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ZNF69 zinc finger protein 69 [ Homo sapiens (human) ]

Gene ID: 7620, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF69provided by HGNC
Official Full Name
zinc finger protein 69provided by HGNC
Primary source
HGNC:HGNC:13138
See related
Ensembl:ENSG00000198429 MIM:194543; AllianceGenome:HGNC:13138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cos5; hZNF3
Summary
Enables identical protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 1.9), colon (RPKM 1.9) and 25 other tissues See more
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Genomic context

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Location:
19p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11887782..11980222)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12015990..12108415)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11998597..12025371)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 439 Neighboring gene Sharpr-MPRA regulatory region 10901 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14036 Neighboring gene vomeronasal 2 receptor 14 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14037 Neighboring gene zinc finger protein 440-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12033828-12034618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12034619-12035408 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12035565-12036137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10135 Neighboring gene vomeronasal 2 receptor 15 pseudogene Neighboring gene zinc finger protein 700 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:12060504-12060733 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12074983-12075936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10136 Neighboring gene vomeronasal 2 receptor 21 pseudogene Neighboring gene zinc finger protein 763 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12098284-12099226 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12099227-12100168 Neighboring gene ZNF433 and ZNF878 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14042 Neighboring gene RNA, 5S ribosomal pseudogene 464 Neighboring gene zinc finger protein 433 Neighboring gene RNA, 5S ribosomal pseudogene 465

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). Aubry M, et al. Genomics, 1992 Jul. PMID 1639391
  2. Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer. Yeow ZY, et al. Nature, 2020 Sep. PMID 32908313, Free PMC Article
  3. Systematic identification of pathological lamin A interactors. Dittmer TA, et al. Mol Biol Cell, 2014 May. PMID 24623722, Free PMC Article
  4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC59928

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 69
Names
ZNF3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321163.2 → NP_001308092.1  zinc finger protein 69 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008770, AW132096, BG393583, BG429615
    UniProtKB/TrEMBL
    C9JR48
    Conserved Domains (2) summary
    smart00349
    Location:24 → 64
    KRAB; krueppel associated box
    pfam01352
    Location:24 → 63
    KRAB; KRAB box

  2. NM_001364730.1 → NP_001351659.1  zinc finger protein 69 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008770, BG393583, DA647393
    Consensus CDS
    CCDS92521.1
    UniProtKB/Swiss-Prot
    Q86VA7, Q9UC07
    Related
    ENSP00000402985.2, ENST00000429654.7
    Conserved Domains (3) summary
    COG5048
    Location:219 → 537
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:362 → 382
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:23 → 64
    KRAB; KRAB box

  3. NM_001364731.1 → NP_001351660.1  zinc finger protein 69 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC008770, DA633065
    Conserved Domains (3) summary
    COG5048
    Location:205 → 523
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:348 → 368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:22 → 50
    KRAB; KRAB box

  4. NM_021915.4 → NP_068734.1  zinc finger protein 69 isoform 2

    See identical proteins and their annotated locations for NP_068734.1

    Status: VALIDATED

    Source sequence(s)
    AC008770, AW132096, BC051309, BG393583
    Consensus CDS
    CCDS32914.1
    UniProtKB/TrEMBL
    C9JR48
    Related
    ENSP00000345333.5, ENST00000340180.5
    Conserved Domains (1) summary
    pfam01352
    Location:22 → 50
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    11887782..11980222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027231.2 → XP_016882720.1  zinc finger protein 69 isoform X4

    UniProtKB/TrEMBL
    C9JR48
    Conserved Domains (2) summary
    smart00349
    Location:27 → 67
    KRAB; krueppel associated box
    pfam01352
    Location:27 → 66
    KRAB; KRAB box

  2. XM_006722874.4 → XP_006722937.1  zinc finger protein 69 isoform X3

    See identical proteins and their annotated locations for XP_006722937.1

    UniProtKB/TrEMBL
    C9JR48
    Conserved Domains (2) summary
    smart00349
    Location:27 → 67
    KRAB; krueppel associated box
    pfam01352
    Location:27 → 66
    KRAB; KRAB box

  3. XM_006722873.5 → XP_006722936.1  zinc finger protein 69 isoform X1

    Conserved Domains (5) summary
    smart00349
    Location:27 → 67
    KRAB; krueppel associated box
    COG5048
    Location:222 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365 → 385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:27 → 66
    KRAB; KRAB box
    pfam13465
    Location:405 → 430
    zf-H2C2_2; Zinc-finger double domain

  4. XM_047439351.1 → XP_047295307.1  zinc finger protein 69 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    12015990..12108415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321985.1 → XP_054177960.1  zinc finger protein 69 isoform X4

  2. XM_054321984.1 → XP_054177959.1  zinc finger protein 69 isoform X3

  3. XM_054321983.1 → XP_054177958.1  zinc finger protein 69 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UC07.2 GenPept UniProtKB/Swiss-Prot:Q9UC07

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