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Rnf183 ring finger protein 183 [ Mus musculus (house mouse) ]

Gene ID: 76072, updated on 21-Apr-2024

Summary

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Official Symbol
Rnf183provided by MGI
Official Full Name
ring finger protein 183provided by MGI
Primary source
MGI:MGI:1923322
See related
Ensembl:ENSMUSG00000063851 AllianceGenome:MGI:1923322
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5830442J12Rik
Summary
Enables ubiquitin protein ligase activity. Involved in protein autoubiquitination. Located in cis-Golgi network membrane; endoplasmic reticulum membrane; and lysosomal membrane. Is expressed in brain; genitourinary system; gut; and thymus. Orthologous to human RNF183 (ring finger protein 183). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 38.5) and thymus adult (RPKM 3.1) See more
Orthologs
human all
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Genomic context

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Location:
4 B3; 4 33.13 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62345777..62353487, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62427540..62435250, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cell division cycle 26 Neighboring gene STARR-positive B cell enhancer mm9_chr4:62069546-62069847 Neighboring gene pre-mRNA processing factor 4 Neighboring gene predicted gene, 30589 Neighboring gene WD repeat domain 31 Neighboring gene B-box and SPRY domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5. Maeoka Y, et al. Biochem Biophys Res Commun, 2019 Jun 25. PMID 31053298
  2. NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells. Maeoka Y, et al. J Biol Chem, 2019 Jan 4. PMID 30413537, Free PMC Article
  3. E3 Ubiquitin ligase RNF183 Is a Novel Regulator in Inflammatory Bowel Disease. Yu Q, et al. J Crohns Colitis, 2016 Jun. PMID 26818663
  4. Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183. Wu Y, et al. PLoS One, 2018. PMID 29300766, Free PMC Article
  5. Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit. Okamoto T, et al. Biochem Biophys Res Commun, 2020 Jan 22. PMID 31732153

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results indicated that RNF183 is predominantly expressed in the renal medullary collecting ducts, and that decreased renal medullary tonicity by furosemide treatment decreases RNF183 expression by NFAT5 downregulation
    Title: Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5.
  2. These results indicate that (i) RNF183 is predominantly expressed in the normal renal medulla, (ii) NFAT5 stimulates transcriptional activation of Rnf183 by binding to its cognate binding motif in the Rnf183 promoter, and (iii) RNF183 protects renal medullary cells from hypertonicity-induced apoptosis.
    Title: NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells.
  3. RNF183, which is negatively regulated by miR-7, is a novel regulator promoting intestinal inflammation by increasing the ubiquitination and degradation of IkappaBalpha, thereby inducing NF-kappaB activation. The interaction between RNF183-mediated ubiquitination and miRNA may be an important novel epigenetic mechanism in the pathogenesis of inflammatory bowel disease.
    Title: E3 Ubiquitin ligase RNF183 Is a Novel Regulator in Inflammatory Bowel Disease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cis-Golgi network membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF183
Names
probable E3 ubiquitin-protein ligase RNF183
NP_001366552.1
NP_001366553.1
NP_001366554.1
NP_705724.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379623.1 → NP_001366552.1  E3 ubiquitin-protein ligase RNF183

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AL732594
    UniProtKB/Swiss-Prot
    B7ZCH3, Q5NBV8, Q8QZS5
    Related
    ENSMUSP00000103079.2, ENSMUST00000107455.8
    Conserved Domains (1) summary
    cd16556
    Location:12 → 63
    RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins

  2. NM_001379624.1 → NP_001366553.1  E3 ubiquitin-protein ligase RNF183

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AL732594
    UniProtKB/Swiss-Prot
    B7ZCH3, Q5NBV8, Q8QZS5
    Related
    ENSMUSP00000103078.2, ENSMUST00000107454.2
    Conserved Domains (1) summary
    cd16556
    Location:12 → 63
    RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins

  3. NM_001379625.1 → NP_001366554.1  E3 ubiquitin-protein ligase RNF183

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AL732594
    UniProtKB/Swiss-Prot
    B7ZCH3, Q5NBV8, Q8QZS5
    Related
    ENSMUSP00000078389.7, ENSMUST00000079420.7
    Conserved Domains (1) summary
    cd16556
    Location:12 → 63
    RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins

  4. NM_153504.4 → NP_705724.1  E3 ubiquitin-protein ligase RNF183

    See identical proteins and their annotated locations for NP_705724.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AL732594
    Consensus CDS
    CCDS38775.1
    UniProtKB/Swiss-Prot
    B7ZCH3, Q5NBV8, Q8QZS5
    Conserved Domains (1) summary
    cd16556
    Location:12 → 63
    RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    62345777..62353487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8QZS5.1 GenPept UniProtKB/Swiss-Prot:Q8QZS5

Gene LinkOut

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