U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Arhgap15 Rho GTPase activating protein 15 [ Mus musculus (house mouse) ]

Gene ID: 76117, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Arhgap15provided by MGI
Official Full Name
Rho GTPase activating protein 15provided by MGI
Primary source
MGI:MGI:1923367
See related
Ensembl:ENSMUSG00000049744 AllianceGenome:MGI:1923367
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5830480G12Rik
Summary
The protein encoded by this gene is a RAC GTPase-activating protein that is regulated through its PH domain and by recruitment to the membrane. The protein accelerates hydrolysis of guanosine triphosphate to guanosine diphosphate to repress Rac activity. Knock-out of Arhgap15 function demonstrates that this gene is required to regulate multiple functions in macrophages and neutrophils. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Expression
Broad expression in thymus adult (RPKM 1.0), cortex adult (RPKM 0.9) and 21 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2 B; 2 26.13 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (43638786..44285965)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (43748798..44395953)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11131 Neighboring gene STARR-positive B cell enhancer mm9_chr2:43441000-43441301 Neighboring gene STARR-positive B cell enhancer mm9_chr2:43478445-43478746 Neighboring gene STARR-seq mESC enhancer starr_04386 Neighboring gene kynureninase Neighboring gene STARR-positive B cell enhancer ABC_E4451 Neighboring gene STARR-seq mESC enhancer starr_04387 Neighboring gene STARR-positive B cell enhancer ABC_E9513 Neighboring gene STARR-seq mESC enhancer starr_04388 Neighboring gene STARR-positive B cell enhancer ABC_E636 Neighboring gene predicted gene, 30374 Neighboring gene predicted gene, 39804 Neighboring gene Rho GTPase activating protein 15, opposite strand Neighboring gene STARR-seq mESC enhancer starr_04390 Neighboring gene STARR-seq mESC enhancer starr_04391 Neighboring gene STARR-seq mESC enhancer starr_04393 Neighboring gene STARR-positive B cell enhancer mm9_chr2:44200426-44200727 Neighboring gene predicted gene, 52508 Neighboring gene STARR-seq mESC enhancer starr_04394 Neighboring gene predicted gene, 39805 Neighboring gene predicted gene, 39806

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Rac signal adaptation controls neutrophil mobilization from the bone marrow. Campa CC, et al. Sci Signal, 2016 Dec 20. PMID 27999173
  2. The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions. Costa C, et al. Blood, 2011 Jul 28. PMID 21551229
  3. Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics. Zamboni V, et al. Sci Rep, 2018 May 8. PMID 29740022, Free PMC Article
  4. Loss of ARHGAP15 affects the directional control of migrating interneurons in the embryonic cortex and increases susceptibility to epilepsy. Liaci C, et al. Front Cell Dev Biol, 2022. PMID 36568982, Free PMC Article
  5. Extensive variation between inbred mouse strains due to endogenous L1 retrotransposition. Akagi K, et al. Genome Res, 2008 Jun. PMID 18381897, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ArhGAP15 role in the modulation of Rac1/Rac3 activity in the hippocampal inhibitory neurons.
    Title: Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits.
  2. these results demonstrate the relevance of ArhGAP15 in the selective regulation of multiple neutrophil functions
    Title: The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions.
  3. Arhgap15 is associated with acute lung injury
    Title: Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
rho GTPase-activating protein 15
Names
rho-type GTPase-activating protein 15

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301831.1 → NP_001288760.1  rho GTPase-activating protein 15 isoform 3

    See identical proteins and their annotated locations for NP_001288760.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK036520, AK040796, AL844535
    Consensus CDS
    CCDS79793.1
    UniProtKB/TrEMBL
    A0A2X0SSE2, B1AW40
    Related
    ENSMUSP00000108443.2, ENSMUST00000112824.8
    Conserved Domains (3) summary
    cd13233
    Location:89 → 198
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:88 → 196
    PH; PH domain
    cl02570
    Location:285 → 423
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

  2. NM_001301832.1 → NP_001288761.1  rho GTPase-activating protein 15 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' end of the transcript compared to variant 1. This causes translation initiation at a downstream AUG and results in an isoform (4) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK036520, AK040796, BF453909
    Conserved Domains (2) summary
    cd04403
    Location:150 → 336
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cl17171
    Location:1 → 63
    PH-like; Pleckstrin homology-like domain

  3. NM_001364029.1 → NP_001350958.1  rho GTPase-activating protein 15 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL732320, AL844535, AL845160, AL928611, AL935152
    UniProtKB/TrEMBL
    A0A2X0SSE2
    Conserved Domains (2) summary
    cd04403
    Location:240 → 426
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:44 → 153
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

  4. NM_153820.3 → NP_722542.2  rho GTPase-activating protein 15 isoform 1

    See identical proteins and their annotated locations for NP_722542.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI840874, AK036520, AK040796, BC034881
    Consensus CDS
    CCDS16019.1
    UniProtKB/Swiss-Prot
    Q3T9M8, Q3TCU0, Q811M1, Q8C0I5, Q8JZY0
    UniProtKB/TrEMBL
    A0A2X0SSE2
    Related
    ENSMUSP00000056461.7, ENSMUST00000055776.8
    Conserved Domains (3) summary
    cd04403
    Location:285 → 471
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:89 → 198
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:88 → 196
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    43638786..44285965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162663.1 → XP_036018556.1  rho GTPase-activating protein 15 isoform X3

    UniProtKB/TrEMBL
    A0A2X0SSE2
    Conserved Domains (2) summary
    cd13233
    Location:89 → 198
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    cl02570
    Location:285 → 387
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  2. XM_006498402.5 → XP_006498465.1  rho GTPase-activating protein 15 isoform X4

    Conserved Domains (2) summary
    cd13233
    Location:89 → 198
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    cl02570
    Location:285 → 404
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  3. XM_006498398.5 → XP_006498461.1  rho GTPase-activating protein 15 isoform X1

    UniProtKB/TrEMBL
    A0A2X0SSE2
    Conserved Domains (2) summary
    cd04403
    Location:262 → 448
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:66 → 175
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

  4. XM_006498399.5 → XP_006498462.1  rho GTPase-activating protein 15 isoform X2

    See identical proteins and their annotated locations for XP_006498462.1

    UniProtKB/TrEMBL
    A0A2X0SSE2
    Conserved Domains (2) summary
    cd04403
    Location:252 → 438
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:56 → 165
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

  5. XM_006498403.3 → XP_006498466.1  rho GTPase-activating protein 15 isoform X5

    See identical proteins and their annotated locations for XP_006498466.1

    UniProtKB/TrEMBL
    B2X2D4
    Conserved Domains (1) summary
    cd04403
    Location:91 → 247
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001025377.1: Suppressed sequence

    Description
    NM_001025377.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q811M1.1 GenPept UniProtKB/Swiss-Prot:Q811M1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous