protein 155 Neighboring gene ZNF230 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
The correlation between reading and mathematics ability at age twelve has a substantial genetic component.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
zinc finger protein 45
Names
BRC1744
zinc finger protein 13
zinc finger protein 45 (a Kruppel-associated box (KRAB) domain polypeptide)
zinc finger protein KOX5

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003425.4NP_003416.1  zinc finger protein 45

    See identical proteins and their annotated locations for NP_003416.1

    Status: VALIDATED

    Source sequence(s)
    AC006213
    Consensus CDS
    CCDS12632.1
    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
    Related
    ENSP00000269973.4, ENST00000269973.10
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    43912624..43935282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027227.3XP_016882716.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
    Related
    ENSP00000481895.1, ENST00000615985.4
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  2. XM_047439342.1XP_047295298.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  3. XM_017027226.3XP_016882715.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  4. XM_047439333.1XP_047295289.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  5. XM_047439325.1XP_047295281.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  6. XM_011527271.2XP_011525573.1  zinc finger protein 45 isoform X1

    See identical proteins and their annotated locations for XP_011525573.1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  7. XM_047439336.1XP_047295292.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  8. XM_047439332.1XP_047295288.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  9. XM_017027225.3XP_016882714.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  10. XM_047439328.1XP_047295284.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  11. XM_017027220.3XP_016882709.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  12. XM_047439343.1XP_047295299.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  13. XM_047439326.1XP_047295282.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  14. XM_047439338.1XP_047295294.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  15. XM_047439346.1XP_047295302.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  16. XM_047439329.1XP_047295285.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  17. XM_047439322.1XP_047295278.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  18. XM_047439345.1XP_047295301.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  19. XM_047439334.1XP_047295290.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  20. XM_047439337.1XP_047295293.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  21. XM_047439340.1XP_047295296.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  22. XM_047439330.1XP_047295286.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  23. XM_047439321.1XP_047295277.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  24. XM_047439348.1XP_047295304.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  25. XM_047439347.1XP_047295303.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  26. XM_047439323.1XP_047295279.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  27. XM_011527273.2XP_011525575.1  zinc finger protein 45 isoform X1

    See identical proteins and their annotated locations for XP_011525575.1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  28. XM_011527269.2XP_011525571.1  zinc finger protein 45 isoform X1

    See identical proteins and their annotated locations for XP_011525571.1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  29. XM_047439324.1XP_047295280.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  30. XM_047439320.1XP_047295276.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  31. XM_017027218.2XP_016882707.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  32. XM_011527267.2XP_011525569.1  zinc finger protein 45 isoform X1

    See identical proteins and their annotated locations for XP_011525569.1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  33. XM_017027222.2XP_016882711.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  34. XM_047439317.1XP_047295273.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  35. XM_017027217.2XP_016882706.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  36. XM_047439349.1XP_047295305.1  zinc finger protein 45 isoform X2

  37. XM_047439344.1XP_047295300.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  38. XM_047439339.1XP_047295295.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  39. XM_047439341.1XP_047295297.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  40. XM_047439319.1XP_047295275.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  41. XM_017027224.3XP_016882713.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  42. XM_047439331.1XP_047295287.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  43. XM_047439335.1XP_047295291.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  44. XM_047439327.1XP_047295283.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  45. XM_047439318.1XP_047295274.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46735535..46758192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321979.1XP_054177954.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  2. XM_054321973.1XP_054177948.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  3. XM_054321971.1XP_054177946.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  4. XM_054321969.1XP_054177944.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  5. XM_054321964.1XP_054177939.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  6. XM_054321968.1XP_054177943.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  7. XM_054321965.1XP_054177940.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  8. XM_054321966.1XP_054177941.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  9. XM_054321963.1XP_054177938.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  10. XM_054321981.1XP_054177956.1  zinc finger protein 45 isoform X2

  11. XM_054321980.1XP_054177955.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  12. XM_054321977.1XP_054177952.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  13. XM_054321978.1XP_054177953.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  14. XM_054321970.1XP_054177945.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  15. XM_054321974.1XP_054177949.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  16. XM_054321975.1XP_054177950.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  17. XM_054321976.1XP_054177951.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  18. XM_054321972.1XP_054177947.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9
  19. XM_054321967.1XP_054177942.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    P17016, P78472, Q02386, Q9P1U9