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Trappc8 trafficking protein particle complex 8 [ Mus musculus (house mouse) ]

Gene ID: 75964, updated on 5-Mar-2024

Summary

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Official Symbol
Trappc8provided by MGI
Official Full Name
trafficking protein particle complex 8provided by MGI
Primary source
MGI:MGI:2443008
See related
Ensembl:ENSMUSG00000033382 AllianceGenome:MGI:2443008
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trs85; mKIAA1012; 5033403J15Rik; D030074E01Rik
Summary
Predicted to be involved in several processes, including autophagy of peroxisome; endoplasmic reticulum to Golgi vesicle-mediated transport; and protein localization to phagophore assembly site. Predicted to be part of TRAPPIII protein complex. Predicted to be active in cytoplasmic vesicle and phagophore assembly site. Orthologous to human TRAPPC8 (trafficking protein particle complex subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 9.0), CNS E18 (RPKM 8.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Trappc8 in Genome Data Viewer
Location:
18 A2; 18 11.53 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (20950268..21033851, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (20817211..20896425, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35 pseudogene Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 Neighboring gene predicted gene, 31437 Neighboring gene STARR-seq mESC enhancer starr_43979 Neighboring gene STARR-seq mESC enhancer starr_43980 Neighboring gene STARR-seq mESC enhancer starr_43983 Neighboring gene STARR-seq mESC enhancer starr_43987 Neighboring gene STARR-seq mESC enhancer starr_43988 Neighboring gene STARR-positive B cell enhancer ABC_E11655 Neighboring gene STARR-seq mESC enhancer starr_43995 Neighboring gene STARR-seq mESC enhancer starr_43996 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:21115655-21115838 Neighboring gene ring finger protein 125 Neighboring gene STARR-seq mESC enhancer starr_43997 Neighboring gene STARR-positive B cell enhancer ABC_E3224 Neighboring gene STARR-seq mESC enhancer starr_43999 Neighboring gene ring finger protein 138

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ypt1 recruits the Atg1 kinase to the preautophagosomal structure. Wang J, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716696, Free PMC Article
  2. TRAPP Complexes in Secretion and Autophagy. Kim JJ, et al. Front Cell Dev Biol, 2016. PMID 27066478, Free PMC Article
  3. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in COPII vesicle coating NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle tethering NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of TRAPP complex ISO
Inferred from Sequence Orthology
more info
  
part_of TRAPPIII protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TRAPPIII protein complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
trafficking protein particle complex subunit 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361188.1 → NP_001348117.1  trafficking protein particle complex subunit 8 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AC122118, AC129078
    Conserved Domains (1) summary
    pfam12739
    Location:157 → 589
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

  2. NM_001379370.1 → NP_001366299.1  trafficking protein particle complex subunit 8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122118, AC129078
    Conserved Domains (1) summary
    pfam12739
    Location:160 → 603
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

  3. NM_029491.2 → NP_083767.2  trafficking protein particle complex subunit 8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK083747, AW912577
    Consensus CDS
    CCDS29087.1
    UniProtKB/TrEMBL
    E9PY51, Q8BJI6
    Related
    ENSMUSP00000095262.2, ENSMUST00000097658.2
    Conserved Domains (1) summary
    pfam12739
    Location:158 → 604
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

  4. NM_177038.3 → NP_796012.2  trafficking protein particle complex subunit 8 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK083747, AK173085, AW552459
    Consensus CDS
    CCDS50233.1
    UniProtKB/TrEMBL
    A0A286YCX6
    Related
    ENSMUSP00000153183.3, ENSMUST00000225661.3
    Conserved Domains (1) summary
    pfam12739
    Location:158 → 604
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    20950268..21033851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250631.2 → XP_030106491.1  trafficking protein particle complex subunit 8 isoform X12

    Conserved Domains (1) summary
    pfam12739
    Location:157 → 570
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

  2. XM_011247033.4 → XP_011245335.1  trafficking protein particle complex subunit 8 isoform X11

    Conserved Domains (1) summary
    pfam12739
    Location:157 → 577
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

  3. XM_030250630.2 → XP_030106490.1  trafficking protein particle complex subunit 8 isoform X10

    Conserved Domains (1) summary
    pfam12739
    Location:157 → 585
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

  4. XM_011247032.4 → XP_011245334.1  trafficking protein particle complex subunit 8 isoform X8

    Conserved Domains (1) summary
    pfam12739
    Location:157 → 592
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

  5. XM_030250629.2 → XP_030106489.1  trafficking protein particle complex subunit 8 isoform X9

    Conserved Domains (1) summary
    pfam12739
    Location:157 → 589
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

  6. XM_011247031.4 → XP_011245333.1  trafficking protein particle complex subunit 8 isoform X7

    Conserved Domains (1) summary
    pfam12739
    Location:157 → 596
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

  7. XM_030250628.2 → XP_030106488.1  trafficking protein particle complex subunit 8 isoform X5

    Conserved Domains (1) summary
    pfam12739
    Location:157 → 603
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

  8. XM_011247028.4 → XP_011245330.1  trafficking protein particle complex subunit 8 isoform X2

    Conserved Domains (1) summary
    pfam12739
    Location:157 → 610
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

  9. XM_011247029.4 → XP_011245331.1  trafficking protein particle complex subunit 8 isoform X4

    Conserved Domains (1) summary
    pfam12739
    Location:157 → 604
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

  10. XM_017318012.3 → XP_017173501.1  trafficking protein particle complex subunit 8 isoform X3

    Conserved Domains (1) summary
    pfam12739
    Location:157 → 610
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

  11. XM_011247030.4 → XP_011245332.1  trafficking protein particle complex subunit 8 isoform X6

    Conserved Domains (1) summary
    pfam12739
    Location:157 → 611
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

  12. XM_017318011.3 → XP_017173500.1  trafficking protein particle complex subunit 8 isoform X1

    Conserved Domains (1) summary
    pfam12739
    Location:157 → 611
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

RNA

  1. XR_001782396.3 RNA Sequence

  2. XR_001782397.3 RNA Sequence

  3. XR_004939888.1 RNA Sequence

  4. XR_001782399.3 RNA Sequence

  5. XR_001782398.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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